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    RGS4 regulator of G protein signaling 4 [ Homo sapiens (human) ]

    Gene ID: 5999, updated on 17-Sep-2022

    Summary

    Official Symbol
    RGS4provided by HGNC
    Official Full Name
    regulator of G protein signaling 4provided by HGNC
    Primary source
    HGNC:HGNC:10000
    See related
    Ensembl:ENSG00000117152 MIM:602516; AllianceGenome:HGNC:10000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGP4; SCZD9
    Summary
    Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RGS4 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (163068871..163076802)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (162413422..162421357)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163038661..163046592)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like Neighboring gene uncharacterized LOC107985223 Neighboring gene uncharacterized LOC124904446 Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene regulator of G protein signaling 5 Neighboring gene RGS5 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC2124, MGC60244, DKFZp761F1924

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal root ganglion development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glycine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 4
    Names
    schizophrenia disorder 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023312.1 RefSeqGene

      Range
      5756..13197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001102445.3NP_001095915.1  regulator of G-protein signaling 4 isoform 1

      See identical proteins and their annotated locations for NP_001095915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL583850, DQ346664
      Consensus CDS
      CCDS44270.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000397181.2, ENST00000421743.6
      Conserved Domains (1) summary
      cd08714
      Location:160273
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
    2. NM_001113380.1NP_001106851.1  regulator of G-protein signaling 4 isoform 3

      See identical proteins and their annotated locations for NP_001106851.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL583850, EF054877
      Consensus CDS
      CCDS44272.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000356882.3, ENST00000367906.7
      Conserved Domains (1) summary
      cd08714
      Location:45158
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
    3. NM_001113381.1NP_001106852.1  regulator of G-protein signaling 4 isoform 4

      See identical proteins and their annotated locations for NP_001106852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK093959, AL583850, DA660695
      Consensus CDS
      CCDS44271.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000356884.4, ENST00000367908.8
    4. NM_005613.6NP_005604.1  regulator of G-protein signaling 4 isoform 2

      See identical proteins and their annotated locations for NP_005604.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL583850, DQ346663
      Consensus CDS
      CCDS1243.1
      UniProtKB/Swiss-Prot
      B1APZ3, P49798
      UniProtKB/TrEMBL
      A0A024R909
      Related
      ENSP00000356885.6, ENST00000367909.11
      Conserved Domains (1) summary
      cd08714
      Location:63176
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      163068871..163076802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      162413422..162421357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)