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    RGS3 regulator of G protein signaling 3 [ Homo sapiens (human) ]

    Gene ID: 5998, updated on 17-Sep-2022

    Summary

    Official Symbol
    RGS3provided by HGNC
    Official Full Name
    regulator of G protein signaling 3provided by HGNC
    Primary source
    HGNC:HGNC:9999
    See related
    Ensembl:ENSG00000138835 MIM:602189; AllianceGenome:HGNC:9999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2PA; RGP3
    Summary
    This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in heart (RPKM 8.0), fat (RPKM 4.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RGS3 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113444730..113597738)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125643547..125796339)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116207010..116360018)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aminolevulinate dehydratase Neighboring gene chromosome 9 open reading frame 43 Neighboring gene DNA polymerase epsilon 3, accessory subunit Neighboring gene Sharpr-MPRA regulatory region 4137 Neighboring gene uncharacterized LOC105376222 Neighboring gene Sharpr-MPRA regulatory region 10953 Neighboring gene uncharacterized LOC105376223

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20370, FLJ31516, FLJ90496

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 3
    Names
    regulator of G-protein signalling 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029512.1 RefSeqGene

      Range
      23997..158008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276260.2NP_001263189.1  regulator of G-protein signaling 3 isoform 2

      See identical proteins and their annotated locations for NP_001263189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).
      Source sequence(s)
      AK123387, AK226153, BM690084, U27655
      Consensus CDS
      CCDS6798.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831, B3KVT7
      Related
      ENSP00000420356.1, ENST00000462143.5
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    2. NM_001276261.2NP_001263190.1  regulator of G-protein signaling 3 isoform 7

      See identical proteins and their annotated locations for NP_001263190.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the 3' coding region, compared to variant 6. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AK096840, AK226153, BM690084
      Consensus CDS
      CCDS65111.1
      UniProtKB/Swiss-Prot
      P49796
      Related
      ENSP00000378141.3, ENST00000394646.7
      Conserved Domains (2) summary
      cd08713
      Location:467580
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cd00992
      Location:1791
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. NM_001276262.2NP_001263191.1  regulator of G-protein signaling 3 isoform 4

      See identical proteins and their annotated locations for NP_001263191.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (4, also known as RGS3S in PubMedID:11330340) is significantly shorter at the N-terminus, compared to isoform 6. Both variants 4 and 9 encode isoform 4.
      Source sequence(s)
      AL162727, BC019039, BE256545
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      H7BXY1
      Conserved Domains (1) summary
      cd08713
      Location:44157
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    4. NM_001282922.2NP_001269851.1  regulator of G-protein signaling 3 isoform 2

      See identical proteins and their annotated locations for NP_001269851.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).
      Source sequence(s)
      BC019039, DA875652, U27655
      Consensus CDS
      CCDS6798.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Related
      ENSP00000363249.3, ENST00000374134.7
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    5. NM_001282923.2NP_001269852.1  regulator of G-protein signaling 3 isoform 8 precursor

      See identical proteins and their annotated locations for NP_001269852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate 5' structure and thus differs in the 5' UTR and 5' coding region compared to variant 6. These differences cause translation initiation at an alternate AUG and result in an isoform (8) with a shorter and distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AF463495, AK074977, AK125059, AK226153, BM690084, DA680346
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      B3KWG8
      Related
      ENST00000478599.5
      Conserved Domains (6) summary
      cd08685
      Location:44148
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:9641077
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      COG0265
      Location:209264
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:190262
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16228
      Location:533699
      DUF4887; Domain of unknown function (DUF4887)
      cl23807
      Location:588661
      WWbp; WW-domain ligand protein
    6. NM_001322214.3NP_001309143.1  regulator of G-protein signaling 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL162727, AL359455
      Conserved Domains (1) summary
      cd00992
      Location:1791
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    7. NM_001322215.2NP_001309144.1  regulator of G-protein signaling 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL162727
      Conserved Domains (1) summary
      cd08713
      Location:413526
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    8. NM_001351526.2NP_001338455.1  regulator of G-protein signaling 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks several 5' exons but includes several alternate exons in the 5' region, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).
      Source sequence(s)
      AF463495, AL162727, AY585192, BE385269, BP257809, BQ953216, DA575364
      Consensus CDS
      CCDS6798.1
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    9. NM_001394167.1NP_001381096.1  regulator of G-protein signaling 3 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL137066, AL162727, AL359455
      Related
      ENSP00000511882.1, ENST00000695401.1
      Conserved Domains (4) summary
      cd08685
      Location:27146
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:9621075
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      PHA03247
      Location:578740
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:188260
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    10. NM_017790.6NP_060260.3  regulator of G-protein signaling 3 isoform 3

      See identical proteins and their annotated locations for NP_060260.3

      Status: REVIEWED

      Source sequence(s)
      AL137066, AL162727, AL359455
      Consensus CDS
      CCDS35113.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      B3KWG8, Q53GP3
      Related
      ENSP00000312844.6, ENST00000317613.10
      Conserved Domains (3) summary
      cd08685
      Location:27146
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      COG0265
      Location:207262
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:188260
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    11. NM_130795.4NP_570613.2  regulator of G-protein signaling 3 isoform 1

      See identical proteins and their annotated locations for NP_570613.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 6. The encoded isoform (1, also known as PDZ-RGS3) has a shorter and distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AF463495, AK226153, BC042555, BM690084
      Consensus CDS
      CCDS6797.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R841
      Related
      ENSP00000340284.5, ENST00000343817.9
      Conserved Domains (4) summary
      cd08713
      Location:793906
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      COG0265
      Location:3893
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:1791
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16228
      Location:362528
      DUF4887; Domain of unknown function (DUF4887)
    12. NM_134427.3NP_602299.1  regulator of G-protein signaling 3 isoform 4

      See identical proteins and their annotated locations for NP_602299.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (4, also known as RGS3S in PubMed ID:11330340) is significantly shorter at the N-terminus, compared to isoform 6. Both variants 4 and 9 encode isoform 4.
      Source sequence(s)
      BC019039, BE298009, BP257809
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      H7BXY1
      Related
      ENSP00000343359.5, ENST00000342620.9
      Conserved Domains (1) summary
      cd08713
      Location:44157
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    13. NM_144488.8NP_652759.4  regulator of G-protein signaling 3 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL137066, AL162727, AL359455
      Consensus CDS
      CCDS43869.1
      Related
      ENSP00000363255.2, ENST00000374140.6
      Conserved Domains (4) summary
      cd08685
      Location:35154
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:9701083
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      PHA03247
      Location:586748
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:196268
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    14. NM_144489.4NP_652760.3  regulator of G-protein signaling 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL162727
      Consensus CDS
      CCDS35114.1
      UniProtKB/TrEMBL
      A0A087WUY2
      Related
      ENSP00000479017.1, ENST00000620489.1
      Conserved Domains (1) summary
      cd08713
      Location:68181
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      113444730..113597738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      125643547..125796339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)