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    RGS3 regulator of G protein signaling 3 [ Homo sapiens (human) ]

    Gene ID: 5998, updated on 2-Oct-2018

    Summary

    Official Symbol
    RGS3provided by HGNC
    Official Full Name
    regulator of G protein signaling 3provided by HGNC
    Primary source
    HGNC:HGNC:9999
    See related
    Ensembl:ENSG00000138835 MIM:602189; Vega:OTTHUMG00000021048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2PA; RGP3
    Summary
    This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in heart (RPKM 8.0), fat (RPKM 4.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See RGS3 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (113444032..113597743)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116207009..116360023)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aminolevulinate dehydratase Neighboring gene chromosome 9 open reading frame 43 Neighboring gene DNA polymerase epsilon 3, accessory subunit Neighboring gene uncharacterized LOC105376222 Neighboring gene uncharacterized LOC105376223

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
      Ephrin B reverse signaling, organism-specific biosystem
      Ephrin B reverse signaling
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20370, FLJ31516, FLJ90496

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    inactivation of MAPK activity TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 3
    Names
    regulator of G-protein signalling 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029512.1 RefSeqGene

      Range
      4999..158013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276260.1NP_001263189.1  regulator of G-protein signaling 3 isoform 2

      See identical proteins and their annotated locations for NP_001263189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).
      Source sequence(s)
      AK123387, AK226153, BM690084, DA396065, U27655
      Consensus CDS
      CCDS6798.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831, B3KVT7
      Related
      ENSP00000420356.1, OTTHUMP00000215342, ENST00000462143.5, OTTHUMT00000355385
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    2. NM_001276261.1NP_001263190.1  regulator of G-protein signaling 3 isoform 7

      See identical proteins and their annotated locations for NP_001263190.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the 3' coding region, compared to variant 6. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AF463495, AK096840, AK226153, BM690084
      Consensus CDS
      CCDS65111.1
      UniProtKB/Swiss-Prot
      P49796
      Related
      ENSP00000378141.3, ENST00000394646.7
      Conserved Domains (2) summary
      cd08713
      Location:467580
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cd00992
      Location:1791
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. NM_001276262.1NP_001263191.1  regulator of G-protein signaling 3 isoform 4

      See identical proteins and their annotated locations for NP_001263191.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (4, also known as RGS3S in PubMedID:11330340) is significantly shorter at the N-terminus, compared to isoform 6. Both variants 4 and 9 encode isoform 4.
      Source sequence(s)
      AL162727, BC019039, BE256545, BM690084
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      H7BXY1
      Related
      ENSP00000479017.1, OTTHUMP00000275380, ENST00000620489.1, OTTHUMT00000475896
      Conserved Domains (1) summary
      cd08713
      Location:44157
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    4. NM_001282922.1NP_001269851.1  regulator of G-protein signaling 3 isoform 2

      See identical proteins and their annotated locations for NP_001269851.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).
      Source sequence(s)
      BC019039, BM690084, DA875652, U27655
      Consensus CDS
      CCDS6798.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Related
      ENSP00000363249.3, OTTHUMP00000022815, ENST00000374134.7, OTTHUMT00000055567
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    5. NM_001282923.1NP_001269852.1  regulator of G-protein signaling 3 isoform 8 precursor

      See identical proteins and their annotated locations for NP_001269852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate 5' structure and thus differs in the 5' UTR and 5' coding region compared to variant 6. These differences cause translation initiation at an alternate AUG and result in an isoform (8) with a shorter and distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AF463495, AK074977, AK125059, AK226153, BM690084, DA680346
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      B3KWG8
      Conserved Domains (6) summary
      cd08685
      Location:44148
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:9641077
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      COG0265
      Location:209264
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:190262
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16228
      Location:533699
      DUF4887; Domain of unknown function (DUF4887)
      cl23807
      Location:588661
      WWbp; WW-domain ligand protein
    6. NM_001322214.1NP_001309143.1  regulator of G-protein signaling 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL359455
      Conserved Domains (1) summary
      cd00992
      Location:1791
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    7. NM_001322215.1NP_001309144.1  regulator of G-protein signaling 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL162727
      Conserved Domains (1) summary
      cd08713
      Location:413526
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    8. NM_001351526.1NP_001338455.1  regulator of G-protein signaling 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks several 5' exons but includes several alternate exons in the 5' region, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 6. Variants 2, 7 and 13 encode the same isoform (2).
      Source sequence(s)
      AF463495, AL162727, AY585192, BE385269, BM690084, BP257809, BQ953216, DA575364
      Consensus CDS
      CCDS6798.1
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    9. NM_017790.4NP_060260.3  regulator of G-protein signaling 3 isoform 3

      See identical proteins and their annotated locations for NP_060260.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 5' and 3' exons but includes alternate 5' and 3' exons, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 6. The encoded isoform (3) is shorter and has distinct N- and C-termini, compared to isoform 6.
      Source sequence(s)
      AK074977, AK125059, AK222888, DA680346
      Consensus CDS
      CCDS35113.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      B3KWG8, Q53GP3
      Related
      ENSP00000312844.6, OTTHUMP00000022813, ENST00000317613.10, OTTHUMT00000055562
      Conserved Domains (3) summary
      cd08685
      Location:27146
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      COG0265
      Location:207262
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:188260
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    10. NM_130795.3NP_570613.2  regulator of G-protein signaling 3 isoform 1

      See identical proteins and their annotated locations for NP_570613.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 6. The encoded isoform (1, also known as PDZ-RGS3) has a shorter and distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AF463495, AK226153, BC042555, BM690084
      Consensus CDS
      CCDS6797.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R841
      Related
      ENSP00000340284.5, OTTHUMP00000022814, ENST00000343817.9, OTTHUMT00000055566
      Conserved Domains (4) summary
      cd08713
      Location:793906
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      COG0265
      Location:3893
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:1791
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16228
      Location:362528
      DUF4887; Domain of unknown function (DUF4887)
    11. NM_134427.2NP_602299.1  regulator of G-protein signaling 3 isoform 4

      See identical proteins and their annotated locations for NP_602299.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 6. The encoded isoform (4, also known as RGS3S in PubMed ID:11330340) is significantly shorter at the N-terminus, compared to isoform 6. Both variants 4 and 9 encode isoform 4.
      Source sequence(s)
      BC019039, BE298009, BM690084, BP257809
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      H7BXY1
      Related
      ENSP00000343359.5, ENST00000342620.9
      Conserved Domains (1) summary
      cd08713
      Location:44157
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    12. NM_144488.5NP_652759.3  regulator of G-protein signaling 3 isoform 6

      See identical proteins and their annotated locations for NP_652759.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (6, also known as C2PA-RGS3).
      Source sequence(s)
      AK128127, AK226153, BM690084, DB031297
      Consensus CDS
      CCDS43869.1
      UniProtKB/Swiss-Prot
      P49796
      Related
      ENSP00000363255.2, OTTHUMP00000022812, ENST00000374140.6, OTTHUMT00000055561
      Conserved Domains (4) summary
      cd08685
      Location:139258
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:10741187
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cd00992
      Location:300372
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl26464
      Location:690852
      Atrophin-1; Atrophin-1 family
    13. NM_144489.3NP_652760.2  regulator of G-protein signaling 3 isoform 5

      See identical proteins and their annotated locations for NP_652760.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks several 5' exons but includes an alternate 5' exon, and it thus differs in the 5' UTR, lacks a large portion of the 5' coding region, and uses an alternate start codon, compared to variant 6. The encoded isoform (5, also known as RGS3S in PubMed ID:12036301) has a significantly shorter and distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AF490838, AL162727, BC019039, BM690084
      Consensus CDS
      CCDS35114.1
      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R833
      Related
      ENSP00000482612.1, ENST00000613049.4
      Conserved Domains (1) summary
      cd08713
      Location:187300
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      113444032..113597743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447636.1XP_024303404.1  regulator of G-protein signaling 3 isoform X1

      Conserved Domains (4) summary
      cd08685
      Location:139258
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:10741187
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cd00992
      Location:300372
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl26464
      Location:690852
      Atrophin-1; Atrophin-1 family
    2. XM_006717219.2XP_006717282.1  regulator of G-protein signaling 3 isoform X3

      UniProtKB/Swiss-Prot
      P49796
      Conserved Domains (6) summary
      cd08685
      Location:35154
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:9701083
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      COG0265
      Location:215270
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:196268
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16228
      Location:539705
      DUF4887; Domain of unknown function (DUF4887)
      cl23807
      Location:594667
      WWbp; WW-domain ligand protein
    3. XM_017015003.1XP_016870492.1  regulator of G-protein signaling 3 isoform X2

    4. XM_011518893.1XP_011517195.1  regulator of G-protein signaling 3 isoform X5

      Conserved Domains (3) summary
      cd08685
      Location:139258
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      COG0265
      Location:319374
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:300372
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    5. XM_006717220.1XP_006717283.1  regulator of G-protein signaling 3 isoform X4

      See identical proteins and their annotated locations for XP_006717283.1

      Conserved Domains (6) summary
      cd08685
      Location:27146
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:9621075
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      COG0265
      Location:207262
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:188260
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16228
      Location:531697
      DUF4887; Domain of unknown function (DUF4887)
      cl23807
      Location:586659
      WWbp; WW-domain ligand protein
    6. XM_017015005.1XP_016870494.1  regulator of G-protein signaling 3 isoform X8

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    7. XM_011518900.1XP_011517202.1  regulator of G-protein signaling 3 isoform X8

      See identical proteins and their annotated locations for XP_011517202.1

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    8. XM_006717225.1XP_006717288.1  regulator of G-protein signaling 3 isoform X7

      Conserved Domains (1) summary
      cd08713
      Location:397510
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    9. XM_011518894.1XP_011517196.1  regulator of G-protein signaling 3 isoform X6

      Conserved Domains (1) summary
      cd08713
      Location:421534
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
    10. XM_006717226.2XP_006717289.1  regulator of G-protein signaling 3 isoform X8

      See identical proteins and their annotated locations for XP_006717289.1

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    11. XM_011518901.1XP_011517203.1  regulator of G-protein signaling 3 isoform X8

      See identical proteins and their annotated locations for XP_011517203.1

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    12. XM_011518898.1XP_011517200.1  regulator of G-protein signaling 3 isoform X8

      See identical proteins and their annotated locations for XP_011517200.1

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    13. XM_006717230.3XP_006717293.1  regulator of G-protein signaling 3 isoform X8

      See identical proteins and their annotated locations for XP_006717293.1

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    14. XM_011518896.1XP_011517198.1  regulator of G-protein signaling 3 isoform X8

      See identical proteins and their annotated locations for XP_011517198.1

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family
    15. XM_017015006.1XP_016870495.1  regulator of G-protein signaling 3 isoform X8

      UniProtKB/Swiss-Prot
      P49796
      UniProtKB/TrEMBL
      A0A024R831
      Conserved Domains (2) summary
      cd08713
      Location:395508
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      cl26464
      Location:20180
      Atrophin-1; Atrophin-1 family

    RNA

    1. XR_929831.1 RNA Sequence

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