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    RGS1 regulator of G protein signaling 1 [ Homo sapiens (human) ]

    Gene ID: 5996, updated on 6-Sep-2021


    Official Symbol
    RGS1provided by HGNC
    Official Full Name
    regulator of G protein signaling 1provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000090104 MIM:600323
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    1R20; BL34; IER1; IR20; HEL-S-87
    This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
    Broad expression in appendix (RPKM 110.9), lymph node (RPKM 72.3) and 17 other tissues See more
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    Genomic context

    See RGS1 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (192575773..192580024)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192544903..192549154)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily E member 1 pseudogene Neighboring gene regulator of G protein signaling 21 Neighboring gene uncharacterized LOC105371664 Neighboring gene uncharacterized LOC107985241 Neighboring gene regulator of G protein signaling 13

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?


    Associated conditions

    Description Tests
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    GeneReviews: Not available
    Multiple common variants for celiac disease influencing immune gene expression.
    GeneReviews: Not available
    Newly identified genetic risk variants for celiac disease related to the immune response.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of regulator of G-protein signaling 1 (RGS1) in human B cells PubMed
    Tat tat HIV-1 Tat upregulates the expression of regulator of G-protein signaling 1 (RGS1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    located_in plasma membrane TAS
    Traceable Author Statement
    more info

    General protein information

    Preferred Names
    regulator of G-protein signaling 1
    B-cell activation protein BL34
    early response protein 1R20
    epididymis secretory protein Li 87
    immediate-early response 1, B-cell specific
    regulator of G-protein signalling 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002922.4NP_002913.3  regulator of G-protein signaling 1

      See identical proteins and their annotated locations for NP_002913.3

      Status: REVIEWED

      Source sequence(s)
      AL136987, BC015510, BG536972
      Consensus CDS
      ENSP00000356429.3, ENST00000367459.8
      Conserved Domains (1) summary
      RGS_RGS1; Regulator of G protein signaling (RGS) domain found in the RGS1 protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)
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