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    RENBP renin binding protein [ Homo sapiens (human) ]

    Gene ID: 5973, updated on 2-Oct-2018

    Summary

    Official Symbol
    RENBPprovided by HGNC
    Official Full Name
    renin binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9959
    See related
    Ensembl:ENSG00000102032 MIM:312420; Vega:OTTHUMG00000024224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RBP; RNBP
    Summary
    The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 29.7), spleen (RPKM 23.5) and 18 other tissues See more
    Orthologs

    Genomic context

    See RENBP in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (153935263..153944780, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153200722..153210232, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 4 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene host cell factor C1 Neighboring gene HCFC1 antisense RNA 1 Neighboring gene transmembrane protein 187 Neighboring gene microRNA 3202-1 Neighboring gene microRNA 3202-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    N-acylglucosamine 2-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    N-acylglucosamine 2-epimerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    N-acylglucosamine 2-epimerase activity TAS
    Traceable Author Statement
    more info
     
    endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    N-acetylmannosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    N-acetylneuraminate catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    UDP-N-acetylglucosamine biosynthetic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    N-acylglucosamine 2-epimerase
    Names
    AGE
    GlcNAc 2-epimerase
    N-acetyl-D-glucosamine 2-epimerase
    NP_002901.2
    XP_016885187.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012522.1 RefSeqGene

      Range
      5001..14511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002910.5NP_002901.2  N-acylglucosamine 2-epimerase

      See identical proteins and their annotated locations for NP_002901.2

      Status: REVIEWED

      Source sequence(s)
      AK298125, BC015558, D10232, U52112
      Consensus CDS
      CCDS14738.2
      UniProtKB/Swiss-Prot
      P51606
      Related
      ENSP00000377303.3, OTTHUMP00000025998, ENST00000393700.7, OTTHUMT00000061103
      Conserved Domains (1) summary
      cd00249
      Location:14407
      AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      153935263..153944780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029698.1XP_016885187.1  N-acylglucosamine 2-epimerase isoform X1

      UniProtKB/Swiss-Prot
      P51606
      Conserved Domains (1) summary
      cd00249
      Location:4397
      AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...
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