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    CCNB1IP1 cyclin B1 interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 57820, updated on 19-May-2018
    Official Symbol
    CCNB1IP1provided by HGNC
    Official Full Name
    cyclin B1 interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:19437
    See related
    Ensembl:ENSG00000100814 MIM:608249; Vega:OTTHUMG00000029509
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEI10; C14orf18
    Summary
    HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]
    Expression
    Ubiquitous expression in ovary (RPKM 41.4), thyroid (RPKM 28.8) and 24 other tissues See more
    Orthologs
    See CCNB1IP1 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (20311368..20333312, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20779527..20801471, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene tetratricopeptide repeat domain 5 Neighboring gene small nucleolar RNA, H/ACA box 79B Neighboring gene small nucleolar RNA, C/D box 126 Neighboring gene poly(ADP-ribose) polymerase 2 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    blastocyst formation IEA
    Inferred from Electronic Annotation
    more info
     
    chiasma assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with synaptonemal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase CCNB1IP1
    Names
    RING-type E3 ubiquitin transferase CCNB1IP1
    cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
    human enhancer of invasion 10
    NP_067001.3
    NP_878269.1
    NP_878272.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021178.4NP_067001.3  E3 ubiquitin-protein ligase CCNB1IP1

      See identical proteins and their annotated locations for NP_067001.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2 and 4 encode the same protein.
      Source sequence(s)
      AF216381, AI301662, AK026233, DB029392
      Consensus CDS
      CCDS9547.1
      UniProtKB/Swiss-Prot
      Q9NPC3
      Related
      ENSP00000351810.4, OTTHUMP00000244397, ENST00000358932.8, OTTHUMT00000410358
      Conserved Domains (2) summary
      pfam14634
      Location:1052
      zf-RING_5; zinc-RING finger domain
      cl27218
      Location:100175
      OmpH; Outer membrane protein (OmpH-like)
    2. NM_182849.2NP_878269.1  E3 ubiquitin-protein ligase CCNB1IP1

      See identical proteins and their annotated locations for NP_878269.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AF216381, AI301662, BM741413, DB029392
      Consensus CDS
      CCDS9547.1
      UniProtKB/Swiss-Prot
      Q9NPC3
      Related
      ENSP00000337396.4, ENST00000353689.8
      Conserved Domains (2) summary
      pfam14634
      Location:1052
      zf-RING_5; zinc-RING finger domain
      cl27218
      Location:100175
      OmpH; Outer membrane protein (OmpH-like)
    3. NM_182852.3NP_878272.1  E3 ubiquitin-protein ligase CCNB1IP1

      See identical proteins and their annotated locations for NP_878272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AI301662, BC000369, BI763317, DB029392
      Consensus CDS
      CCDS9547.1
      UniProtKB/Swiss-Prot
      Q9NPC3
      Related
      ENSP00000409896.2, ENST00000437553.6
      Conserved Domains (2) summary
      pfam14634
      Location:1052
      zf-RING_5; zinc-RING finger domain
      cl27218
      Location:100175
      OmpH; Outer membrane protein (OmpH-like)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      20311368..20333312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182851.1: Suppressed sequence

      Description
      NM_182851.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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