Format

Send to:

Choose Destination
    • Showing Current items.

    TRIB3 tribbles pseudokinase 3 [ Homo sapiens (human) ]

    Gene ID: 57761, updated on 27-Sep-2020

    Summary

    Official Symbol
    TRIB3provided by HGNC
    Official Full Name
    tribbles pseudokinase 3provided by HGNC
    Primary source
    HGNC:HGNC:16228
    See related
    Ensembl:ENSG00000101255 MIM:607898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIPK; SINK; TRB3; SKIP3; C20orf97
    Summary
    The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues See more
    Orthologs

    Genomic context

    See TRIB3 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (380629..397559)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (356447..378203)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 12 Neighboring gene uncharacterized LOC101929937 Neighboring gene neurensin 2 Neighboring gene CRISPRi-validated cis-regulatory element chr20.29 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Whole genome association scan for genetic polymorphisms influencing information processing speed.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ubiquitin-protein transferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of protein kinase B signaling TAS
    Traceable Author Statement
    more info
     
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of glucose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tribbles homolog 3
    Names
    TRB-3
    neuronal cell death inducible putative kinase
    p65-interacting inhibitor of NF-kappa-B
    p65-interacting inhibitor of NF-kappaB

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301188.1NP_001288117.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288117.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as 1B1) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697937, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q96RU7
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    2. NM_001301190.1NP_001288119.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288119.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as 1B2) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697938, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q96RU7
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    3. NM_001301193.1NP_001288122.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as 1B3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697939, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q96RU7
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    4. NM_001301196.1NP_001288125.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288125.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as 1B4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697940, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q96RU7
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    5. NM_001301201.1NP_001288130.1  tribbles homolog 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate 5' UTR exon and an additional exon in the 5' region, which results in an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AJ697940, AK297546, BC019363
      Consensus CDS
      CCDS77554.1
      UniProtKB/Swiss-Prot
      Q96RU7
      UniProtKB/TrEMBL
      B4DMM9, J3KR25
      Related
      ENSP00000415416.2, ENST00000422053.3
      Conserved Domains (2) summary
      smart00220
      Location:107342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14024
      Location:101342
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    6. NM_021158.4NP_066981.2  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_066981.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as 1A) represents the longest transcript and encode the predominant isoform (1).
      Source sequence(s)
      AJ697936, AY247738, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q96RU7
      Related
      ENSP00000217233.3, ENST00000217233.8
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      380629..397559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027989.2XP_016883478.1  tribbles homolog 3 isoform X1

      UniProtKB/TrEMBL
      J3KR25
      Conserved Domains (2) summary
      smart00220
      Location:107342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14024
      Location:101342
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    Support Center