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    PTPN2 protein tyrosine phosphatase non-receptor type 2 [ Homo sapiens (human) ]

    Gene ID: 5771, updated on 5-May-2019

    Summary

    Official Symbol
    PTPN2provided by HGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 2provided by HGNC
    Primary source
    HGNC:HGNC:9650
    See related
    Ensembl:ENSG00000175354 MIM:176887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
    Expression
    Ubiquitous expression in appendix (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See PTPN2 in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (12785478..12884351, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12785477..12884337, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene proteasome assembly chaperone 2 Neighboring gene centrosomal protein 76 Neighboring gene long intergenic non-protein coding RNA 1882 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 1 Neighboring gene serine/threonine kinase 25 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    NHGRI GWA Catalog
    Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
    NHGRI GWA Catalog
    Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
    NHGRI GWA Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    NHGRI GWA Catalog
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    NHGRI GWA Catalog
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog
    Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
    NHGRI GWA Catalog
    Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Negative regulation of MET activity, organism-specific biosystem (from REACTOME)
      Negative regulation of MET activity, organism-specific biosystemSignaling by MET receptor is negatively regulated mainly by MET receptor dephosphorylation or MET receptor degradation. Protein tyrosine phosphatase PTPRJ dephosphorylates MET tyrosine residue Y1349,...
    • Regulation of IFNG signaling, organism-specific biosystem (from REACTOME)
      Regulation of IFNG signaling, organism-specific biosystemAt least three different classes of negative regulators exist to control the extent of INFG stimulation and signaling. These include the feedback inhibitors belonging to protein family suppressors of...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by MET, organism-specific biosystem (from REACTOME)
      Signaling by MET, organism-specific biosystemMET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    STAT family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to cytokine stimulus TAS
    Traceable Author Statement
    more info
     
    erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interferon-gamma-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-2-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-4-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of macrophage colony-stimulating factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of positive thymic T cell selection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of PERK-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 2
    Names
    T-cell protein tyrosine phosphatase
    NP_001193942.1
    NP_001295216.1
    NP_002819.2
    NP_536347.1
    NP_536348.1
    XP_005258181.1
    XP_005258182.1
    XP_011524007.1
    XP_011524008.1
    XP_011524009.1
    XP_016881373.1
    XP_016881374.1
    XP_016881375.1
    XP_016881376.1
    XP_016881377.1
    XP_024306996.1
    XP_024306997.1
    XP_024306998.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029116.1 RefSeqGene

      Range
      5001..103858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207013.1NP_001193942.1  tyrosine-protein phosphatase non-receptor type 2 isoform 4

      See identical proteins and their annotated locations for NP_001193942.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional in-frame exon in the middle coding region and an alternate 3' region, which includes a part of the C-terminal coding region, when compared to variant 1. The resulting isoform (4) has an additional internal segment and a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK225706, BG699440, BQ010946
      Consensus CDS
      CCDS59306.1
      UniProtKB/Swiss-Prot
      P17706
      Related
      ENSP00000466936.1, ENST00000591115.5
      Conserved Domains (2) summary
      cd00047
      Location:45297
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:42297
      Y_phosphatase; Protein-tyrosine phosphatase
    2. NM_001308287.1NP_001295216.1  tyrosine-protein phosphatase non-receptor type 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an alternate start codon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AB209569, AP001077
      Consensus CDS
      CCDS77155.1
      UniProtKB/TrEMBL
      K7EQG9, Q59F91
      Related
      ENSP00000467823.1, ENST00000591497.5
      Conserved Domains (2) summary
      cd00047
      Location:26245
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:26245
      Y_phosphatase; Protein-tyrosine phosphatase
    3. NM_002828.4NP_002819.2  tyrosine-protein phosphatase non-receptor type 2 isoform 1

      See identical proteins and their annotated locations for NP_002819.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB209569, AK292570, AP001077, BG699440, DB350067
      Consensus CDS
      CCDS11865.1
      UniProtKB/Swiss-Prot
      P17706
      UniProtKB/TrEMBL
      Q59F91
      Related
      ENSP00000311857.3, ENST00000309660.10
      Conserved Domains (2) summary
      smart00194
      Location:5274
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:45274
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. NM_080422.2NP_536347.1  tyrosine-protein phosphatase non-receptor type 2 isoform 2

      See identical proteins and their annotated locations for NP_536347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' region, which includes a part of the C-terminal coding region, when compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK290649, BG699440, BQ010946
      Consensus CDS
      CCDS11863.1
      UniProtKB/Swiss-Prot
      P17706
      UniProtKB/TrEMBL
      A8K3N4
      Related
      ENSP00000320298.3, ENST00000327283.7
      Conserved Domains (1) summary
      pfam00102
      Location:42274
      Y_phosphatase; Protein-tyrosine phosphatase
    5. NM_080423.2NP_536348.1  tyrosine-protein phosphatase non-receptor type 2 isoform 3

      See identical proteins and their annotated locations for NP_536348.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' region, which includes a part of the C-terminal coding region, when compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC016727, BG699440, BQ010946
      Consensus CDS
      CCDS11864.1
      UniProtKB/Swiss-Prot
      P17706
      Related
      ENSP00000320546.3, ENST00000353319.8
      Conserved Domains (2) summary
      smart00194
      Location:5274
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:45274
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

      Range
      12785478..12884351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258125.4XP_005258182.1  tyrosine-protein phosphatase non-receptor type 2 isoform X2

      Conserved Domains (2) summary
      cd00047
      Location:45297
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:42297
      Y_phosphatase; Protein-tyrosine phosphatase
    2. XM_017025888.2XP_016881377.1  tyrosine-protein phosphatase non-receptor type 2 isoform X10

      Conserved Domains (2) summary
      cd00047
      Location:1175
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:1175
      Y_phosphatase; Protein-tyrosine phosphatase
    3. XM_024451228.1XP_024306996.1  tyrosine-protein phosphatase non-receptor type 2 isoform X7

      Conserved Domains (1) summary
      pfam00102
      Location:42229
      Y_phosphatase; Protein-tyrosine phosphatase
    4. XM_017025884.1XP_016881373.1  tyrosine-protein phosphatase non-receptor type 2 isoform X4

    5. XM_017025887.2XP_016881376.1  tyrosine-protein phosphatase non-receptor type 2 isoform X9

    6. XM_005258124.4XP_005258181.1  tyrosine-protein phosphatase non-receptor type 2 isoform X1

      Conserved Domains (2) summary
      cd00047
      Location:45297
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:42297
      Y_phosphatase; Protein-tyrosine phosphatase
    7. XM_017025886.1XP_016881375.1  tyrosine-protein phosphatase non-receptor type 2 isoform X8

      UniProtKB/TrEMBL
      D3DUJ3
      Conserved Domains (1) summary
      cd00047
      Location:1175
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    8. XM_011525706.2XP_011524008.1  tyrosine-protein phosphatase non-receptor type 2 isoform X6

      Conserved Domains (2) summary
      cd00047
      Location:45229
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:42229
      Y_phosphatase; Protein-tyrosine phosphatase
    9. XM_011525705.3XP_011524007.1  tyrosine-protein phosphatase non-receptor type 2 isoform X3

      Conserved Domains (2) summary
      cd00047
      Location:26268
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:26268
      Y_phosphatase; Protein-tyrosine phosphatase
    10. XM_017025885.2XP_016881374.1  tyrosine-protein phosphatase non-receptor type 2 isoform X5

      UniProtKB/TrEMBL
      K7EQG9
      Conserved Domains (2) summary
      cd00047
      Location:26245
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:26245
      Y_phosphatase; Protein-tyrosine phosphatase
    11. XM_024451229.1XP_024306997.1  tyrosine-protein phosphatase non-receptor type 2 isoform X8

      Related
      ENSP00000493693.1, ENST00000645191.1
      Conserved Domains (1) summary
      cd00047
      Location:1175
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    12. XM_024451230.1XP_024306998.1  tyrosine-protein phosphatase non-receptor type 2 isoform X8

      Related
      ENSP00000496181.1, ENST00000646492.1
      Conserved Domains (1) summary
      cd00047
      Location:1175
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    13. XM_011525707.2XP_011524009.1  tyrosine-protein phosphatase non-receptor type 2 isoform X11

      Conserved Domains (2) summary
      cd00047
      Location:8118
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:9118
      Y_phosphatase; Protein-tyrosine phosphatase
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