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    SH3RF1 SH3 domain containing ring finger 1 [ Homo sapiens (human) ]

    Gene ID: 57630, updated on 7-Dec-2018

    Summary

    Official Symbol
    SH3RF1provided by HGNC
    Official Full Name
    SH3 domain containing ring finger 1provided by HGNC
    Primary source
    HGNC:HGNC:17650
    See related
    Ensembl:ENSG00000154447
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POSH; RNF142; SH3MD2
    Summary
    This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.9), stomach (RPKM 11.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See SH3RF1 in Genome Data Viewer
    Location:
    4q32.3-q33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (169094256..169271098, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (170015407..170192249, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 4 Neighboring gene RNY4 pseudogene 17 Neighboring gene uncharacterized LOC105377527 Neighboring gene ribosomal protein L6 pseudogene 12 Neighboring gene uncharacterized LOC105377529 Neighboring gene NIMA related kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag ALIX is an ubiquitination substrate of the ubiquitin E3-ligase POSH and POSH and ALIX cooperate to facilitate efficient HIV-1 release, suggesting the interaction between HIV-1 Gag and POSH and POSH may be functionally auxiliary for viral release PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21602, KIAA1494

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MAP-kinase scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of CD4-positive, alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of CD8-positive, alpha-beta T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase SH3RF1
    Names
    RING-type E3 ubiquitin transferase SH3RF1
    SH3 domain-containing RING finger protein 1
    SH3 multiple domains 2
    SH3 multiple domains protein 2
    plenty of SH3 domains
    plenty of SH3s
    putative E3 ubiquitin-protein ligase SH3RF1
    ring finger protein 142
    NP_065921.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020870.4NP_065921.2  E3 ubiquitin-protein ligase SH3RF1

      See identical proteins and their annotated locations for NP_065921.2

      Status: REVIEWED

      Source sequence(s)
      AC021151, AC096741, AC104783
      Consensus CDS
      CCDS34099.1
      UniProtKB/Swiss-Prot
      Q7Z6J0
      Related
      ENSP00000284637.9, ENST00000284637.13
      Conserved Domains (5) summary
      cd11785
      Location:833887
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11926
      Location:449503
      SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
      cd11930
      Location:200254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      cd00162
      Location:1156
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl17036
      Location:137190
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      169094256..169271098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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