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    PTK2 protein tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 5747, updated on 23-Oct-2021

    Summary

    Official Symbol
    PTK2provided by HGNC
    Official Full Name
    protein tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:9611
    See related
    Ensembl:ENSG00000169398 MIM:600758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAK; FADK; FAK1; FRNK; FADK 1; PPP1R71; p125FAK; pp125FAK
    Summary
    This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTK2 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (140657900..141002079, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141667999..142012178, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene argonaute RISC catalytic component 2 Neighboring gene MAGE-like protein 2 Neighboring gene E2F1-regulated inhibitor of cell death Neighboring gene microRNA 151a Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene Sharpr-MPRA regulatory region 10587 Neighboring gene uncharacterized LOC105375783 Neighboring gene Sharpr-MPRA regulatory region 11335 Neighboring gene uncharacterized LOC105375784

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-stimulated cells overexpressing NHERF1 upregulates FAK phosphorylation PubMed
    env Focal adhesion kinase (FAK), CD4, and HIV-1 gp120 co-localize in T cells. The formation of FAK-CD4 complex is induced by gp120 PubMed
    Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
    tat Focal adhesion kinase (FAK) is tyrosine-phosphorylated by Tat, and inhibition of FAK by the dominant interfering mutant form, FAK-related nonkinase, significantly blocks HBMEC migration and disrupted focal adhesions upon Tat activation PubMed
    tat HIV-1 Tat upregulates p125FAK and induces the tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 neuronal cells PubMed
    tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in detection of muscle stretch TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in netrin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in placenta development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of positive regulation of macrophage chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of positive regulation of macrophage proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of epithelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of focal adhesion assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of focal adhesion assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of substrate adhesion-dependent cell spreading IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    focal adhesion kinase 1
    Names
    FAK-related non-kinase polypeptide
    PTK2 protein tyrosine kinase 2
    focal adhesion kinase-related nonkinase
    protein phosphatase 1 regulatory subunit 71
    NP_001186578.1
    NP_001303271.1
    NP_001339623.1
    NP_001339624.1
    NP_001339625.1
    NP_001339626.1
    NP_001339627.1
    NP_001339628.1
    NP_001339629.1
    NP_001339630.1
    NP_001339631.1
    NP_001339632.1
    NP_001339633.1
    NP_001339634.1
    NP_001339635.1
    NP_001339636.1
    NP_001339637.1
    NP_001339638.1
    NP_001339639.1
    NP_001339640.1
    NP_001339641.1
    NP_001339642.1
    NP_001339643.1
    NP_001339644.1
    NP_001339645.1
    NP_001339646.1
    NP_001339647.1
    NP_001339648.1
    NP_001339649.1
    NP_001339650.1
    NP_001339651.1
    NP_001339652.1
    NP_001339653.1
    NP_001339654.1
    NP_001339655.1
    NP_001339656.1
    NP_001339657.1
    NP_001339658.1
    NP_001339659.1
    NP_001339660.1
    NP_001339661.1
    NP_001339662.1
    NP_001339663.1
    NP_001339664.1
    NP_001339665.1
    NP_001339666.1
    NP_001339667.1
    NP_001339668.1
    NP_001339669.1
    NP_001339670.1
    NP_001339671.1
    NP_001339672.1
    NP_001339673.1
    NP_001339674.1
    NP_001339675.1
    NP_001339676.1
    NP_001339677.1
    NP_001339678.1
    NP_001339679.1
    NP_001339680.1
    NP_001339681.1
    NP_001374513.1
    NP_001374514.1
    NP_001374515.1
    NP_001374516.1
    NP_001374517.1
    NP_001374518.1
    NP_001374519.1
    NP_001374520.1
    NP_001374521.1
    NP_001374532.1
    NP_001374533.1
    NP_001374534.1
    NP_001374535.1
    NP_001374536.1
    NP_001374537.1
    NP_001374538.1
    NP_001374539.1
    NP_001374540.1
    NP_001374541.1
    NP_001374542.1
    NP_001374543.1
    NP_001374544.1
    NP_001374545.1
    NP_001374546.1
    NP_001374547.1
    NP_001374548.1
    NP_001374549.1
    NP_001374550.1
    NP_001374551.1
    NP_001374552.1
    NP_001374553.1
    NP_001374554.1
    NP_001374556.1
    NP_001374557.1
    NP_001374558.1
    NP_001374559.1
    NP_001374560.1
    NP_001374561.1
    NP_001374562.1
    NP_001374563.1
    NP_001374564.1
    NP_001374565.1
    NP_001374566.1
    NP_001374567.1
    NP_001374568.1
    NP_001374569.1
    NP_001374570.1
    NP_001374571.1
    NP_001374572.1
    NP_001374573.1
    NP_001374574.1
    NP_001374575.1
    NP_001374576.1
    NP_001374577.1
    NP_001374578.1
    NP_001374579.1
    NP_001374580.1
    NP_001374581.1
    NP_001374582.1
    NP_001374583.1
    NP_001374584.1
    NP_001374585.1
    NP_001374586.1
    NP_001374587.1
    NP_001374588.1
    NP_001374589.1
    NP_001374590.1
    NP_001374591.1
    NP_005598.3
    NP_722560.1
    XP_016869143.1
    XP_016869145.1
    XP_016869155.1
    XP_016869158.1
    XP_016869173.1
    XP_016869177.1
    XP_024302967.1
    XP_024302968.1
    XP_024302969.1
    XP_024302970.1
    XP_024302971.1
    XP_024302972.1
    XP_024302973.1
    XP_024302974.1
    XP_024302975.1
    XP_024302976.1
    XP_024302977.1
    XP_024302978.1
    XP_024302979.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029467.2 RefSeqGene

      Range
      5032..348414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199649.2NP_001186578.1  focal adhesion kinase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, and contains two additional in-frame segments near the 3' end of the coding sequence, compared to variant 2. The resulting isoform (c) is shorter at the N-terminus and contains two additional segments in the C-terminus compared to isoform b.
      Source sequence(s)
      AB209083, AC067931, AK304356, AL832961, BF434494, DA236314, DA994616
      Consensus CDS
      CCDS56557.1
      UniProtKB/Swiss-Prot
      Q05397
      UniProtKB/TrEMBL
      Q59GM6, Q658W2
      Related
      ENSP00000341189.3, ENST00000340930.7
      Conserved Domains (6) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9291058
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:422676
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001316342.2NP_001303271.1  focal adhesion kinase 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons and contains two other alternate in-frame exons compared to variant 2. The resulting isoform (d) differs in the 5' UTR, has a shorter and distinct N-terminus, and contains two alternative segments compared to isoform b. Variants 4 and 7 both encode the same isoform (d).
      Source sequence(s)
      AB209071, AC067931, BF434494, BY800117
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819948
      Focal_AT; Focal adhesion targeting region
    3. NM_001352694.2NP_001339623.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 1, encodes isoform a.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    4. NM_001352695.2NP_001339624.1  focal adhesion kinase 1 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:449718
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9291058
      Focal_AT; Focal adhesion targeting region
    5. NM_001352696.2NP_001339625.1  focal adhesion kinase 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 4, encodes isoform d.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819948
      Focal_AT; Focal adhesion targeting region
    6. NM_001352697.2NP_001339626.1  focal adhesion kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9801109
      Focal_AT; Focal adhesion targeting region
    7. NM_001352698.2NP_001339627.1  focal adhesion kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:469738
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49271
      B41; Band 4.1 homologues
      cd13190
      Location:267377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9731102
      Focal_AT; Focal adhesion targeting region
    8. NM_001352699.2NP_001339628.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 11-14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    9. NM_001352700.2NP_001339629.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 10 and 12-14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    10. NM_001352701.2NP_001339630.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 10, 11, 13, and 14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    11. NM_001352702.2NP_001339631.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 10-12 and 14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    12. NM_001352703.2NP_001339632.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 10-13, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    13. NM_001352704.2NP_001339633.1  focal adhesion kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:449718
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9531082
      Focal_AT; Focal adhesion targeting region
    14. NM_001352705.2NP_001339634.1  focal adhesion kinase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:441710
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49271
      B41; Band 4.1 homologues
      cd13190
      Location:267377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9451074
      Focal_AT; Focal adhesion targeting region
    15. NM_001352706.2NP_001339635.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 18-21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    16. NM_001352707.2NP_001339636.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 17 and 19-21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    17. NM_001352708.2NP_001339637.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 17,18, 20, and 21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    18. NM_001352709.2NP_001339638.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 17-19 and 21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    19. NM_001352710.2NP_001339639.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 17-20, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    20. NM_001352711.2NP_001339640.1  focal adhesion kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:427696
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9311060
      Focal_AT; Focal adhesion targeting region
    21. NM_001352712.2NP_001339641.1  focal adhesion kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9571086
      Focal_AT; Focal adhesion targeting region
    22. NM_001352713.2NP_001339642.1  focal adhesion kinase 1 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform m.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
    23. NM_001352714.2NP_001339643.1  focal adhesion kinase 1 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform m.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
    24. NM_001352715.2NP_001339644.1  focal adhesion kinase 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9251054
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    25. NM_001352716.2NP_001339645.1  focal adhesion kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:420689
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9241053
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    26. NM_001352717.2NP_001339646.1  focal adhesion kinase 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9221051
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    27. NM_001352718.2NP_001339647.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    28. NM_001352719.2NP_001339648.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    29. NM_001352720.2NP_001339649.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    30. NM_001352721.2NP_001339650.1  focal adhesion kinase 1 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 33 and 34, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111040
      Focal_AT; Focal adhesion targeting region
    31. NM_001352722.2NP_001339651.1  focal adhesion kinase 1 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 32 and 34, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111040
      Focal_AT; Focal adhesion targeting region
    32. NM_001352723.2NP_001339652.1  focal adhesion kinase 1 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variants 32 and 33, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111040
      Focal_AT; Focal adhesion targeting region
    33. NM_001352724.2NP_001339653.1  focal adhesion kinase 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321034
      Focal_AT; Focal adhesion targeting region
    34. NM_001352725.2NP_001339654.1  focal adhesion kinase 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8981027
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    35. NM_001352726.2NP_001339655.1  focal adhesion kinase 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:392661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8961025
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    36. NM_001352727.2NP_001339656.1  focal adhesion kinase 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111013
      Focal_AT; Focal adhesion targeting region
    37. NM_001352728.2NP_001339657.1  focal adhesion kinase 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:379648
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8801009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    38. NM_001352729.2NP_001339658.1  focal adhesion kinase 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:392661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8751004
      Focal_AT; Focal adhesion targeting region
    39. NM_001352730.2NP_001339659.1  focal adhesion kinase 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:847976
      Focal_AT; Focal adhesion targeting region
    40. NM_001352731.2NP_001339660.1  focal adhesion kinase 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:845974
      Focal_AT; Focal adhesion targeting region
    41. NM_001352732.2NP_001339661.1  focal adhesion kinase 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:844973
      Focal_AT; Focal adhesion targeting region
    42. NM_001352733.2NP_001339662.1  focal adhesion kinase 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:336605
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:840969
      Focal_AT; Focal adhesion targeting region
    43. NM_001352734.2NP_001339663.1  focal adhesion kinase 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:826955
      Focal_AT; Focal adhesion targeting region
    44. NM_001352735.2NP_001339664.1  focal adhesion kinase 1 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:322591
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9124
      B41; Band 4.1 homologues
      cd13190
      Location:120230
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:826955
      Focal_AT; Focal adhesion targeting region
    45. NM_001352736.2NP_001339665.1  focal adhesion kinase 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:320589
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16157
      B41; Band 4.1 homologues
      cd13190
      Location:153263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:824953
      Focal_AT; Focal adhesion targeting region
    46. NM_001352737.2NP_001339666.1  focal adhesion kinase 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:336605
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:837966
      Focal_AT; Focal adhesion targeting region
    47. NM_001352738.2NP_001339667.1  focal adhesion kinase 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:817946
      Focal_AT; Focal adhesion targeting region
    48. NM_001352739.2NP_001339668.1  focal adhesion kinase 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:309578
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:813942
      Focal_AT; Focal adhesion targeting region
    49. NM_001352740.2NP_001339669.1  focal adhesion kinase 1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      cd05056
      Location:308577
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    50. NM_001352741.2NP_001339670.1  focal adhesion kinase 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806935
      Focal_AT; Focal adhesion targeting region
    51. NM_001352742.2NP_001339671.1  focal adhesion kinase 1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:294563
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9124
      B41; Band 4.1 homologues
      cd13190
      Location:120230
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:798927
      Focal_AT; Focal adhesion targeting region
    52. NM_001352743.2NP_001339672.1  focal adhesion kinase 1 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:798927
      Focal_AT; Focal adhesion targeting region
    53. NM_001352744.2NP_001339673.1  focal adhesion kinase 1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:279548
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:783912
      Focal_AT; Focal adhesion targeting region
    54. NM_001352745.2NP_001339674.1  focal adhesion kinase 1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:273542
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:777906
      Focal_AT; Focal adhesion targeting region
    55. NM_001352746.2NP_001339675.1  focal adhesion kinase 1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:258527
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9124
      B41; Band 4.1 homologues
      cd13190
      Location:120194
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:762891
      Focal_AT; Focal adhesion targeting region
    56. NM_001352747.2NP_001339676.1  focal adhesion kinase 1 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (2) summary
      pfam03623
      Location:445574
      Focal_AT; Focal adhesion targeting region
      cl21453
      Location:1210
      PKc_like; Protein Kinases, catalytic domain
    57. NM_001352748.2NP_001339677.1  focal adhesion kinase 1 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cl21453
      Location:428496
      PKc_like; Protein Kinases, catalytic domain
    58. NM_001352749.2NP_001339678.1  focal adhesion kinase 1 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:229358
      Focal_AT; Focal adhesion targeting region
    59. NM_001352750.2NP_001339679.1  focal adhesion kinase 1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Consensus CDS
      CCDS87628.1
      Related
      ENSP00000403416.2, ENST00000430260.6
      Conserved Domains (1) summary
      pfam03623
      Location:226355
      Focal_AT; Focal adhesion targeting region
    60. NM_001352751.2NP_001339680.1  focal adhesion kinase 1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:208337
      Focal_AT; Focal adhesion targeting region
    61. NM_001352752.2NP_001339681.1  focal adhesion kinase 1 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:205334
      Focal_AT; Focal adhesion targeting region
    62. NM_001387584.1NP_001374513.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    63. NM_001387585.1NP_001374514.1  focal adhesion kinase 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8951024
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    64. NM_001387586.1NP_001374515.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000429929.1, ENST00000519654.5
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    65. NM_001387587.1NP_001374516.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    66. NM_001387588.1NP_001374517.1  focal adhesion kinase 1 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009
      Related
      ENSP00000430044.1, ENST00000520045.5
      Conserved Domains (1) summary
      pfam18038
      Location:35121
      FERM_N_2; FERM N-terminal domain
    67. NM_001387589.1NP_001374518.1  focal adhesion kinase 1 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009
      Conserved Domains (1) summary
      pfam18038
      Location:48134
      FERM_N_2; FERM N-terminal domain
    68. NM_001387590.1NP_001374519.1  focal adhesion kinase 1 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:266535
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:767896
      Focal_AT; Focal adhesion targeting region
    69. NM_001387591.1NP_001374520.1  focal adhesion kinase 1 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:782911
      Focal_AT; Focal adhesion targeting region
    70. NM_001387592.1NP_001374521.1  focal adhesion kinase 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000428492.1, ENST00000523539.5
      Conserved Domains (3) summary
      cd05056
      Location:101370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:150
      PH-like; Pleckstrin homology-like domain
    71. NM_001387603.1NP_001374532.1  focal adhesion kinase 1 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:785914
      Focal_AT; Focal adhesion targeting region
    72. NM_001387604.1NP_001374533.1  focal adhesion kinase 1 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      cd05056
      Location:101370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:605734
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:150
      PH-like; Pleckstrin homology-like domain
    73. NM_001387605.1NP_001374534.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    74. NM_001387606.1NP_001374535.1  focal adhesion kinase 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:309578
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:813942
      Focal_AT; Focal adhesion targeting region
    75. NM_001387607.1NP_001374536.1  focal adhesion kinase 1 isofom 58

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:816945
      Focal_AT; Focal adhesion targeting region
    76. NM_001387608.1NP_001374537.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    77. NM_001387609.1NP_001374538.1  focal adhesion kinase 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806935
      Focal_AT; Focal adhesion targeting region
    78. NM_001387610.1NP_001374539.1  focal adhesion kinase 1 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:241510
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:1884
      B41; Band 4.1 homologues
      cd13190
      Location:80190
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:742871
      Focal_AT; Focal adhesion targeting region
    79. NM_001387611.1NP_001374540.1  focal adhesion kinase 1 isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:308577
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:809938
      Focal_AT; Focal adhesion targeting region
    80. NM_001387612.1NP_001374541.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    81. NM_001387613.1NP_001374542.1  focal adhesion kinase 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806935
      Focal_AT; Focal adhesion targeting region
    82. NM_001387614.1NP_001374543.1  focal adhesion kinase 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8951024
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    83. NM_001387615.1NP_001374544.1  focal adhesion kinase 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:392661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8961025
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    84. NM_001387616.1NP_001374545.1  focal adhesion kinase 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      cd05056
      Location:101370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:150
      PH-like; Pleckstrin homology-like domain
    85. NM_001387617.1NP_001374546.1  focal adhesion kinase 1 isoform 67

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      cd05056
      Location:101370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:150
      PH-like; Pleckstrin homology-like domain
    86. NM_001387618.1NP_001374547.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    87. NM_001387619.1NP_001374548.1  focal adhesion kinase 1 isoform 66

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:379648
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8801009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    88. NM_001387620.1NP_001374549.1  focal adhesion kinase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819948
      Focal_AT; Focal adhesion targeting region
    89. NM_001387621.1NP_001374550.1  focal adhesion kinase 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      cd05056
      Location:101370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:150
      PH-like; Pleckstrin homology-like domain
    90. NM_001387622.1NP_001374551.1  focal adhesion kinase 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9221051
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    91. NM_001387623.1NP_001374552.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    92. NM_001387624.1NP_001374553.1  focal adhesion kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:420689
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9241053
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    93. NM_001387625.1NP_001374554.1  focal adhesion kinase 1 isofom 20

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8981027
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    94. NM_001387627.1NP_001374556.1  focal adhesion kinase 1 isofom 60

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9011030
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    95. NM_001387628.1NP_001374557.1  focal adhesion kinase 1 isofom 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000429474.1, ENST00000521059.5
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    96. NM_001387629.1NP_001374558.1  focal adhesion kinase 1 isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000430603.1, ENST00000521986.5
      Conserved Domains (3) summary
      cd05056
      Location:107376
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:611740
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:150
      PH-like; Pleckstrin homology-like domain
    97. NM_001387630.1NP_001374559.1  focal adhesion kinase 1 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:241510
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:1884
      B41; Band 4.1 homologues
      cd13190
      Location:80190
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:742871
      Focal_AT; Focal adhesion targeting region
    98. NM_001387631.1NP_001374560.1  focal adhesion kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:420689
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9241053
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    99. NM_001387632.1NP_001374561.1  focal adhesion kinase 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8951024
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    100. NM_001387633.1NP_001374562.1  focal adhesion kinase 1 isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9051034
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    101. NM_001387634.1NP_001374563.1  focal adhesion kinase 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9251054
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    102. NM_001387635.1NP_001374564.1  focal adhesion kinase 1 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:266535
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:767896
      Focal_AT; Focal adhesion targeting region
    103. NM_001387636.1NP_001374565.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    104. NM_001387637.1NP_001374566.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000378644.3, ENST00000395218.3
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    105. NM_001387638.1NP_001374567.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    106. NM_001387639.1NP_001374568.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    107. NM_001387640.1NP_001374569.1  focal adhesion kinase 1 isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9391068
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    108. NM_001387641.1NP_001374570.1  focal adhesion kinase 1 isoform 72

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49271
      B41; Band 4.1 homologues
      cd13190
      Location:267377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9291058
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:48143
      FERM_N_2; FERM N-terminal domain
    109. NM_001387642.1NP_001374571.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    110. NM_001387643.1NP_001374572.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    111. NM_001387644.1NP_001374573.1  focal adhesion kinase 1 isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:462731
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49271
      B41; Band 4.1 homologues
      cd13190
      Location:267377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9661095
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:48143
      FERM_N_2; FERM N-terminal domain
    112. NM_001387645.1NP_001374574.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    113. NM_001387646.1NP_001374575.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    114. NM_001387647.1NP_001374576.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    115. NM_001387648.1NP_001374577.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    116. NM_001387649.1NP_001374578.1  focal adhesion kinase 1 isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    117. NM_001387650.1NP_001374579.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    118. NM_001387651.1NP_001374580.1  focal adhesion kinase 1 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009
      Related
      ENSP00000427904.1, ENST00000520892.5
      Conserved Domains (1) summary
      pfam18038
      Location:35121
      FERM_N_2; FERM N-terminal domain
    119. NM_001387652.1NP_001374581.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    120. NM_001387653.1NP_001374582.1  focal adhesion kinase 1 isoform 73

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:379648
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8801009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    121. NM_001387654.1NP_001374583.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803932
      Focal_AT; Focal adhesion targeting region
    122. NM_001387655.1NP_001374584.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    123. NM_001387656.1NP_001374585.1  focal adhesion kinase 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8981027
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    124. NM_001387657.1NP_001374586.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    125. NM_001387658.1NP_001374587.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    126. NM_001387659.1NP_001374588.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    127. NM_001387660.1NP_001374589.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000429082.1, ENST00000517887.5
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    128. NM_001387661.1NP_001374590.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    129. NM_001387662.1NP_001374591.1  focal adhesion kinase 1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (5) summary
      cd05056
      Location:459728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9631092
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79174
      FERM_N_2; FERM N-terminal domain
    130. NM_005607.5NP_005598.3  focal adhesion kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_005598.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AB209083, AC067931, AC100860, AL832961, BF434494, DA236314
      UniProtKB/TrEMBL
      Q59GM6, Q658W2
      Conserved Domains (6) summary
      cd05056
      Location:437706
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:58280
      B41; Band 4.1 homologues
      cd13190
      Location:276386
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:165270
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9381067
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:444698
      Pkinase_Tyr; Protein tyrosine kinase
    131. NM_153831.4NP_722560.1  focal adhesion kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_722560.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1 and 5 both encode the same isoform (a).
      Source sequence(s)
      AB209083, AC067931, AL832961, BF434494, DA236314, L13616
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      Q05397
      UniProtKB/TrEMBL
      Q59GM6, Q658W2
      Related
      ENSP00000429911.1, ENST00000522684.5
      Conserved Domains (5) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain

    RNA

    1. NR_148036.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
    2. NR_148037.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
    3. NR_148038.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
    4. NR_148039.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
    5. NR_170670.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC100860
    6. NR_170671.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENST00000519993.5
    7. NR_170672.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
    8. NR_170673.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      140657900..141002079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447210.1XP_024302978.1  focal adhesion kinase 1 isoform X16

      Conserved Domains (4) summary
      cd05056
      Location:443712
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
    2. XM_024447207.1XP_024302975.1  focal adhesion kinase 1 isoform X13

      Conserved Domains (4) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9491078
      Focal_AT; Focal adhesion targeting region
    3. XM_024447206.1XP_024302974.1  focal adhesion kinase 1 isoform X12

      Conserved Domains (4) summary
      cd05056
      Location:479748
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9621091
      Focal_AT; Focal adhesion targeting region
    4. XM_024447205.1XP_024302973.1  focal adhesion kinase 1 isoform X9

      Conserved Domains (4) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9671096
      Focal_AT; Focal adhesion targeting region
    5. XM_024447203.1XP_024302971.1  focal adhesion kinase 1 isoform X6

      Conserved Domains (4) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9731102
      Focal_AT; Focal adhesion targeting region
    6. XM_017013666.1XP_016869155.1  focal adhesion kinase 1 isoform X18

    7. XM_017013669.2XP_016869158.1  focal adhesion kinase 1 isoform X19

    8. XM_024447202.1XP_024302970.1  focal adhesion kinase 1 isoform X5

      Conserved Domains (4) summary
      cd05056
      Location:473742
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9741103
      Focal_AT; Focal adhesion targeting region
    9. XM_017013656.2XP_016869145.1  focal adhesion kinase 1 isoform X10

    10. XM_017013688.2XP_016869177.1  focal adhesion kinase 1 isoform X23

      Conserved Domains (4) summary
      cd05056
      Location:279548
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:783912
      Focal_AT; Focal adhesion targeting region
    11. XM_017013684.2XP_016869173.1  focal adhesion kinase 1 isoform X21

      Conserved Domains (4) summary
      cd05056
      Location:309578
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:813942
      Focal_AT; Focal adhesion targeting region
    12. XM_024447211.1XP_024302979.1  focal adhesion kinase 1 isoform X20

      Conserved Domains (5) summary
      cd05056
      Location:392661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8961025
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35130
      FERM_N_2; FERM N-terminal domain
    13. XM_024447209.1XP_024302977.1  focal adhesion kinase 1 isoform X15

      Conserved Domains (4) summary
      cd05056
      Location:437706
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9411070
      Focal_AT; Focal adhesion targeting region
    14. XM_024447208.1XP_024302976.1  focal adhesion kinase 1 isoform X14

      Conserved Domains (4) summary
      cd05056
      Location:443712
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9471076
      Focal_AT; Focal adhesion targeting region
    15. XM_024447200.1XP_024302968.1  focal adhesion kinase 1 isoform X2

      Conserved Domains (4) summary
      cd05056
      Location:473742
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9771106
      Focal_AT; Focal adhesion targeting region
    16. XM_024447199.1XP_024302967.1  focal adhesion kinase 1 isoform X1

      Conserved Domains (4) summary
      cd05056
      Location:479748
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9831112
      Focal_AT; Focal adhesion targeting region
    17. XM_017013654.2XP_016869143.1  focal adhesion kinase 1 isoform X8

    18. XM_024447204.1XP_024302972.1  focal adhesion kinase 1 isoform X7

      Conserved Domains (4) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9701099
      Focal_AT; Focal adhesion targeting region
    19. XM_024447201.1XP_024302969.1  focal adhesion kinase 1 isoform X3

      Conserved Domains (4) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9761105
      Focal_AT; Focal adhesion targeting region
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