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    PTK2 protein tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 5747, updated on 15-Jun-2019

    Summary

    Official Symbol
    PTK2provided by HGNC
    Official Full Name
    protein tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:9611
    See related
    Ensembl:ENSG00000169398 MIM:600758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAK; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK
    Summary
    This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See PTK2 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (140658382..141002079, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141668481..142011412, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene argonaute RISC catalytic component 2 Neighboring gene MAGE-like protein 2 Neighboring gene microRNA 151a Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene uncharacterized LOC105375783 Neighboring gene uncharacterized LOC105375784

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-stimulated cells overexpressing NHERF1 upregulates FAK phosphorylation PubMed
    env Focal adhesion kinase (FAK), CD4, and HIV-1 gp120 co-localize in T cells. The formation of FAK-CD4 complex is induced by gp120 PubMed
    Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
    tat Focal adhesion kinase (FAK) is tyrosine-phosphorylated by Tat, and inhibition of FAK by the dominant interfering mutant form, FAK-related nonkinase, significantly blocks HBMEC migration and disrupted focal adhesions upon Tat activation PubMed
    tat HIV-1 Tat upregulates p125FAK and induces the tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 neuronal cells PubMed
    tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • ARMS-mediated activation, organism-specific biosystem (from REACTOME)
      ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
    • Alpha 6 Beta 4 signaling pathway, organism-specific biosystem (from WikiPathways)
      Alpha 6 Beta 4 signaling pathway, organism-specific biosystemThe integrin alpha6beta4 was discovered in the late 1980s by two different groups and was called either alphaEbeta4 or Ic-Ic binding protein (Ic-IcBP) (1,2). The alpha6beta4 integrin is a component o...
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Angiogenesis, organism-specific biosystem (from WikiPathways)
      Angiogenesis, organism-specific biosystemThis pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, ...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
      Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
      Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Corticotropin-releasing hormone signaling pathway, organism-specific biosystem (from WikiPathways)
      Corticotropin-releasing hormone signaling pathway, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • DAP12 interactions, organism-specific biosystem (from REACTOME)
      DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
    • DAP12 signaling, organism-specific biosystem (from REACTOME)
      DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
    • DCC mediated attractive signaling, organism-specific biosystem (from REACTOME)
      DCC mediated attractive signaling, organism-specific biosystemThe DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosi...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
      EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
    • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
      EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
    • EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
      EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
    • Endocrine resistance, organism-specific biosystem (from KEGG)
      Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endocrine resistance, conserved biosystem (from KEGG)
      Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • ErbB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      ErbB Signaling Pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
      FCERI mediated MAPK activation, organism-specific biosystemFormation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as th...
    • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
      Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Frs2-mediated activation, organism-specific biosystem (from REACTOME)
      Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
    • GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      GRB2 events in EGFR signaling, organism-specific biosystemAutophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through i...
    • GRB2:SOS provides linkage to MAPK signaling for Integrins, organism-specific biosystem (from REACTOME)
      GRB2:SOS provides linkage to MAPK signaling for Integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting Grb2 to the FADK1/SRC activation complex.
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
      IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
    • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
      IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
    • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
      IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
      Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
    • Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
      Integrin alphaIIb beta3 signaling, organism-specific biosystemAt the sites of vascular injury bioactive molecules such as thrombin, ADP, collagen, fibrinogen and thrombospondin are generated, secreted or exposed. These stimuli activate platelets, converting the...
    • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
      Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
      LPA receptor mediated events, organism-specific biosystem
      LPA receptor mediated events
    • Leptin signaling pathway, organism-specific biosystem (from WikiPathways)
      Leptin signaling pathway, organism-specific biosystemLeptin is a peptide hormone mainly synthesised and secreted from adipocytes. It is also expressed in other tissues including placenta, stomach and skeletal muscle. Leptin mediates its effects by bind...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
      MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
    • MET activates PTK2 signaling, organism-specific biosystem (from REACTOME)
      MET activates PTK2 signaling, organism-specific biosystemMET receptor activates the focal adhesion kinase PTK2 (FAK1) in a process that depends on the simultaneous interaction of PTK2 with integrins and with MET. SRC is needed for PTK2 to become fully acti...
    • MET promotes cell motility, organism-specific biosystem (from REACTOME)
      MET promotes cell motility, organism-specific biosystemDirect and indirect interactions of MET with integrins, focal adhesion kinase PTK2 (FAK1), tensin-4 (TNS4) and GTPases RAP1 and RAC1, induce morphological changes that promote cell motility and play ...
    • MFAP5-mediated ovarian cancer cell motility and invasiveness, organism-specific biosystem (from WikiPathways)
      MFAP5-mediated ovarian cancer cell motility and invasiveness, organism-specific biosystemA graphical summary of the molecular signalling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.
    • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
      NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Nanoparticle-mediated activation of receptor signaling, organism-specific biosystem (from WikiPathways)
      Nanoparticle-mediated activation of receptor signaling, organism-specific biosystemNanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as pro...
    • Netrin mediated repulsion signals, organism-specific biosystem (from REACTOME)
      Netrin mediated repulsion signals, organism-specific biosystemUnc5 netrin receptors mediate repellent responses to netrin. Four Unc5 members have been found in humans: Unc5A, B, C and D. Different studies have suggested that long-range repulsion to netrin requi...
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
    • Overview of nanoparticle effects, organism-specific biosystem (from WikiPathways)
      Overview of nanoparticle effects, organism-specific biosystemThis pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle specific effect known, there is a cascade of effects trigg...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
      Platelet Aggregation (Plug Formation), organism-specific biosystemThe tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment o...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
    • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
      Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
      RAF/MAP kinase cascade, organism-specific biosystemThe RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Bin...
    • RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
    • RET signaling, organism-specific biosystem (from REACTOME)
      RET signaling, organism-specific biosystemThe RET proto-oncogene encodes a receptor tyrosine kinase expressed primarily in urogenital precursor cells, spermatogonocytes, dopaminergic neurons, motor neurons and neural crest progenitors and de...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemWASP and WAVE proteins belong to the Wiskott-Aldrich Syndrome protein family, with recessive mutations in the founding member WASP being responsible for the X-linked recessive immunodeficieny known a...
    • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
      Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
      SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
      SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
      Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
    • Signaling by MET, organism-specific biosystem (from REACTOME)
      Signaling by MET, organism-specific biosystemMET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
      Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
    • Signalling to RAS, organism-specific biosystem (from REACTOME)
      Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    • p130Cas linkage to MAPK signaling for integrins, organism-specific biosystem (from REACTOME)
      p130Cas linkage to MAPK signaling for integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting p130cas and Crk to the FAK/Src activation complex.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    JUN kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    central nervous system neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    netrin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear migration IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    placenta development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of epithelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of focal adhesion assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of focal adhesion assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of substrate adhesion-dependent cell spreading IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    focal adhesion kinase 1
    Names
    FADK 1
    FAK-related non-kinase polypeptide
    PTK2 protein tyrosine kinase 2
    focal adhesion kinase isoform FAK-Del33
    focal adhesion kinase-related nonkinase
    protein phosphatase 1 regulatory subunit 71
    NP_001186578.1
    NP_001303271.1
    NP_001339623.1
    NP_001339624.1
    NP_001339625.1
    NP_001339626.1
    NP_001339627.1
    NP_001339628.1
    NP_001339629.1
    NP_001339630.1
    NP_001339631.1
    NP_001339632.1
    NP_001339633.1
    NP_001339634.1
    NP_001339635.1
    NP_001339636.1
    NP_001339637.1
    NP_001339638.1
    NP_001339639.1
    NP_001339640.1
    NP_001339641.1
    NP_001339642.1
    NP_001339643.1
    NP_001339644.1
    NP_001339645.1
    NP_001339646.1
    NP_001339647.1
    NP_001339648.1
    NP_001339649.1
    NP_001339650.1
    NP_001339651.1
    NP_001339652.1
    NP_001339653.1
    NP_001339654.1
    NP_001339655.1
    NP_001339656.1
    NP_001339657.1
    NP_001339658.1
    NP_001339659.1
    NP_001339660.1
    NP_001339661.1
    NP_001339662.1
    NP_001339663.1
    NP_001339664.1
    NP_001339665.1
    NP_001339666.1
    NP_001339667.1
    NP_001339668.1
    NP_001339669.1
    NP_001339670.1
    NP_001339671.1
    NP_001339672.1
    NP_001339673.1
    NP_001339674.1
    NP_001339675.1
    NP_001339676.1
    NP_001339677.1
    NP_001339678.1
    NP_001339679.1
    NP_001339680.1
    NP_001339681.1
    NP_005598.3
    NP_722560.1
    XP_016869142.1
    XP_016869143.1
    XP_016869145.1
    XP_016869146.1
    XP_016869153.1
    XP_016869155.1
    XP_016869158.1
    XP_016869173.1
    XP_016869177.1
    XP_024302967.1
    XP_024302968.1
    XP_024302969.1
    XP_024302970.1
    XP_024302971.1
    XP_024302972.1
    XP_024302973.1
    XP_024302974.1
    XP_024302975.1
    XP_024302976.1
    XP_024302977.1
    XP_024302978.1
    XP_024302979.1
    XP_024302980.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029467.2 RefSeqGene

      Range
      5001..347932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199649.2NP_001186578.1  focal adhesion kinase 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, and contains two additional in-frame segments near the 3' end of the coding sequence, compared to variant 2. The resulting isoform (c) is shorter at the N-terminus and contains two additional segments in the C-terminus compared to isoform b.
      Source sequence(s)
      AB209083, AC067931, AK304356, AL832961, BF434494, DA236314, DA994616
      Consensus CDS
      CCDS56557.1
      UniProtKB/Swiss-Prot
      Q05397
      UniProtKB/TrEMBL
      Q59GM6, Q658W2
      Related
      ENSP00000341189.3, ENST00000340930.7
      Conserved Domains (6) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9291058
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:422676
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001316342.2NP_001303271.1  focal adhesion kinase 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons and contains two other alternate in-frame exons compared to variant 2. The resulting isoform (d) differs in the 5' UTR, has a shorter and distinct N-terminus, and contains two alternative segments compared to isoform b. Variants 4 and 7 both encode the same isoform (d).
      Source sequence(s)
      AB209071, AC067931, BF434494, BY800117
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819948
      Focal_AT; Focal adhesion targeting region
    3. NM_001352694.2NP_001339623.1  focal adhesion kinase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 1, encodes isoform a.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      Related
      ENSP00000429474.1, ENST00000521059.5
      Conserved Domains (4) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region
    4. NM_001352695.2NP_001339624.1  focal adhesion kinase 1 isoform vv

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:449718
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9291058
      Focal_AT; Focal adhesion targeting region
    5. NM_001352696.2NP_001339625.1  focal adhesion kinase 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 4, encodes isoform d.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819948
      Focal_AT; Focal adhesion targeting region
    6. NM_001352697.2NP_001339626.1  focal adhesion kinase 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:500769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80302
      B41; Band 4.1 homologues
      cd13190
      Location:298408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9801109
      Focal_AT; Focal adhesion targeting region
    7. NM_001352698.2NP_001339627.1  focal adhesion kinase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:469738
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49271
      B41; Band 4.1 homologues
      cd13190
      Location:267377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9731102
      Focal_AT; Focal adhesion targeting region
    8. NM_001352699.2NP_001339628.1  focal adhesion kinase 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 11-14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    9. NM_001352700.2NP_001339629.1  focal adhesion kinase 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 10 and 12-14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    10. NM_001352701.2NP_001339630.1  focal adhesion kinase 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 10, 11, 13, and 14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    11. NM_001352702.2NP_001339631.1  focal adhesion kinase 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 10-12 and 14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    12. NM_001352703.2NP_001339632.1  focal adhesion kinase 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 10-13, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9601089
      Focal_AT; Focal adhesion targeting region
    13. NM_001352704.2NP_001339633.1  focal adhesion kinase 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:449718
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9531082
      Focal_AT; Focal adhesion targeting region
    14. NM_001352705.2NP_001339634.1  focal adhesion kinase 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:441710
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49271
      B41; Band 4.1 homologues
      cd13190
      Location:267377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9451074
      Focal_AT; Focal adhesion targeting region
    15. NM_001352706.2NP_001339635.1  focal adhesion kinase 1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 18-21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
    16. NM_001352707.2NP_001339636.1  focal adhesion kinase 1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 17 and 19-21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
    17. NM_001352708.2NP_001339637.1  focal adhesion kinase 1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 17,18, 20, and 21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
    18. NM_001352709.2NP_001339638.1  focal adhesion kinase 1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 17-19 and 21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
    19. NM_001352710.2NP_001339639.1  focal adhesion kinase 1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 17-20, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321061
      Focal_AT; Focal adhesion targeting region
    20. NM_001352711.2NP_001339640.1  focal adhesion kinase 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:427696
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9311060
      Focal_AT; Focal adhesion targeting region
    21. NM_001352712.2NP_001339641.1  focal adhesion kinase 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:456725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9571086
      Focal_AT; Focal adhesion targeting region
    22. NM_001352713.2NP_001339642.1  focal adhesion kinase 1 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform m.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
    23. NM_001352714.2NP_001339643.1  focal adhesion kinase 1 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform m.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:422691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
    24. NM_001352715.2NP_001339644.1  focal adhesion kinase 1 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9251054
      Focal_AT; Focal adhesion targeting region
    25. NM_001352716.2NP_001339645.1  focal adhesion kinase 1 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:420689
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9241053
      Focal_AT; Focal adhesion targeting region
    26. NM_001352717.2NP_001339646.1  focal adhesion kinase 1 isoform p

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9221051
      Focal_AT; Focal adhesion targeting region
    27. NM_001352718.2NP_001339647.1  focal adhesion kinase 1 isoform q

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
    28. NM_001352719.2NP_001339648.1  focal adhesion kinase 1 isoform q

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
    29. NM_001352720.2NP_001339649.1  focal adhesion kinase 1 isoform q

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9191048
      Focal_AT; Focal adhesion targeting region
    30. NM_001352721.2NP_001339650.1  focal adhesion kinase 1 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 33 and 34, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111040
      Focal_AT; Focal adhesion targeting region
    31. NM_001352722.2NP_001339651.1  focal adhesion kinase 1 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 32 and 34, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111040
      Focal_AT; Focal adhesion targeting region
    32. NM_001352723.2NP_001339652.1  focal adhesion kinase 1 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variants 32 and 33, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111040
      Focal_AT; Focal adhesion targeting region
    33. NM_001352724.2NP_001339653.1  focal adhesion kinase 1 isoform s

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9321034
      Focal_AT; Focal adhesion targeting region
    34. NM_001352725.2NP_001339654.1  focal adhesion kinase 1 isoform t

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8981027
      Focal_AT; Focal adhesion targeting region
    35. NM_001352726.2NP_001339655.1  focal adhesion kinase 1 isoform u

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:392661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8961025
      Focal_AT; Focal adhesion targeting region
    36. NM_001352727.2NP_001339656.1  focal adhesion kinase 1 isoform v

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:428697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9111013
      Focal_AT; Focal adhesion targeting region
    37. NM_001352728.2NP_001339657.1  focal adhesion kinase 1 isoform w

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:379648
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8801009
      Focal_AT; Focal adhesion targeting region
    38. NM_001352729.2NP_001339658.1  focal adhesion kinase 1 isoform x

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:392661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8751004
      Focal_AT; Focal adhesion targeting region
    39. NM_001352730.2NP_001339659.1  focal adhesion kinase 1 isoform y

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:847976
      Focal_AT; Focal adhesion targeting region
    40. NM_001352731.2NP_001339660.1  focal adhesion kinase 1 isoform z

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:845974
      Focal_AT; Focal adhesion targeting region
    41. NM_001352732.2NP_001339661.1  focal adhesion kinase 1 isoform aa

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:844973
      Focal_AT; Focal adhesion targeting region
    42. NM_001352733.2NP_001339662.1  focal adhesion kinase 1 isoform bb

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:336605
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:840969
      Focal_AT; Focal adhesion targeting region
    43. NM_001352734.2NP_001339663.1  focal adhesion kinase 1 isoform cc

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:343612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:826955
      Focal_AT; Focal adhesion targeting region
    44. NM_001352735.2NP_001339664.1  focal adhesion kinase 1 isoform tt

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:322591
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9124
      B41; Band 4.1 homologues
      cd13190
      Location:120230
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:826955
      Focal_AT; Focal adhesion targeting region
    45. NM_001352736.2NP_001339665.1  focal adhesion kinase 1 isoform dd

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:320589
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16157
      B41; Band 4.1 homologues
      cd13190
      Location:153263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:824953
      Focal_AT; Focal adhesion targeting region
    46. NM_001352737.2NP_001339666.1  focal adhesion kinase 1 isoform ee

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:336605
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:837966
      Focal_AT; Focal adhesion targeting region
    47. NM_001352738.2NP_001339667.1  focal adhesion kinase 1 isoform ff

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:817946
      Focal_AT; Focal adhesion targeting region
    48. NM_001352739.2NP_001339668.1  focal adhesion kinase 1 isoform gg

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:309578
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:813942
      Focal_AT; Focal adhesion targeting region
    49. NM_001352740.2NP_001339669.1  focal adhesion kinase 1 isoform hh

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:308577
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:812941
      Focal_AT; Focal adhesion targeting region
    50. NM_001352741.2NP_001339670.1  focal adhesion kinase 1 isoform ii

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806935
      Focal_AT; Focal adhesion targeting region
    51. NM_001352742.2NP_001339671.1  focal adhesion kinase 1 isoform jj

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:294563
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9124
      B41; Band 4.1 homologues
      cd13190
      Location:120230
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:798927
      Focal_AT; Focal adhesion targeting region
    52. NM_001352743.2NP_001339672.1  focal adhesion kinase 1 isoform uu

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:315584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:798927
      Focal_AT; Focal adhesion targeting region
    53. NM_001352744.2NP_001339673.1  focal adhesion kinase 1 isoform kk

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:279548
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:783912
      Focal_AT; Focal adhesion targeting region
    54. NM_001352745.2NP_001339674.1  focal adhesion kinase 1 isoform ll

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Conserved Domains (4) summary
      cd05056
      Location:273542
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:777906
      Focal_AT; Focal adhesion targeting region
    55. NM_001352746.2NP_001339675.1  focal adhesion kinase 1 isoform mm

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000428492.1, ENST00000523539.5
      Conserved Domains (4) summary
      cd05056
      Location:258527
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9124
      B41; Band 4.1 homologues
      cd13190
      Location:120194
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:762891
      Focal_AT; Focal adhesion targeting region
    56. NM_001352747.2NP_001339676.1  focal adhesion kinase 1 isoform nn

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENSP00000429170.1, ENST00000519465.5
      Conserved Domains (2) summary
      pfam03623
      Location:445574
      Focal_AT; Focal adhesion targeting region
      cl21453
      Location:1210
      PKc_like; Protein Kinases, catalytic domain
    57. NM_001352748.2NP_001339677.1  focal adhesion kinase 1 isoform oo

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cl21453
      Location:428496
      PKc_like; Protein Kinases, catalytic domain
    58. NM_001352749.2NP_001339678.1  focal adhesion kinase 1 isoform pp

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:229358
      Focal_AT; Focal adhesion targeting region
    59. NM_001352750.2NP_001339679.1  focal adhesion kinase 1 isoform qq

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Consensus CDS
      CCDS87628.1
      Related
      ENSP00000403416.2, ENST00000430260.6
      Conserved Domains (1) summary
      pfam03623
      Location:226355
      Focal_AT; Focal adhesion targeting region
    60. NM_001352751.2NP_001339680.1  focal adhesion kinase 1 isoform rr

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:208337
      Focal_AT; Focal adhesion targeting region
    61. NM_001352752.2NP_001339681.1  focal adhesion kinase 1 isoform ss

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:205334
      Focal_AT; Focal adhesion targeting region
    62. NM_005607.5NP_005598.3  focal adhesion kinase 1 isoform b

      See identical proteins and their annotated locations for NP_005598.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AB209083, AC067931, AC100860, AL832961, BF434494, DA236314
      UniProtKB/TrEMBL
      Q59GM6, Q658W2
      Conserved Domains (6) summary
      cd05056
      Location:437706
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:58280
      B41; Band 4.1 homologues
      cd13190
      Location:276386
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:165270
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:9381067
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:444698
      Pkinase_Tyr; Protein tyrosine kinase
    63. NM_153831.4NP_722560.1  focal adhesion kinase 1 isoform a

      See identical proteins and their annotated locations for NP_722560.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1 and 5 both encode the same isoform (a).
      Source sequence(s)
      AB209083, AC067931, AL832961, BF434494, DA236314, L13616
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      Q05397
      UniProtKB/TrEMBL
      Q59GM6, Q658W2
      Related
      ENSP00000429911.1, ENST00000522684.5
      Conserved Domains (4) summary
      cd05056
      Location:415684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9161045
      Focal_AT; Focal adhesion targeting region

    RNA

    1. NR_148036.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
    2. NR_148037.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
    3. NR_148038.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENST00000519993.5
    4. NR_148039.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      140657900..141002079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447210.1XP_024302978.1  focal adhesion kinase 1 isoform X16

      Conserved Domains (4) summary
      cd05056
      Location:443712
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9261055
      Focal_AT; Focal adhesion targeting region
    2. XM_024447207.1XP_024302975.1  focal adhesion kinase 1 isoform X13

      Conserved Domains (4) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9491078
      Focal_AT; Focal adhesion targeting region
    3. XM_024447206.1XP_024302974.1  focal adhesion kinase 1 isoform X12

      Conserved Domains (4) summary
      cd05056
      Location:479748
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9621091
      Focal_AT; Focal adhesion targeting region
    4. XM_024447205.1XP_024302973.1  focal adhesion kinase 1 isoform X9

      Conserved Domains (4) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9671096
      Focal_AT; Focal adhesion targeting region
    5. XM_024447203.1XP_024302971.1  focal adhesion kinase 1 isoform X6

      Conserved Domains (4) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9731102
      Focal_AT; Focal adhesion targeting region
    6. XM_017013666.1XP_016869155.1  focal adhesion kinase 1 isoform X18

    7. XM_017013669.2XP_016869158.1  focal adhesion kinase 1 isoform X19

    8. XM_024447202.1XP_024302970.1  focal adhesion kinase 1 isoform X5

      Conserved Domains (4) summary
      cd05056
      Location:473742
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9741103
      Focal_AT; Focal adhesion targeting region
    9. XM_017013656.2XP_016869145.1  focal adhesion kinase 1 isoform X10

      Related
      ENSP00000429082.1, ENST00000517887.5
    10. XM_017013688.2XP_016869177.1  focal adhesion kinase 1 isoform X23

      Conserved Domains (4) summary
      cd05056
      Location:279548
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:783912
      Focal_AT; Focal adhesion targeting region
    11. XM_017013684.2XP_016869173.1  focal adhesion kinase 1 isoform X21

      Conserved Domains (4) summary
      cd05056
      Location:309578
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:813942
      Focal_AT; Focal adhesion targeting region
    12. XM_024447211.1XP_024302979.1  focal adhesion kinase 1 isoform X20

      Conserved Domains (4) summary
      cd05056
      Location:392661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:8961025
      Focal_AT; Focal adhesion targeting region
    13. XM_024447209.1XP_024302977.1  focal adhesion kinase 1 isoform X15

      Conserved Domains (4) summary
      cd05056
      Location:437706
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9411070
      Focal_AT; Focal adhesion targeting region
    14. XM_024447208.1XP_024302976.1  focal adhesion kinase 1 isoform X14

      Conserved Domains (4) summary
      cd05056
      Location:443712
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9471076
      Focal_AT; Focal adhesion targeting region
    15. XM_024447200.1XP_024302968.1  focal adhesion kinase 1 isoform X2

      Conserved Domains (4) summary
      cd05056
      Location:473742
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9771106
      Focal_AT; Focal adhesion targeting region
    16. XM_024447199.1XP_024302967.1  focal adhesion kinase 1 isoform X1

      Conserved Domains (4) summary
      cd05056
      Location:479748
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9831112
      Focal_AT; Focal adhesion targeting region
    17. XM_017013654.2XP_016869143.1  focal adhesion kinase 1 isoform X8

    18. XM_017013653.2XP_016869142.1  focal adhesion kinase 1 isoform X4

    19. XM_024447212.1XP_024302980.1  focal adhesion kinase 1 isoform X22

      Conserved Domains (4) summary
      cd05056
      Location:302571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9145
      B41; Band 4.1 homologues
      cd13190
      Location:141251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806935
      Focal_AT; Focal adhesion targeting region
    20. XM_017013664.2XP_016869153.1  focal adhesion kinase 1 isoform X17

      Conserved Domains (4) summary
      cd05056
      Location:421690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36258
      B41; Band 4.1 homologues
      cd13190
      Location:254364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9251054
      Focal_AT; Focal adhesion targeting region
    21. XM_024447204.1XP_024302972.1  focal adhesion kinase 1 isoform X7

      Conserved Domains (4) summary
      cd05056
      Location:466735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9701099
      Focal_AT; Focal adhesion targeting region
    22. XM_024447201.1XP_024302969.1  focal adhesion kinase 1 isoform X3

      Conserved Domains (4) summary
      cd05056
      Location:472741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87309
      B41; Band 4.1 homologues
      cd13190
      Location:305415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:9761105
      Focal_AT; Focal adhesion targeting region
    23. XM_017013657.2XP_016869146.1  focal adhesion kinase 1 isoform X11

      Related
      ENSP00000429129.1, ENST00000519419.5
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