U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PTGFRN prostaglandin F2 receptor inhibitor [ Homo sapiens (human) ]

    Gene ID: 5738, updated on 6-Nov-2022

    Summary

    Official Symbol
    PTGFRNprovided by HGNC
    Official Full Name
    prostaglandin F2 receptor inhibitorprovided by HGNC
    Primary source
    HGNC:HGNC:9601
    See related
    Ensembl:ENSG00000134247 MIM:601204; AllianceGenome:HGNC:9601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPRP; CD315; EWI-F; CD9P-1; SMAP-6
    Summary
    Predicted to be involved in myoblast fusion involved in skeletal muscle regeneration. Predicted to act upstream of or within lipid droplet organization. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart (RPKM 21.3), endometrium (RPKM 18.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTGFRN in Genome Data Viewer
    Location:
    1p13.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (116909916..116990353)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (116920364..117000790)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117452538..117532975)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12934 Neighboring gene uncharacterized LOC105378927 Neighboring gene RNA, 5S ribosomal pseudogene 55 Neighboring gene Sharpr-MPRA regulatory region 2959 Neighboring gene uncharacterized LOC124904386 Neighboring gene CD101 molecule Neighboring gene CD101 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of prostaglandin F2 receptor inhibitor (PTGFRN) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11001, KIAA1436

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid droplet organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myoblast fusion involved in skeletal muscle regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface HDA PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    prostaglandin F2 receptor negative regulator
    Names
    CD9 partner 1
    glu-Trp-Ile EWI motif-containing protein F
    prostaglandin F2-alpha receptor regulatory protein
    prostaglandin F2-alpha receptor-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020440.4NP_065173.2  prostaglandin F2 receptor negative regulator precursor

      See identical proteins and their annotated locations for NP_065173.2

      Status: VALIDATED

      Source sequence(s)
      AA045111, AB037857, AK074637, AL157904, DA572787
      Consensus CDS
      CCDS890.1
      UniProtKB/Swiss-Prot
      Q8N2K6, Q9P2B2
      Related
      ENSP00000376899.2, ENST00000393203.3
      Conserved Domains (3) summary
      smart00406
      Location:39121
      IGv; Immunoglobulin V-Type
      smart00410
      Location:30140
      IG_like; Immunoglobulin like
      cl11960
      Location:283376
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      116909916..116990353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001874.2XP_016857363.1  prostaglandin F2 receptor negative regulator isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      116920364..117000790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)