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    CORO1B coronin 1B [ Homo sapiens (human) ]

    Gene ID: 57175, updated on 7-Jul-2024

    Summary

    Official Symbol
    CORO1Bprovided by HGNC
    Official Full Name
    coronin 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:2253
    See related
    Ensembl:ENSG00000172725 MIM:609849; AllianceGenome:HGNC:2253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CORONIN-2
    Summary
    Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 38.7), spleen (RPKM 34.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CORO1B in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67435510..67443809, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67429626..67437925, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67202981..67211280, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67183887-67184722 Neighboring gene carnosine synthase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67195675-67196442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67196443-67197210 Neighboring gene ribosomal protein S6 kinase B2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67201247-67202008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67203533-67204294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67204572-67205104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205105-67205637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67205638-67206170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67206171-67206702 Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67209163-67210002 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67210843-67211682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5101 Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5103 Neighboring gene transmembrane protein 134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67236334-67236958

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp762I166

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Arp2/3 complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament branching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lamellipodium morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in ruffle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coronin-1B
    Names
    coronin, actin binding protein, 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018070.3NP_001018080.1  coronin-1B

      See identical proteins and their annotated locations for NP_001018080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AP003419, BC006449, DA061767
      Consensus CDS
      CCDS8164.1
      UniProtKB/Swiss-Prot
      B2RD45, Q9BR76
      Related
      ENSP00000377471.1, ENST00000393893.5
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:10485
      WD40_4; Type of WD40 repeat
    2. NM_020441.3NP_065174.1  coronin-1B

      See identical proteins and their annotated locations for NP_065174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AP003419, BC006449
      Consensus CDS
      CCDS8164.1
      UniProtKB/Swiss-Prot
      B2RD45, Q9BR76
      Related
      ENSP00000340211.5, ENST00000341356.10
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:10485
      WD40_4; Type of WD40 repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      67435510..67443809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      67429626..67437925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)