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    CD177 CD177 molecule [ Homo sapiens (human) ]

    Gene ID: 57126, updated on 13-Feb-2019

    Summary

    Official Symbol
    CD177provided by HGNC
    Official Full Name
    CD177 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:30072
    See related
    Ensembl:ENSG00000204936 MIM:162860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP
    Summary
    This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue See more
    Orthologs

    Genomic context

    See CD177 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (43353659..43366063)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43857825..43867480)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule pseudogene 4 Neighboring gene p53-responsive gene 1 Neighboring gene CD177 molecule pseudogene 1 Neighboring gene testis expressed 101 Neighboring gene RNA, 28S ribosomal pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Common Pathway of Fibrin Clot Formation, organism-specific biosystem (from REACTOME)
      Common Pathway of Fibrin Clot Formation, organism-specific biosystemThe common pathway consists of the cascade of activation events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the f...
    • Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME)
      Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystemThe formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion via plasma-membrane adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    neutrophil extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT neutrophil migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neutrophil degranulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of superoxide anion generation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CD177 antigen
    Names
    NB1 glycoprotein
    cell surface receptor
    human neutrophil alloantigen 2a
    polycythemia rubra vera protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020406.4NP_065139.2  CD177 antigen precursor

      See identical proteins and their annotated locations for NP_065139.2

      Status: REVIEWED

      Source sequence(s)
      AK225226, AY358932, BC029167, BU688145, CD514938, DA728784, DB323632
      Consensus CDS
      CCDS62700.1
      UniProtKB/Swiss-Prot
      Q8N6Q3
      UniProtKB/TrEMBL
      A0A087WVM2
      Related
      ENSP00000479536.1, ENST00000618265.4
      Conserved Domains (2) summary
      pfam00021
      Location:133203
      UPAR_LY6; u-PAR/Ly-6 domain
      cl10471
      Location:325394
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      43353659..43366063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027021.2XP_016882510.1  CD177 antigen isoform X1

    2. XM_017027022.2XP_016882511.1  CD177 antigen isoform X2

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