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    CYSLTR2 cysteinyl leukotriene receptor 2 [ Homo sapiens (human) ]

    Gene ID: 57105, updated on 13-May-2022

    Summary

    Official Symbol
    CYSLTR2provided by HGNC
    Official Full Name
    cysteinyl leukotriene receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:18274
    See related
    Ensembl:ENSG00000152207 MIM:605666; AllianceGenome:HGNC:18274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
    Summary
    The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CYSLTR2 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (48653929..48711226)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (47874204..47931486)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49228065..49285362)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1077 Neighboring gene uncharacterized LOC105370202 Neighboring gene long intergenic non-protein coding RNA 462 Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene uncharacterized LOC107984559

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteinyl leukotriene receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables leukotriene receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucagon stimulus TAS
    Traceable Author Statement
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cysteinyl leukotriene receptor 2
    Names
    G-protein coupled receptor GPCR21
    G-protein coupled receptor HG57
    cysteinyl leukotriene CysLT2 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051649.1 RefSeqGene

      Range
      5219..62516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001308465.3NP_001295394.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295394.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (I) represents the longest transcript. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141523
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001308467.3NP_001295396.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295396.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (II) differs in the 5' UTR compared to variant 1. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141524
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001308468.3NP_001295397.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (III) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141525
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001308469.3NP_001295398.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141526
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001308470.3NP_001295399.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141529
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. NM_001308471.3NP_001295400.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295400.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141530
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Related
      ENSP00000282018.3, ENST00000282018.4
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    7. NM_001308476.3NP_001295405.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (V) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141527
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Related
      ENSP00000508181.1, ENST00000682523.1
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. NM_001387012.1NP_001373941.1  cysteinyl leukotriene receptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. NM_001387013.1NP_001373942.1  cysteinyl leukotriene receptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    10. NM_001387014.1NP_001373943.1  cysteinyl leukotriene receptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    11. NM_020377.5NP_065110.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_065110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (VI) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AK291739, AL137118
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Related
      ENSP00000477930.1, ENST00000614739.4
      Conserved Domains (1) summary
      cd15157
      Location:39316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      48653929..48711226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      47874204..47931486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)