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    CYSLTR2 cysteinyl leukotriene receptor 2 [ Homo sapiens (human) ]

    Gene ID: 57105, updated on 8-Jul-2018
    Official Symbol
    CYSLTR2provided by HGNC
    Official Full Name
    cysteinyl leukotriene receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:18274
    See related
    Ensembl:ENSG00000152207 MIM:605666; Vega:OTTHUMG00000016906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
    Summary
    The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues See more
    Orthologs
    See CYSLTR2 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (48653711..48711226)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49227847..49283498)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370202 Neighboring gene long intergenic non-protein coding RNA 462 Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene uncharacterized LOC107984559

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
    NHGRI GWA Catalog
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Eicosanoid ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Eicosanoid ligand-binding receptors, organism-specific biosystemEicosanoids, derived from polyunsaturated 20-carbon fatty acids, are paracrine and autocrine regulators of inflammation, smooth muscle contraction, and blood coagulation. The actions of eicosanoids a...
    • Endothelins, organism-specific biosystem (from Pathway Interaction Database)
      Endothelins, organism-specific biosystem
      Endothelins
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Leukotriene receptors, organism-specific biosystem (from REACTOME)
      Leukotriene receptors, organism-specific biosystemLeukotriene receptors bind leukotriene ligands. There are four types of receptor in humans; two for leukotriene B4 and two for cysteinyl leukotrienes (Brink C et al, 2003).
    • Lung fibrosis, organism-specific biosystem (from WikiPathways)
      Lung fibrosis, organism-specific biosystemLung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis.
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteinyl leukotriene receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    galanin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukotriene receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    cysteinyl leukotriene receptor 2
    Names
    G-protein coupled receptor GPCR21
    G-protein coupled receptor HG57
    cysteinyl leukotriene CysLT2 receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051649.1 RefSeqGene

      Range
      5001..62516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001308465.2NP_001295394.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295394.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (I) represents the longest transcript. Variants I to VIII encode the same protein.
      Source sequence(s)
      AL137118, EF141523
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001308467.2NP_001295396.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295396.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (II) differs in the 5' UTR compared to variant 1. Variants I to VIII encode the same protein.
      Source sequence(s)
      AL137118, EF141524
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_001308468.2NP_001295397.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (III) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
      Source sequence(s)
      AL137118, EF141525
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. NM_001308469.2NP_001295398.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
      Source sequence(s)
      AL137118, EF141526
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    5. NM_001308470.2NP_001295399.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
      Source sequence(s)
      AL137118, EF141529
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    6. NM_001308471.2NP_001295400.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295400.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
      Source sequence(s)
      AL137118, EF141530
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Related
      ENSP00000282018.3, OTTHUMP00000018401, ENST00000282018.4, OTTHUMT00000044894
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    7. NM_001308476.2NP_001295405.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (V) differs in the 5' UTR compared to variant I. Variants I to VIII encode the same protein.
      Source sequence(s)
      AL137118, EF141527
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      A4ZKH2, Q5KU17
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    8. NM_020377.4NP_065110.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_065110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (VI) differs in the 5' UTR compared to variant I. All variants encode the same protein.
      Source sequence(s)
      AK291739, AL137118
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Related
      ENSP00000477930.1, OTTHUMP00000275132, ENST00000614739.4, OTTHUMT00000474853
      Conserved Domains (1) summary
      pfam00001
      Location:55305
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      48653711..48711226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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