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    DDX24 DEAD-box helicase 24 [ Homo sapiens (human) ]

    Gene ID: 57062, updated on 22-May-2018
    Official Symbol
    DDX24provided by HGNC
    Official Full Name
    DEAD-box helicase 24provided by HGNC
    Primary source
    HGNC:HGNC:13266
    See related
    Ensembl:ENSG00000089737 MIM:606181; Vega:OTTHUMG00000171301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 90.5), adrenal (RPKM 75.8) and 25 other tissues See more
    Orthologs
    See DDX24 in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (94050922..94081212, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94517268..94547558, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 197 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene interferon alpha inducible protein 27 like 1 Neighboring gene interferon alpha inducible protein 27

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (DDX24), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    rev Decreased viral RNA packaging as a result of DDX24-knockdown is observed only in the context of Rev/RRE-dependent but not CTE (constitutive transport element)-mediated nuclear export of viral RNA PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA binding HDA PubMed 
    RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    RNA secondary structure unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane HDA PubMed 
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    ATP-dependent RNA helicase DDX24
    Names
    DEAD (Asp-Glu-Ala-Asp) box helicase 24
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
    DEAD box protein 24
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24
    S. cerevisiae CHL1-like helicase
    NP_065147.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020414.3NP_065147.1  ATP-dependent RNA helicase DDX24

      See identical proteins and their annotated locations for NP_065147.1

      Status: REVIEWED

      Source sequence(s)
      AF214731
      Consensus CDS
      CCDS9918.1
      UniProtKB/Swiss-Prot
      Q9GZR7
      Related
      ENSP00000481495.1, OTTHUMP00000245764, ENST00000621632.4, OTTHUMT00000412861
      Conserved Domains (3) summary
      COG0513
      Location:191783
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:573681
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:194511
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      94050922..94081212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      1165484..1195774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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