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    PSG1 pregnancy specific beta-1-glycoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 5669, updated on 5-Aug-2018

    Summary

    Official Symbol
    PSG1provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 1provided by HGNC
    Primary source
    HGNC:HGNC:9514
    See related
    Ensembl:ENSG00000231924 MIM:176390; Vega:OTTHUMG00000151123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1
    Summary
    The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 224.3) See more

    Genomic context

    See PSG1 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (42866461..42879822, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43370613..43383921, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PSG8 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 10, pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 6 Neighboring gene pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90598, FLJ90654

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    pregnancy-specific beta-1-glycoprotein 1
    Names
    CD66 antigen-like family member F
    fetal liver non-specific cross-reactive antigen 1/2
    pregnancy-specific B-1 glycoprotein
    pregnancy-specific beta-1 glycoprotein C/D

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184825.1NP_001171754.1  pregnancy-specific beta-1-glycoprotein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001171754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC005238
      Consensus CDS
      CCDS54275.1
      UniProtKB/Swiss-Prot
      P11464
      Related
      ENSP00000413041.2, OTTHUMP00000199195, ENST00000436291.6, OTTHUMT00000321426
      Conserved Domains (3) summary
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    2. NM_001184826.1NP_001171755.1  pregnancy-specific beta-1-glycoprotein 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001171755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 4. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC005238
      Consensus CDS
      CCDS59392.1
      UniProtKB/Swiss-Prot
      P11464
      Related
      ENSP00000472610.1, OTTHUMP00000270622, ENST00000595356.5, OTTHUMT00000464557
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    3. NM_001297773.1NP_001284702.1  pregnancy-specific beta-1-glycoprotein 1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001284702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      M20879
      Consensus CDS
      CCDS74380.1
      UniProtKB/Swiss-Prot
      P11464
      Related
      ENSP00000308970.6, OTTHUMP00000199198, ENST00000312439.10, OTTHUMT00000321429
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    4. NM_001330524.1NP_001317453.1  pregnancy-specific beta-1-glycoprotein 1 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC005238, DA829309
      Consensus CDS
      CCDS82360.1
      UniProtKB/TrEMBL
      G5E9F7
      Related
      ENSP00000385386.3, ENST00000403380.7
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    5. NM_006905.2NP_008836.2  pregnancy-specific beta-1-glycoprotein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_008836.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses alternate splice sites in the 3' terminal exon, compared to variant 4. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 4.
      Source sequence(s)
      AC005238, BC022338
      Consensus CDS
      CCDS12612.1
      UniProtKB/Swiss-Prot
      P11464
      Related
      ENSP00000244296.2, OTTHUMP00000199196, ENST00000244296.6, OTTHUMT00000321427
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      42866461..42879822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259065.4XP_005259122.1  pregnancy-specific beta-1-glycoprotein 1 isoform X1

      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
    2. XM_011527125.2XP_011525427.1  pregnancy-specific beta-1-glycoprotein 1 isoform X2

      See identical proteins and their annotated locations for XP_011525427.1

      UniProtKB/TrEMBL
      O75238
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246320
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain
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