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    PKN1 protein kinase N1 [ Homo sapiens (human) ]

    Gene ID: 5585, updated on 2-Oct-2018

    Summary

    Official Symbol
    PKN1provided by HGNC
    Official Full Name
    protein kinase N1provided by HGNC
    Primary source
    HGNC:HGNC:9405
    See related
    Ensembl:ENSG00000123143 MIM:601032; Vega:OTTHUMG00000039611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
    Summary
    The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 39.4), fat (RPKM 30.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See PKN1 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (14433354..14471867)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14544166..14582679)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E5 Neighboring gene DExD-box helicase 39A Neighboring gene prostaglandin E receptor 1 Neighboring gene GIPC PDZ domain containing family member 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Application of HIV-1 Tat transmembrane transport peptide to cells induces PKN1 gene and slightly represses two genes, ZCD1 and BSG PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC46204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP-Rho binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rac GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    androgen receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone kinase activity (H3-T11 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear receptor transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear receptor transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    activation of JUN kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-T11 phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hyperosmotic response IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of nucleic acid-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of germinal center formation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal system process IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase N1
    Names
    protease-activated kinase 1
    protein kinase C-like 1
    protein kinase C-like PKN
    protein kinase C-related kinase 1
    protein kinase PKN-alpha
    serine-threonine kinase N
    serine/threonine protein kinase N
    NP_002732.3
    NP_998725.1
    XP_011526430.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002741.4NP_002732.3  serine/threonine-protein kinase N1 isoform 2

      See identical proteins and their annotated locations for NP_002732.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon at the 5' end compared to variant 1, which includes a part of the coding region. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC008569
      Consensus CDS
      CCDS42513.1
      UniProtKB/Swiss-Prot
      Q16512
      Related
      ENSP00000242783.6, OTTHUMP00000037582, ENST00000242783.10
      Conserved Domains (6) summary
      cd08687
      Location:389476
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:4698
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:121196
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd11636
      Location:205278
      HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      smart00220
      Location:615874
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05589
      Location:615939
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    2. NM_213560.2NP_998725.1  serine/threonine-protein kinase N1 isoform 1

      See identical proteins and their annotated locations for NP_998725.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC008569
      Consensus CDS
      CCDS42514.1
      UniProtKB/Swiss-Prot
      Q16512
      Related
      ENSP00000343325.4, OTTHUMP00000037583, ENST00000342216.8
      Conserved Domains (6) summary
      cd08687
      Location:395482
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:52104
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:127202
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd11636
      Location:211284
      HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      smart00220
      Location:621880
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05589
      Location:621945
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      14433354..14471867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528128.1XP_011526430.1  serine/threonine-protein kinase N1 isoform X1

      Conserved Domains (6) summary
      cd08687
      Location:401488
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:58110
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:133208
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd11636
      Location:217290
      HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      smart00220
      Location:627886
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05589
      Location:627951
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
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