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    CDCA8 cell division cycle associated 8 [ Homo sapiens (human) ]

    Gene ID: 55143, updated on 5-Mar-2024

    Summary

    Official Symbol
    CDCA8provided by HGNC
    Official Full Name
    cell division cycle associated 8provided by HGNC
    Primary source
    HGNC:HGNC:14629
    See related
    Ensembl:ENSG00000134690 MIM:609977; AllianceGenome:HGNC:14629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BOR; DasraB; MESRGP; BOREALIN
    Summary
    This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDCA8 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37692516..37709719)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37557243..37574423)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38158188..38175391)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1490 Neighboring gene R-spondin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38096333-38096846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38098855-38099382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38099911-38100438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38100439-38100965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38126219-38126852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38128815-38129348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38129349-38129881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38132271-38132990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38156929-38157439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38157440-38157949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38157950-38158460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38158461-38158969 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene MPRA-validated peak183 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191191-38191692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191693-38192192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192280-38192780 Neighboring gene EPH receptor A10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192781-38193281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38201025-38201524 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 677 Neighboring gene uncharacterized LOC105378650

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10468, FLJ12042

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IEA
    Inferred from Electronic Annotation
    more info
     
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chromosome passenger complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    borealin
    Names
    Dasra B
    cell division cycle-associated protein 8
    dasra-B
    hDasra-B
    pluripotent embryonic stem cell-related gene 3 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256875.2NP_001243804.1  borealin

      See identical proteins and their annotated locations for NP_001243804.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC001651, BC008079
      Consensus CDS
      CCDS424.1
      UniProtKB/Swiss-Prot
      D3DPT4, Q53HL2, Q53HN1, Q96AM3, Q9NVW5
      UniProtKB/TrEMBL
      A8K7A2
      Related
      ENSP00000362146.1, ENST00000373055.6
      Conserved Domains (2) summary
      pfam10444
      Location:2276
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:163275
      Borealin; Cell division cycle-associated protein 8
    2. NM_018101.4NP_060571.1  borealin

      See identical proteins and their annotated locations for NP_060571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY508815, BC008079
      Consensus CDS
      CCDS424.1
      UniProtKB/Swiss-Prot
      D3DPT4, Q53HL2, Q53HN1, Q96AM3, Q9NVW5
      UniProtKB/TrEMBL
      A8K7A2
      Related
      ENSP00000316121.2, ENST00000327331.2
      Conserved Domains (2) summary
      pfam10444
      Location:2276
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:163275
      Borealin; Cell division cycle-associated protein 8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      37692516..37709719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      37557243..37574423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)