Format

Send to:

Choose Destination
    • Showing Current items.

    SLC6A15 solute carrier family 6 member 15 [ Homo sapiens (human) ]

    Gene ID: 55117, updated on 7-Dec-2018

    Summary

    Official Symbol
    SLC6A15provided by HGNC
    Official Full Name
    solute carrier family 6 member 15provided by HGNC
    Primary source
    HGNC:HGNC:13621
    See related
    Ensembl:ENSG00000072041 MIM:607971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    V7-3; NTT73; SBAT1; hv7-3
    Summary
    This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
    Expression
    Biased expression in brain (RPKM 5.0), placenta (RPKM 1.2) and 3 other tissues See more
    Orthologs

    Genomic context

    See SLC6A15 in Genome Data Viewer
    Location:
    12q21.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (84859488..84912829, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (85253267..85306608, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 12 pseudogene Neighboring gene uncharacterized LOC105369875 Neighboring gene uncharacterized LOC102724680 Neighboring gene tetraspanin 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    NHGRI GWA Catalog
    The neuronal transporter gene SLC6A15 confers risk to major depression.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10316, MGC87066, DKFZp761I0921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    amino acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    neurotransmitter transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neurotransmitter:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    amino acid transport TAS
    Traceable Author Statement
    more info
     
    leucine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leucine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotransmitter transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sodium-dependent neutral amino acid transporter B(0)AT2
    Names
    homolog of rat orphan transporter v7-3
    orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
    orphan transporter v7-3
    sodium- and chloride-dependent neurotransmitter transporter NTT73
    sodium-coupled branched-chain amino-acid transporter 1
    sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7
    solute carrier family 6 (neurotransmitter transporter), member 15
    solute carrier family 6 (neutral amino acid transporter), member 15
    transporter v7-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146335.2NP_001139807.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform 3

      See identical proteins and their annotated locations for NP_001139807.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks the 5' coding exon, resulting in a downstream AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC018922, AF351619, AI368909, AK001178, AK294945, DA247242
      Consensus CDS
      CCDS53816.1
      UniProtKB/Swiss-Prot
      Q9H2J7
      UniProtKB/TrEMBL
      Q8IXG2, Q9NW50
      Related
      ENSP00000450145.1, ENST00000552192.5
      Conserved Domains (1) summary
      cl00456
      Location:1533
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_018057.6NP_060527.2  sodium-dependent neutral amino acid transporter B(0)AT2 isoform 2

      See identical proteins and their annotated locations for NP_060527.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC018922, AK022853, CF529868, DA247242
      Consensus CDS
      CCDS9027.1
      UniProtKB/Swiss-Prot
      Q9H2J7
      Related
      ENSP00000390706.2, ENST00000450363.3
      Conserved Domains (1) summary
      cl00456
      Location:61263
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. NM_182767.6NP_877499.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform 1

      See identical proteins and their annotated locations for NP_877499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC018922, AF265577, AI368909, DA247242
      Consensus CDS
      CCDS9026.1
      UniProtKB/Swiss-Prot
      Q9H2J7
      Related
      ENSP00000266682.5, ENST00000266682.9
      Conserved Domains (1) summary
      cd11522
      Location:61640
      SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      84859488..84912829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538525.3XP_011536827.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:61498
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Support Center