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    INTS11 integrator complex subunit 11 [ Homo sapiens (human) ]

    Gene ID: 54973, updated on 18-Nov-2018

    Summary

    Official Symbol
    INTS11provided by HGNC
    Official Full Name
    integrator complex subunit 11provided by HGNC
    Primary source
    HGNC:HGNC:26052
    See related
    Ensembl:ENSG00000127054 MIM:611354; Vega:OTTHUMG00000003330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RC68; INT11; RC-68; CPSF3L; CPSF73L
    Summary
    The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in testis (RPKM 35.0), endometrium (RPKM 21.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See INTS11 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1311585..1324687, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1246965..1260067, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene microRNA 6726 Neighboring gene small nucleolar RNA, C/D box 167 Neighboring gene pseudouridine synthase like 1 Neighboring gene microRNA 6727 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene taste 1 receptor member 3 Neighboring gene dishevelled segment polarity protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
      RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ13294, FLJ20542

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    snRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    snRNA transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    blood microparticle HDA PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrator complex subunit 11
    Names
    CPSF3-like protein
    cleavage and polyadenylation specific factor 3-like
    cleavage and polyadenylation-specific factor 3-like protein
    protein related to CPSF subunits of 68 kDa
    related to CPSF subunits 68 kDa
    NP_001243385.1
    NP_001243389.1
    NP_001243391.1
    NP_001243392.1
    NP_060341.2
    XP_011539949.1
    XP_011539950.1
    XP_011539952.1
    XP_016857046.1
    XP_016857047.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256456.1NP_001243385.1  integrator complex subunit 11 isoform 1

      See identical proteins and their annotated locations for NP_001243385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AA687684, AK056652, AK291387, AK297350, DC299237
      Consensus CDS
      CCDS57960.1
      UniProtKB/Swiss-Prot
      Q5TA45
      Related
      ENSP00000445001.1, ENST00000540437.5
      Conserved Domains (5) summary
      smart01027
      Location:251369
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:16450
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:382422
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:16210
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
      cl02570
      Location:414486
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    2. NM_001256460.1NP_001243389.1  integrator complex subunit 11 isoform 3

      See identical proteins and their annotated locations for NP_001243389.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AA687684, AK291387, AK297350, DC295791, DC299237
      Consensus CDS
      CCDS57959.1
      UniProtKB/Swiss-Prot
      Q5TA45
      Related
      ENSP00000444672.1, ENST00000545578.5
      Conserved Domains (5) summary
      smart01027
      Location:216334
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:1415
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:347387
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:1175
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
      cl02570
      Location:379451
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    3. NM_001256462.1NP_001243391.1  integrator complex subunit 11 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several exons which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AA687684, AK058018, AK291387, DC299237
      Consensus CDS
      CCDS72678.1
      UniProtKB/Swiss-Prot
      Q5TA45
      UniProtKB/TrEMBL
      A0A087WYI0
      Related
      ENSP00000481821.1, ENST00000620829.4
      Conserved Domains (5) summary
      smart01027
      Location:147265
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:48346
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:278318
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cl02570
      Location:310382
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl23716
      Location:46106
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    4. NM_001256463.1NP_001243392.1  integrator complex subunit 11 isoform 5

      See identical proteins and their annotated locations for NP_001243392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AA687684, AK021939, AK058018, DC299237
      Consensus CDS
      CCDS57961.1
      UniProtKB/Swiss-Prot
      Q5TA45
      UniProtKB/TrEMBL
      A0A024R073
      Related
      ENSP00000404886.1, OTTHUMP00000003391, ENST00000419704.5, OTTHUMT00000009368
      Conserved Domains (5) summary
      smart01027
      Location:144262
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:4343
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:275315
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cl02570
      Location:307379
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl23716
      Location:6103
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    5. NM_017871.5NP_060341.2  integrator complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_060341.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the coding region which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AA687684, AK023356, AL136813, DC299237, DC299993
      Consensus CDS
      CCDS21.1
      UniProtKB/Swiss-Prot
      Q5TA45
      UniProtKB/TrEMBL
      A0A024R0F2
      Related
      ENSP00000413493.1, OTTHUMP00000003390, ENST00000435064.5, OTTHUMT00000009360
      Conserved Domains (5) summary
      smart01027
      Location:245363
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:4444
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:376416
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:6204
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
      cl02570
      Location:408480
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      1311585..1324687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541650.2XP_011539952.1  integrator complex subunit 11 isoform X3

      See identical proteins and their annotated locations for XP_011539952.1

      Conserved Domains (5) summary
      smart01027
      Location:121239
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:2320
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:252292
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cl02570
      Location:284356
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl23716
      Location:180
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    2. XM_011541647.1XP_011539949.1  integrator complex subunit 11 isoform X1

      Conserved Domains (5) summary
      smart01027
      Location:305423
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:70504
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:436476
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:70264
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
      cl02570
      Location:468540
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    3. XM_011541648.1XP_011539950.1  integrator complex subunit 11 isoform X2

      Conserved Domains (5) summary
      smart01027
      Location:267385
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:32466
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:398438
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:32226
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
      cl02570
      Location:430502
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    4. XM_017001557.1XP_016857046.1  integrator complex subunit 11 isoform X3

      Conserved Domains (5) summary
      smart01027
      Location:121239
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:2320
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:252292
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cl02570
      Location:284356
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl23716
      Location:180
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    5. XM_017001558.1XP_016857047.1  integrator complex subunit 11 isoform X3

      Conserved Domains (5) summary
      smart01027
      Location:121239
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:2320
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:252292
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cl02570
      Location:284356
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl23716
      Location:180
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032179.1: Suppressed sequence

      Description
      NM_032179.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center