ATP7B ATPase copper transporting beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATP7Bprovided by HGNC
Official Full Name: ATPase copper transporting betaprovided by HGNC
Primary source: HGNC:HGNC:870
See related: Ensembl:ENSG00000123191 MIM:606882; AllianceGenome:HGNC:870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WD; PWD; WC1; WND
Summary: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019]
Expression: Broad expression in testis (RPKM 5.6), duodenum (RPKM 4.2) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q14.3

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (51932669..52012132, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (51147339..51226266, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (52506805..52585586, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of Wilson disease mutations in copper binding domain of ATP7B gene.
Title: Analysis of Wilson disease mutations in copper binding domain of ATP7B gene.
Analysis of mutations spectrum in the ATP7B gene in patients with Wilson disease using massively parallel sequencing.", trans "capital A, Cyrillicsmall en, Cyrillicsmall a, Cyrillicsmall el, Cyrillicsmall i, Cyrillicsmall ze, Cyrillic small es, Cyrillicsmall pe, Cyrillicsmall ie, Cyrillicsmall ka, Cyrillicsmall te, Cyrillicsmall er, Cyrillicsmall a, Cyrillic small em, Cyrillicsmall u, Cyrillicsmall te, Cyrillicsmall a,...
Title: Analysis of mutations spectrum in the ATP7B gene in patients with Wilson disease using massively parallel sequencing.
[Phenotypes and ATP7B gene variants in 316 children with Wilson disease].
Title: [Phenotypes and ATP7B gene variants in 316 children with Wilson disease].
Correlation of ATP7B gene mutations with clinical phenotype and radiological features in Indian Wilson disease patients.
Title: Correlation of ATP7B gene mutations with clinical phenotype and radiological features in Indian Wilson disease patients.
Molecular analysis of 53 Chinese families with Wilson's disease: Six novel mutations identified.
Title: Molecular analysis of 53 Chinese families with Wilson's disease: Six novel mutations identified.
TFEB Regulates ATP7B Expression to Promote Platinum Chemoresistance in Human Ovarian Cancer Cells.
Title: TFEB Regulates ATP7B Expression to Promote Platinum Chemoresistance in Human Ovarian Cancer Cells.
Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease.
Title: Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease.
Direct Interaction of ATP7B and LC3B Proteins Suggests a Cooperative Role of Copper Transportation and Autophagy.
Title: Direct Interaction of ATP7B and LC3B Proteins Suggests a Cooperative Role of Copper Transportation and Autophagy.
Investigation of the Wilson gene ATP7B transcriptional start site and the effect of core promoter alterations.
Title: Investigation of the Wilson gene ATP7B transcriptional start site and the effect of core promoter alterations.
Copper Imbalance in Alzheimer's Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating ATP7B Gene Variants.
Title: Copper Imbalance in Alzheimer's Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating <i>ATP7B</i> Gene Variants.

Submit: New GeneRIF Correction See all GeneRIFs (275)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Wilson disease MedGen: C0019202 OMIM: 277900 GeneReviews: Wilson Disease	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S1101 (e-PCR)
- UniSTS:34061

SHGC-79066 (e-PCR)
- UniSTS:100913

GDB:532997 (e-PCR)
- UniSTS:157560

GDB:533003 (e-PCR)
- UniSTS:157561

GDB:533006 (e-PCR)
- UniSTS:157562

SHGC-146451 (e-PCR)
- UniSTS:175226

GDB:533013 (e-PCR)
- UniSTS:157564

GDB:533021 (e-PCR)
- UniSTS:157566

GDB:533046 (e-PCR)
- UniSTS:157567

GDB:533050 (e-PCR)
- UniSTS:157568

GDB:533057 (e-PCR)
- UniSTS:157569

GDB:542970 (e-PCR)
- UniSTS:157574

GDB:542978 (e-PCR)
- UniSTS:157576

RH98917 (e-PCR)
- UniSTS:83850

GDB:542982 (e-PCR)
- UniSTS:157578

GDB:547725 (e-PCR)
- UniSTS:157590

GDB:547728 (e-PCR)
- UniSTS:157591

GDB:547732 (e-PCR)
- UniSTS:157592

GDB:547739 (e-PCR)
- UniSTS:157593

GDB:547748 (e-PCR)
- UniSTS:157594

GDB:547753 (e-PCR)
- UniSTS:157595

GDB:547758 (e-PCR)
- UniSTS:157596

GDB:547771 (e-PCR)
- UniSTS:157597

SHGC-8883 (e-PCR)
- UniSTS:3271

RH123821 (e-PCR)
- UniSTS:136142

SHGC-147086 (e-PCR)
- UniSTS:175601

RH45092 (e-PCR)
- UniSTS:51187

Homology

Homologs of the ATP7B gene: The ATP7B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 313 organisms have orthologs with human gene ATP7B
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type divalent copper transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables P-type divalent copper transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables P-type divalent copper transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables P-type divalent copper transporter activity	TAS Traceable Author Statement more info	PubMed
enables P-type monovalent copper transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular copper ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular copper ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in cellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in copper ion export	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in copper ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in copper ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in copper ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
involved_in ion transmembrane transport	TAS Traceable Author Statement more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by copper ion transfer	IEA Inferred from Electronic Annotation more info
involved_in response to copper ion	IDA Inferred from Direct Assay more info	PubMed
involved_in sequestering of calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in Golgi membrane	TAS Traceable Author Statement more info
colocalizes_with basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in integral component of plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
colocalizes_with perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: copper-transporting ATPase 2

Names: ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; Wilson disease-associated protein; copper pump 2; copper-transporting protein ATP7B

NP_000044.2

EC 7.2.2.8

NP_001005918.1

EC 7.2.2.8

NP_001230111.1

EC 7.2.2.8

NP_001317507.1

EC 7.2.2.8

NP_001317508.1

EC 7.2.2.8

XP_005266480.1

EC 7.2.2.8

XP_005266481.1

EC 7.2.2.8

XP_005266487.1

EC 7.2.2.8

XP_005266488.1

EC 7.2.2.8

XP_006719900.1

EC 7.2.2.8

XP_011533419.1

EC 7.2.2.8

XP_016876116.1

EC 7.2.2.8

XP_047286341.1

EC 7.2.2.8

XP_047286342.1

EC 7.2.2.8

XP_047286343.1

EC 7.2.2.8

XP_047286344.1

EC 7.2.2.8

XP_047286345.1

EC 7.2.2.8

XP_047286346.1

EC 7.2.2.8

XP_047286347.1

EC 7.2.2.8

XP_047286348.1

EC 7.2.2.8

XP_047286349.1

EC 7.2.2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008806.1 RefSeqGene

Range

5045..83826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000053.4 → NP_000044.2 copper-transporting ATPase 2 isoform a

See identical proteins and their annotated locations for NP_000044.2

Status: REVIEWED

Source sequence(s)

AL162377, BC143976, BU682287, DA125470, U11700

Consensus CDS

CCDS41892.1

UniProtKB/Swiss-Prot

P35670, Q5T7X7

UniProtKB/TrEMBL

A0A024RDX3, B7ZLR4

Related

ENSP00000242839.5, ENST00000242839.10

Conserved Domains (4) summary

COG2217
Location:566 → 1355

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1206 → 1309

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:363 → 425

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:769 → 1016

E1-E2_ATPase; E1-E2 ATPase
NM_001005918.3 → NP_001005918.1 copper-transporting ATPase 2 isoform b

See identical proteins and their annotated locations for NP_001005918.1

Status: REVIEWED

Source sequence(s)

AL162377, BC143976, BU682287, DA125470

Consensus CDS

CCDS45049.1

UniProtKB/TrEMBL

B7ZLR4

Related

ENSP00000342559.5, ENST00000344297.9

Conserved Domains (4) summary

COG2217
Location:360 → 1148

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:999 → 1102

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:363 → 425

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:621 → 809

E1-E2_ATPase; E1-E2 ATPase
NM_001243182.2 → NP_001230111.1 copper-transporting ATPase 2 isoform c

Status: REVIEWED

Source sequence(s)

AL162377, BC143976, BU682287, DA125470, DQ015922

Consensus CDS

CCDS58293.1

UniProtKB/Swiss-Prot

P35670

UniProtKB/TrEMBL

B7ZLR4

Related

ENSP00000383217.3, ENST00000400366.6

Conserved Domains (4) summary

COG2217
Location:455 → 1244

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1095 → 1198

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:146 → 209

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:658 → 905

E1-E2_ATPase; E1-E2 ATPase
NM_001330578.2 → NP_001317507.1 copper-transporting ATPase 2 isoform d

Status: REVIEWED

Source sequence(s)

AL162377, BC143975, BC143976, BU682287, DA125470, U11700

Consensus CDS

CCDS81768.1

UniProtKB/Swiss-Prot

P35670

UniProtKB/TrEMBL

B7ZLR3, B7ZLR4, E7ET55

Related

ENSP00000501168.1, ENST00000673772.1

Conserved Domains (4) summary

COG2217
Location:566 → 1277

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1128 → 1231

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:363 → 425

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:694 → 938

E1-E2_ATPase; E1-E2 ATPase
NM_001330579.2 → NP_001317508.1 copper-transporting ATPase 2 isoform e

Status: REVIEWED

Source sequence(s)

AL162377, BC143976, BU682287, DA125470, U11700

UniProtKB/Swiss-Prot

P35670

UniProtKB/TrEMBL

B7ZLR4

Related

ENSP00000416738.3, ENST00000448424.7

Conserved Domains (4) summary

COG4087
Location:1122 → 1225

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:363 → 425

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

TIGR01511
Location:626 → 1271

ATPase-IB1_Cu; copper-(or silver)-translocating P-type ATPase

pfam00122
Location:685 → 932

E1-E2_ATPase; E1-E2 ATPase
NM_001406511.1 → NP_001393440.1 copper-transporting ATPase 2 isoform a

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377

UniProtKB/Swiss-Prot

Q5T7X7
NM_001406512.1 → NP_001393441.1 copper-transporting ATPase 2 isoform a

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377

UniProtKB/Swiss-Prot

Q5T7X7
NM_001406513.1 → NP_001393442.1 copper-transporting ATPase 2 isoform f

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406514.1 → NP_001393443.1 copper-transporting ATPase 2 isoform g

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406515.1 → NP_001393444.1 copper-transporting ATPase 2 isoform h

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406516.1 → NP_001393445.1 copper-transporting ATPase 2 isoform h

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406517.1 → NP_001393446.1 copper-transporting ATPase 2 isoform i

Status: REVIEWED

Source sequence(s)

AL138821, AL162377
NM_001406518.1 → NP_001393447.1 copper-transporting ATPase 2 isoform i

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406519.1 → NP_001393448.1 copper-transporting ATPase 2 isoform j

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406520.1 → NP_001393449.1 copper-transporting ATPase 2 isoform k

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406521.1 → NP_001393450.1 copper-transporting ATPase 2 isoform k

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406522.1 → NP_001393451.1 copper-transporting ATPase 2 isoform k

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406523.1 → NP_001393452.1 copper-transporting ATPase 2 isoform m

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406524.1 → NP_001393453.1 copper-transporting ATPase 2 isoform l

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406525.1 → NP_001393454.1 copper-transporting ATPase 2 isoform n

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406526.1 → NP_001393455.1 copper-transporting ATPase 2 isoform o

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406527.1 → NP_001393456.1 copper-transporting ATPase 2 isoform d

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406528.1 → NP_001393457.1 copper-transporting ATPase 2 isoform d

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406530.1 → NP_001393459.1 copper-transporting ATPase 2 isoform p

Status: REVIEWED

Source sequence(s)

AL138821, AL162377
NM_001406531.1 → NP_001393460.1 copper-transporting ATPase 2 isoform e

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406532.1 → NP_001393461.1 copper-transporting ATPase 2 isoform e

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406534.1 → NP_001393463.1 copper-transporting ATPase 2 isoform q

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406535.1 → NP_001393464.1 copper-transporting ATPase 2 isoform r

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406536.1 → NP_001393465.1 copper-transporting ATPase 2 isoform s

Status: REVIEWED

Source sequence(s)

AL138821, AL162377
NM_001406537.1 → NP_001393466.1 copper-transporting ATPase 2 isoform t

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406538.1 → NP_001393467.1 copper-transporting ATPase 2 isoform u

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406539.1 → NP_001393468.1 copper-transporting ATPase 2 isoform v

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406540.1 → NP_001393469.1 copper-transporting ATPase 2 isoform w

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406541.1 → NP_001393470.1 copper-transporting ATPase 2 isoform x

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406542.1 → NP_001393471.1 copper-transporting ATPase 2 isoform x

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406543.1 → NP_001393472.1 copper-transporting ATPase 2 isoform y

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406544.1 → NP_001393473.1 copper-transporting ATPase 2 isoform z

Status: REVIEWED

Source sequence(s)

AL138821, AL162377
NM_001406545.1 → NP_001393474.1 copper-transporting ATPase 2 isoform aa

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406546.1 → NP_001393475.1 copper-transporting ATPase 2 isoform bb

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406547.1 → NP_001393476.1 copper-transporting ATPase 2 isoform cc

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377
NM_001406548.1 → NP_001393477.1 copper-transporting ATPase 2 isoform dd

Status: REVIEWED

Source sequence(s)

AL138821, AL139082, AL162377

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p14 Primary Assembly

Range

51932669..52012132 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047430389.1 → XP_047286345.1 copper-transporting ATPase 2 isoform X8
XM_047430388.1 → XP_047286344.1 copper-transporting ATPase 2 isoform X7
XM_047430387.1 → XP_047286343.1 copper-transporting ATPase 2 isoform X6
XM_005266430.5 → XP_005266487.1 copper-transporting ATPase 2 isoform X1

UniProtKB/Swiss-Prot

P35670

UniProtKB/TrEMBL

A0A024RDX3

Conserved Domains (4) summary

COG2217
Location:566 → 1355

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1206 → 1309

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:363 → 425

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:769 → 1016

E1-E2_ATPase; E1-E2 ATPase
XM_047430385.1 → XP_047286341.1 copper-transporting ATPase 2 isoform X4
XM_047430386.1 → XP_047286342.1 copper-transporting ATPase 2 isoform X5
XM_011535117.4 → XP_011533419.1 copper-transporting ATPase 2 isoform X3

See identical proteins and their annotated locations for XP_011533419.1

Conserved Domains (4) summary

COG2217
Location:534 → 1323

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1174 → 1277

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:331 → 393

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:737 → 984

E1-E2_ATPase; E1-E2 ATPase
XM_005266431.5 → XP_005266488.1 copper-transporting ATPase 2 isoform X2

Conserved Domains (4) summary

COG2217
Location:554 → 1343

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1194 → 1297

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:351 → 413

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:757 → 1004

E1-E2_ATPase; E1-E2 ATPase
XM_006719837.4 → XP_006719900.1 copper-transporting ATPase 2 isoform X3

Conserved Domains (4) summary

COG2217
Location:534 → 1323

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1174 → 1277

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:331 → 393

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:737 → 984

E1-E2_ATPase; E1-E2 ATPase
XM_017020627.2 → XP_016876116.1 copper-transporting ATPase 2 isoform X3

Conserved Domains (4) summary

COG2217
Location:534 → 1323

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1174 → 1277

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:331 → 393

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:737 → 984

E1-E2_ATPase; E1-E2 ATPase
XM_005266424.5 → XP_005266481.1 copper-transporting ATPase 2 isoform X3

See identical proteins and their annotated locations for XP_005266481.1

Conserved Domains (4) summary

COG2217
Location:534 → 1323

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1174 → 1277

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:331 → 393

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:737 → 984

E1-E2_ATPase; E1-E2 ATPase
XM_005266423.3 → XP_005266480.1 copper-transporting ATPase 2 isoform X3

See identical proteins and their annotated locations for XP_005266480.1

Conserved Domains (4) summary

COG2217
Location:534 → 1323

ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]

COG4087
Location:1174 → 1277

COG4087; Soluble P-type ATPase [General function prediction only]

cd00371
Location:331 → 393

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00122
Location:737 → 984

E1-E2_ATPase; E1-E2 ATPase
XM_047430390.1 → XP_047286346.1 copper-transporting ATPase 2 isoform X9
XM_047430391.1 → XP_047286347.1 copper-transporting ATPase 2 isoform X10
XM_047430393.1 → XP_047286349.1 copper-transporting ATPase 2 isoform X12
XM_047430392.1 → XP_047286348.1 copper-transporting ATPase 2 isoform X11