Format

Send to:

Choose Destination
    • Showing Current items.

    EXOSC10 exosome component 10 [ Homo sapiens (human) ]

    Gene ID: 5394, updated on 4-Nov-2018

    Summary

    Official Symbol
    EXOSC10provided by HGNC
    Official Full Name
    exosome component 10provided by HGNC
    Primary source
    HGNC:HGNC:9138
    See related
    Ensembl:ENSG00000171824 MIM:605960; Vega:OTTHUMG00000002123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p2; p3; p4; RRP6; PMSCL; Rrp6p; PM-Scl; PMSCL2; PM/Scl-100
    Expression
    Ubiquitous expression in skin (RPKM 18.4), testis (RPKM 18.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See EXOSC10 in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (11066613..11099910, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11126675..11159961, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TAR DNA binding protein Neighboring gene mannan binding lectin serine peptidase 2 Neighboring gene spermidine synthase Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene MTOR antisense RNA 1 Neighboring gene RNA, U6 small nuclear 537, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of exosome component 10 (EXOSC10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with exosome component 10 (EXOSC10) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
      Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • rRNA processing, organism-specific biosystem (from REACTOME)
      rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity EXP
    Inferred from Experiment
    more info
    PubMed 
    3'-5'-exoribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA binding HDA PubMed 
    exoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    telomerase RNA binding IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptionally active chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    exosome component 10
    Names
    P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
    autoantigen PM-SCL
    polymyositis/scleroderma autoantigen 100 kDa
    polymyositis/scleroderma autoantigen 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001998.2NP_001001998.1  exosome component 10 isoform 1

      See identical proteins and their annotated locations for NP_001001998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC028687, BC073788, CA307576, DA505395
      Consensus CDS
      CCDS30584.1
      UniProtKB/Swiss-Prot
      Q01780
      Related
      ENSP00000366135.4, OTTHUMP00000002176, ENST00000376936.8, OTTHUMT00000006078
      Conserved Domains (3) summary
      cd06147
      Location:284474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46132
      PMC2NT; PMC2NT (NUC016) domain
    2. NM_002685.3NP_002676.1  exosome component 10 isoform 2

      See identical proteins and their annotated locations for NP_002676.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC028687, BC073788, CA307576, DA505395, L01457
      Consensus CDS
      CCDS126.1
      UniProtKB/Swiss-Prot
      Q01780
      Related
      ENSP00000307307.7, OTTHUMP00000002177, ENST00000304457.11, OTTHUMT00000006079
      Conserved Domains (3) summary
      cd06147
      Location:284474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46132
      PMC2NT; PMC2NT (NUC016) domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      11066613..11099910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263475.2XP_005263532.2  exosome component 10 isoform X1

      Conserved Domains (3) summary
      cd06147
      Location:284474
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:503583
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:46132
      PMC2NT; PMC2NT (NUC016) domain
    2. XM_017001497.2XP_016856986.1  exosome component 10 isoform X3

    3. XM_017001495.2XP_016856984.1  exosome component 10 isoform X2

    RNA

    1. XR_002956819.1 RNA Sequence

    2. XR_002956818.1 RNA Sequence

    3. XR_002956822.1 RNA Sequence

    4. XR_002956821.1 RNA Sequence

    5. XR_002956820.1 RNA Sequence

    Support Center