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    PLS3 plastin 3 [ Homo sapiens (human) ]

    Gene ID: 5358, updated on 23-Nov-2021

    Summary

    Official Symbol
    PLS3provided by HGNC
    Official Full Name
    plastin 3provided by HGNC
    Primary source
    HGNC:HGNC:9091
    See related
    Ensembl:ENSG00000102024 MIM:300131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMND18; T-plastin
    Summary
    Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 88.8), lung (RPKM 70.6) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PLS3 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (115561174..115650861)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114795501..114885181)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene tubulin alpha pseudogene 6 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 Neighboring gene PLS3 antisense RNA 1 Neighboring gene PHD finger-like domain-containing protein 5A pseudogene Neighboring gene PHD finger protein 5F pseudogene Neighboring gene argininosuccinate synthetase 1 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env HIV-1 gp120 upregulates the expression of T-plastin and downregulates the expression of L-plastin in T-cell lines PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686G1497

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    plastin-3
    Names
    T fimbrin
    T plastin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012518.2 RefSeqGene

      Range
      5296..94983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136025.5NP_001129497.1  plastin-3 isoform 1

      See identical proteins and their annotated locations for NP_001129497.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA704125, BC039049, BM979335, DC357886
      Consensus CDS
      CCDS14568.1
      UniProtKB/Swiss-Prot
      P13797
      Related
      ENSP00000445339.2, ENST00000539310.5
      Conserved Domains (5) summary
      cd00051
      Location:1682
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:101245
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21328
      Location:254375
      CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
      cd21331
      Location:377510
      CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
      cd21334
      Location:519630
      CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
    2. NM_001172335.3NP_001165806.1  plastin-3 isoform 2

      See identical proteins and their annotated locations for NP_001165806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' non-coding exon, and uses an alternate in-frame donor splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AA704125, AK298530, BC039049, BM979335
      UniProtKB/Swiss-Prot
      P13797
      UniProtKB/TrEMBL
      B4DPW9
      Conserved Domains (2) summary
      COG5069
      Location:79596
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cl08302
      Location:1649
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. NM_001282337.2NP_001269266.1  plastin-3 isoform 3

      See identical proteins and their annotated locations for NP_001269266.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an exon in the 5' region (which results in the use of an alternate translation initiation codon) and another in-frame exon in the mid-coding region, which are not found in variant 1. The encoded isoform (3) is shorter with a distinct N-terminus, and contains a novel 9 aa protein segment compared to isoform 1.
      Source sequence(s)
      AA704125, AK294509, BC039049, BM979335, DC320695, M34427
      Consensus CDS
      CCDS78499.1
      UniProtKB/Swiss-Prot
      P13797
      Related
      ENSP00000289290.4, ENST00000289290.7
      Conserved Domains (2) summary
      COG5069
      Location:45610
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00051
      Location:360
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    4. NM_001282338.2NP_001269267.1  plastin-3 isoform 4

      See identical proteins and their annotated locations for NP_001269267.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' non-coding exon and a novel exon in the 5' region that results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA704125, AK300575, BC039049, BM979335, DC357886
      UniProtKB/Swiss-Prot
      P13797
      Conserved Domains (4) summary
      smart00033
      Location:356459
      CH; Calponin homology domain
      cd00014
      Location:79194
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam13499
      Location:136
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:637
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    5. NM_005032.7NP_005023.2  plastin-3 isoform 1

      See identical proteins and their annotated locations for NP_005023.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AA704125, AK312391, BC039049, BM979335, DC320695, M34427
      Consensus CDS
      CCDS14568.1
      UniProtKB/Swiss-Prot
      P13797
      Related
      ENSP00000348163.3, ENST00000355899.8
      Conserved Domains (5) summary
      cd00051
      Location:1682
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:101245
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21328
      Location:254375
      CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
      cd21331
      Location:377510
      CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
      cd21334
      Location:519630
      CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      115561174..115650861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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