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    PI4KB phosphatidylinositol 4-kinase beta [ Homo sapiens (human) ]

    Gene ID: 5298, updated on 3-Mar-2019

    Summary

    Official Symbol
    PI4KBprovided by HGNC
    Official Full Name
    phosphatidylinositol 4-kinase betaprovided by HGNC
    Primary source
    HGNC:HGNC:8984
    See related
    Ensembl:ENSG00000143393 MIM:602758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPIK; PI4K92; PIK4CB; PI4KBETA; PI4K-BETA; PI4KIIIBETA
    Expression
    Ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See PI4KB in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (151291797..151327715, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151264273..151300191, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 4 Neighboring gene ZNF687 antisense RNA 1 Neighboring gene zinc finger protein 687 Neighboring gene RNA, 7SL, cytoplasmic 444, pseudogene Neighboring gene regulatory factor X5 Neighboring gene glioblastoma multiforme-associated transcript 2 Neighboring gene selenium binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ30129, DKFZp686O1820

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    1-phosphatidylinositol 4-kinase activity TAS
    Traceable Author Statement
    more info
     
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-kinase beta
    Names
    PtdIns 4-kinase beta
    phosphatidylinositol 4-kinase, catalytic, beta
    phosphatidylinositol 4-kinase, wortmannin-sensitive
    type III phosphatidylinositol 4-kinase beta
    NP_001185702.1
    NP_001185703.1
    NP_001185704.1
    NP_001317650.1
    NP_002642.1
    XP_005245321.1
    XP_011507936.1
    XP_011507937.1
    XP_011507938.1
    XP_011507939.1
    XP_011507940.1
    XP_016856975.1
    XP_016856976.1
    XP_016856977.1
    XP_016856979.1
    XP_016856980.1
    XP_016856981.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198773.2NP_001185702.1  phosphatidylinositol 4-kinase beta isoform 2

      See identical proteins and their annotated locations for NP_001185702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' region, resulting in a downstream AUG start codon, and also lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB005910, AK311292, AL391069, BC040300, U81802
      Consensus CDS
      CCDS55638.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000357866.1, ENST00000368872.5
      Conserved Domains (1) summary
      cd05168
      Location:514801
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    2. NM_001198774.1NP_001185703.1  phosphatidylinositol 4-kinase beta isoform 2

      See identical proteins and their annotated locations for NP_001185703.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two separated exons in the 5' region, as compared to variant 2. The resulting isoform (2) has a shorter N-terminus and lacks an internal segment, as compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AB005910, AL391069, BC040300
      Consensus CDS
      CCDS55638.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000357868.4, ENST00000368874.8
      Conserved Domains (1) summary
      cd05168
      Location:514801
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    3. NM_001198775.2NP_001185704.1  phosphatidylinositol 4-kinase beta isoform 3

      See identical proteins and their annotated locations for NP_001185704.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three consecutive exons in the 5' region, as compared to variant 1. The resulting in isoform (3) has a much shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK294606, AL391069, BC000029, BC040300, DC350175, DC365634
      Consensus CDS
      CCDS55637.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000433149.1, ENST00000529142.5
      Conserved Domains (1) summary
      cd05168
      Location:197484
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    4. NM_001330721.1NP_001317650.1  phosphatidylinositol 4-kinase beta isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL391069, KF459527
      Consensus CDS
      CCDS81376.1
      UniProtKB/Swiss-Prot
      Q9UBF8
    5. NM_002651.3NP_002642.1  phosphatidylinositol 4-kinase beta isoform 1

      See identical proteins and their annotated locations for NP_002642.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB005910, AK311292, AL391069, BC040300
      Consensus CDS
      CCDS993.1
      UniProtKB/Swiss-Prot
      Q9UBF8
      UniProtKB/TrEMBL
      A0A0B4J1S8
      Related
      ENSP00000357869.2, ENST00000368875.6
      Conserved Domains (1) summary
      cd05168
      Location:541828
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      151291797..151327715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001487.1XP_016856976.1  phosphatidylinositol 4-kinase beta isoform X4

    2. XM_017001490.1XP_016856979.1  phosphatidylinositol 4-kinase beta isoform X5

      UniProtKB/Swiss-Prot
      Q9UBF8
      Related
      ENSP00000357867.1, ENST00000368873.5
      Conserved Domains (1) summary
      cd05168
      Location:529816
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    3. XM_011509636.2XP_011507938.1  phosphatidylinositol 4-kinase beta isoform X2

      See identical proteins and their annotated locations for XP_011507938.1

      Conserved Domains (1) summary
      cd05168
      Location:529837
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    4. XM_017001492.1XP_016856981.1  phosphatidylinositol 4-kinase beta isoform X7

      UniProtKB/Swiss-Prot
      Q9UBF8
      Conserved Domains (1) summary
      cd05168
      Location:514801
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    5. XM_017001488.1XP_016856977.1  phosphatidylinositol 4-kinase beta isoform X4

    6. XM_017001491.1XP_016856980.1  phosphatidylinositol 4-kinase beta isoform X5

      UniProtKB/Swiss-Prot
      Q9UBF8
      Conserved Domains (1) summary
      cd05168
      Location:529816
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    7. XM_011509637.2XP_011507939.1  phosphatidylinositol 4-kinase beta isoform X2

      See identical proteins and their annotated locations for XP_011507939.1

      Conserved Domains (1) summary
      cd05168
      Location:529837
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    8. XM_005245264.3XP_005245321.1  phosphatidylinositol 4-kinase beta isoform X6

      Conserved Domains (1) summary
      cd05168
      Location:526813
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    9. XM_011509638.1XP_011507940.1  phosphatidylinositol 4-kinase beta isoform X3

      Conserved Domains (1) summary
      cd05168
      Location:526834
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    10. XM_011509634.1XP_011507936.1  phosphatidylinositol 4-kinase beta isoform X1

      Conserved Domains (1) summary
      cd05168
      Location:541849
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    11. XM_017001486.1XP_016856975.1  phosphatidylinositol 4-kinase beta isoform X4

    12. XM_011509635.1XP_011507937.1  phosphatidylinositol 4-kinase beta isoform X2

      See identical proteins and their annotated locations for XP_011507937.1

      Conserved Domains (1) summary
      cd05168
      Location:529837
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
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