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    PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [ Homo sapiens (human) ]

    Gene ID: 5293, updated on 25-Oct-2020

    Summary

    Official Symbol
    PIK3CDprovided by HGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaprovided by HGNC
    Primary source
    HGNC:HGNC:8977
    See related
    Ensembl:ENSG00000171608 MIM:602839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APDS; PI3K; IMD14; p110D; P110DELTA
    Summary
    Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
    Expression
    Broad expression in lymph node (RPKM 21.4), bone marrow (RPKM 20.0) and 22 other tissues See more
    Orthologs

    Genomic context

    See PIK3CD in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9629889..9729114)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9711789..9789172)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 67 enhancer Neighboring gene uncharacterized LOC105376712 Neighboring gene PIK3CD antisense RNA 1 Neighboring gene PIK3CD antisense RNA 2 Neighboring gene ribosomal protein L26 pseudogene 7 Neighboring gene calsyntenin 1 Neighboring gene mitotic spindle organizing protein 1 pseudogene 1 Neighboring gene uncharacterized LOC105376717 Neighboring gene catenin beta interacting protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
    env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
    env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
    env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
    env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
    env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
    env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
    env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
    Nef nef HIV-1 Nef involves the PI3K-PKC pathway for induction of IL6 and CXCL8 (IL8) expression PubMed
    nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
    nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
    nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
    nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
    nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
    Tat tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
    tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
    tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
    tat Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells PubMed
    tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
    tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
    tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
    tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
    tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
    tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
    tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed
    tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed
    Vpr vpr HIV-1 Vpr induced upregulation of IL6 involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed
    vpr HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    1-phosphatidylinositol-3-kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol 3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatidylinositol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-3,4-bisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    B cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    B cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    adaptive immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine production TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    mast cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    mast cell degranulation TAS
    Traceable Author Statement
    more info
    PubMed 
    mast cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    natural killer cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    natural killer cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    natural killer cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    neutrophil extravasation TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neutrophil apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of protein kinase B signaling TAS
    Traceable Author Statement
    more info
     
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    respiratory burst involved in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Names
    PI3-kinase p110 subunit delta
    PI3Kdelta
    phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 20
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20
    phosphoinositide-3-kinase C
    phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta
    ptdIns-3-kinase subunit p110-delta
    NP_001337163.1
    NP_001337164.1
    NP_005017.3
    XP_006710750.1
    XP_006710752.1
    XP_016856965.1
    XP_016856966.1
    XP_016856967.1
    XP_016856968.1
    XP_016856969.1
    XP_016856970.1
    XP_016856971.1
    XP_016856972.1
    XP_024303429.1
    XP_024303431.1
    XP_024303432.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023434.1 RefSeqGene

      Range
      5001..82383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_191

    mRNA and Protein(s)

    1. NM_001350234.2NP_001337163.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL691449, BC132919, BC150297, CA427830, DA318970, DB216922, U86453, W30913, Y10055
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505683
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6751041
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    2. NM_001350235.1NP_001337164.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 3

      Status: REVIEWED

      Source sequence(s)
      BC132919, BC150297, CA427830, DA318970, U86453, W30913, Y10055
      Conserved Domains (5) summary
      cd08693
      Location:285452
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:474655
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6471013
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175261
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    3. NM_005026.5NP_005017.3  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1

      See identical proteins and their annotated locations for NP_005017.3

      Status: REVIEWED

      Source sequence(s)
      AK314191, AL691449, BC030263, BC132919, BC150297, CA427830, U86453, W30913, Y10055
      Consensus CDS
      CCDS104.1
      UniProtKB/Swiss-Prot
      O00329
      Related
      ENSP00000366563.4, ENST00000377346.9
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:503684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      9629889..9729114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001477.1XP_016856966.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    2. XM_017001478.1XP_016856967.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    3. XM_017001480.1XP_016856969.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    4. XM_006710689.2XP_006710752.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

      See identical proteins and their annotated locations for XP_006710752.1

      UniProtKB/Swiss-Prot
      O00329
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:503684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    5. XM_024447664.1XP_024303432.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

      Conserved Domains (5) summary
      cd08693
      Location:285452
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:474655
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6471013
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175261
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    6. XM_024447661.1XP_024303429.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    7. XM_024447663.1XP_024303431.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505683
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6751041
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    8. XM_017001483.2XP_016856972.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

      Related
      ENSP00000486826.1, ENST00000628140.2
    9. XM_017001479.1XP_016856968.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Related
      ENSP00000354410.2, ENST00000361110.6
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    10. XM_017001481.1XP_016856970.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    11. XM_017001476.1XP_016856965.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    12. XM_006710687.2XP_006710750.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

      See identical proteins and their annotated locations for XP_006710750.1

      UniProtKB/Swiss-Prot
      O00329
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:503684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    13. XM_017001482.2XP_016856971.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:562743
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7351101
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:175281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    RNA

    1. XR_002956806.1 RNA Sequence

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