Format

Send to:

Choose Destination
    • Showing Current items.

    Rgs14 regulator of G-protein signaling 14 [ Mus musculus (house mouse) ]

    Gene ID: 51791, updated on 15-Feb-2018
    Official Symbol
    Rgs14provided by MGI
    Official Full Name
    regulator of G-protein signaling 14provided by MGI
    Primary source
    MGI:MGI:1859709
    See related
    Ensembl:ENSMUSG00000052087 Vega:OTTMUSG00000033508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPIP1
    Expression
    Biased expression in thymus adult (RPKM 63.5), spleen adult (RPKM 29.2) and 7 other tissues See more
    Orthologs
    Location:
    13 B1; 13 29.8 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (55369712..55384691)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55471093..55486048)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 Neighboring gene Max dimerization protein 3 Neighboring gene lectin, mannose-binding 2 Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII (Hageman factor)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity, downstream of receptor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term synaptic potentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA-templated transcription in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    zygote asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    regulator of G-protein signaling 14
    Names
    RAP1/RAP2-interacting protein
    rap1/rap2 interacting protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360714.1NP_001347643.1  regulator of G-protein signaling 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009762
      Conserved Domains (3) summary
      cd01817
      Location:304377
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      cl25424
      Location:385445
      TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
    2. NM_016758.3NP_058038.2  regulator of G-protein signaling 14 isoform 1

      See identical proteins and their annotated locations for NP_058038.2

      Status: VALIDATED

      Source sequence(s)
      CT009762
      Consensus CDS
      CCDS36674.1
      UniProtKB/Swiss-Prot
      P97492
      Related
      ENSMUSP00000068731.7, OTTMUSP00000045408, ENSMUST00000063771.13, OTTMUST00000084287
      Conserved Domains (4) summary
      cd01817
      Location:304377
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      smart00390
      Location:500522
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cl00155
      Location:385445
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      55369712..55384691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244541.1XP_011242843.1  regulator of G-protein signaling 14 isoform X1

      Conserved Domains (3) summary
      cd01817
      Location:304377
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      cl25424
      Location:385445
      TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
    Support Center