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    SHC1 SHC adaptor protein 1 [ Bos taurus (cattle) ]

    Gene ID: 507196, updated on 24-Feb-2019

    Summary

    Official Symbol
    SHC1provided by VGNC
    Official Full Name
    SHC adaptor protein 1provided by VGNC
    Primary source
    VGNC:VGNC:34590
    See related
    BGD:BT18799; Ensembl:ENSBTAG00000019838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    p66shc
    Orthologs

    Genomic context

    See SHC1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 3 NC_037330.1 (15616336..15626916)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 3 AC_000160.1 (15671273..15681845)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene pygopus family PHD finger 2 Neighboring gene PBX homeobox interacting protein 1 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SHC-transforming protein 1
    Names
    SH2 domain protein C1
    SHC (Src homology 2 domain containing) transforming protein 1
    src homology 2 domain-containing-transforming protein C1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075305.2NP_001068773.1  SHC-transforming protein 1 isoform b

      See identical proteins and their annotated locations for NP_001068773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      BC122688, EH179100, EV724133
      UniProtKB/Swiss-Prot
      Q0IIE2
      Related
      ENSBTAP00000040041.3, ENSBTAT00000040264.4
      Conserved Domains (3) summary
      cd09925
      Location:370473
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:264400
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    2. NM_001164061.1NP_001157533.1  SHC-transforming protein 1 isoform a

      See identical proteins and their annotated locations for NP_001157533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC122688, EE957359, EV724133
      UniProtKB/Swiss-Prot
      Q0IIE2
      UniProtKB/TrEMBL
      E1B716
      Related
      ENSBTAP00000026432.4, ENSBTAT00000026432.5
      Conserved Domains (2) summary
      cd09925
      Location:480583
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      15616336..15626916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986729.1XP_024842497.1  SHC-transforming protein 1 isoform X7

      Related
      ENSBTAP00000062285.1, ENSBTAT00000075224.1
      Conserved Domains (3) summary
      cd09925
      Location:370473
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:264400
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    2. XM_010802891.3XP_010801193.1  SHC-transforming protein 1 isoform X6

      See identical proteins and their annotated locations for XP_010801193.1

      Conserved Domains (3) summary
      cd09925
      Location:371474
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:264394
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    3. XM_005203675.4XP_005203732.1  SHC-transforming protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005203732.1

      Conserved Domains (2) summary
      cd09925
      Location:389492
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36225
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    4. XM_005203673.4XP_005203730.1  SHC-transforming protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005203730.1

      Conserved Domains (2) summary
      cd09925
      Location:392495
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:39228
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    5. XM_024986719.1XP_024842487.1  SHC-transforming protein 1 isoform X5

      Conserved Domains (3) summary
      cd09925
      Location:373476
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:39210
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:267396
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    6. XM_005203676.4XP_005203733.1  SHC-transforming protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005203733.1

      Conserved Domains (2) summary
      cd09925
      Location:389492
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36225
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    7. XM_010802890.3XP_010801192.1  SHC-transforming protein 1 isoform X6

      See identical proteins and their annotated locations for XP_010801192.1

      Conserved Domains (3) summary
      cd09925
      Location:371474
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:264394
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    8. XM_024986715.1XP_024842483.1  SHC-transforming protein 1 isoform X4

      Conserved Domains (3) summary
      cd09925
      Location:374477
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:39210
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:267397
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    9. XM_024986737.1XP_024842505.1  SHC-transforming protein 1 isoform X7

      Conserved Domains (3) summary
      cd09925
      Location:370473
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
      cl26386
      Location:264400
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    10. XM_010802888.3XP_010801190.1  SHC-transforming protein 1 isoform X2

      See identical proteins and their annotated locations for XP_010801190.1

      Conserved Domains (2) summary
      cd09925
      Location:392495
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:39228
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    11. XM_005203672.4XP_005203729.1  SHC-transforming protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005203729.1

      Conserved Domains (2) summary
      cd09925
      Location:481584
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
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