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    Slc23a1 solute carrier family 23 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50621, updated on 10-Jul-2024

    Summary

    Official Symbol
    Slc23a1provided by RGD
    Official Full Name
    solute carrier family 23 member 1provided by RGD
    Primary source
    RGD:619875
    See related
    EnsemblRapid:ENSRNOG00000061695 AllianceGenome:RGD:619875
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SVCT1
    Summary
    Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Located in basal plasma membrane; brush border; and cytoplasm. Orthologous to human SLC23A1 (solute carrier family 23 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 264.2), Liver (RPKM 172.8) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Slc23a1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27490549..27504563, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27214940..27230564, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28413910..28428133, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene matrin 3 Neighboring gene small nucleolar RNA host gene 4 (non-protein coding) Neighboring gene poly(A) binding protein interacting protein 2 Neighboring gene marginal zone B and B1 cell-specific protein Neighboring gene proline-rich basic protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-ascorbate:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-ascorbate:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables L-ascorbate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-ascorbate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-ascorbate:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables L-ascorbic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-ascorbic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-ascorbic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dehydroascorbic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dehydroascorbic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dehydroascorbic acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables urate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables urate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-ascorbic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-ascorbic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in L-ascorbic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-ascorbic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dehydroascorbic acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dehydroascorbic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dehydroascorbic acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to toxic substance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in urate transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 23 member 1
    Names
    Na(+)/L-ascorbic acid transporter 1
    sodium-coupled ascorbic acid transporter 1
    sodium-dependent vitamin C transporter 1
    solute carrier family 23 (ascorbic acid transporter), member 1
    solute carrier family 23 (nucleobase transporters), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017315.2NP_059011.1  solute carrier family 23 member 1

      See identical proteins and their annotated locations for NP_059011.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078851
      UniProtKB/Swiss-Prot
      Q9WTW7
      UniProtKB/TrEMBL
      A6J2Y7
      Conserved Domains (1) summary
      pfam00860
      Location:52479
      Xan_ur_permease; Permease family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      27490549..27504563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254602.5XP_006254664.1  solute carrier family 23 member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R5A1
      Related
      ENSRNOP00000072205.2, ENSRNOT00000084372.3
      Conserved Domains (2) summary
      pfam00860
      Location:114541
      Xan_ur_permease; Permease family
      cl23746
      Location:97551
      HCO3_cotransp; HCO3- transporter family