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    ITSN2 intersectin 2 [ Homo sapiens (human) ]

    Gene ID: 50618, updated on 9-Dec-2018

    Summary

    Official Symbol
    ITSN2provided by HGNC
    Official Full Name
    intersectin 2provided by HGNC
    Primary source
    HGNC:HGNC:6184
    See related
    Ensembl:ENSG00000198399 MIM:604464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SWA; SWAP; SH3D1B; SH3P18; PRO2015
    Summary
    This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.9), lymph node (RPKM 13.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See ITSN2 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (24202864..24360538, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24425733..24583647, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228 member B Neighboring gene uncharacterized LOC105374328 Neighboring gene family with sequence similarity 228 member A Neighboring gene ribosomal protein L36a pseudogene 13 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 20 Neighboring gene uncharacterized LOC105374329 Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, 5S ribosomal pseudogene 88

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
    NHGRI GWA Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of intersectin 2 (ITSN2; SH3P18) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of CDC42 activity, organism-specific biosystem
      Regulation of CDC42 activity
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1256

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendrite extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    intersectin-2
    Names
    SH3 domain-containing protein 1B
    SH3P18-like WASP-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029516.1 RefSeqGene

      Range
      5001..162663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348181.1NP_001335110.1  intersectin-2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008073, AC009228
      Conserved Domains (12) summary
      cd08375
      Location:15411675
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:745801
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:888939
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9711022
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10431101
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11161169
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12001380
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:801888
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13981540
      PH_13; Pleckstrin homology domain
      cl26511
      Location:332742
      Neuromodulin_N; Gap junction protein N-terminal region
    2. NM_001348182.1NP_001335111.1  intersectin-2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008073, AC009228
      Conserved Domains (12) summary
      cd08375
      Location:15151649
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:719775
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:862913
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:945996
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10171075
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10901143
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:11741354
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16617
      Location:775862
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13721514
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377719
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27427
      Location:126200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    3. NM_001348183.1NP_001335112.1  intersectin-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC009228
      Conserved Domains (9) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:732788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9581009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10301088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11031156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:377727
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001348184.1NP_001335113.1  intersectin-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC009228
      Conserved Domains (9) summary
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:718774
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:861912
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:944995
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10161074
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10891142
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:774861
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:363713
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001348185.1NP_001335114.1  intersectin-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC009228
      Conserved Domains (9) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:746802
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:889940
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9721023
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10441102
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11171170
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam16617
      Location:802889
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl26511
      Location:346743
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27427
      Location:126200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    6. NM_001348186.1NP_001335115.1  intersectin-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC009228
      Conserved Domains (9) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:719775
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:862913
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:945996
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10171075
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10901143
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam16617
      Location:775862
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl25732
      Location:377719
      SMC_N; RecF/RecN/SMC N terminal domain
      cl27427
      Location:126200
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    7. NM_006277.2NP_006268.2  intersectin-2 isoform 1

      See identical proteins and their annotated locations for NP_006268.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as ITSN2-L, encodes the longest isoform (1).
      Source sequence(s)
      AF182198, BC146779, DA382952
      Consensus CDS
      CCDS1710.2
      UniProtKB/Swiss-Prot
      Q9NZM3
      UniProtKB/TrEMBL
      A6H8W8
      Related
      ENSP00000347244.4, ENST00000355123.8
      Conserved Domains (12) summary
      cd08375
      Location:15551689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12141394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:815902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:14121554
      PH_13; Pleckstrin homology domain
      cl26511
      Location:346756
      Neuromodulin_N; Gap junction protein N-terminal region
    8. NM_019595.3NP_062541.3  intersectin-2 isoform 3

      See identical proteins and their annotated locations for NP_062541.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 3) that lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF182198, AF182199, BC146779, DA382952
      Consensus CDS
      CCDS1711.2
      UniProtKB/Swiss-Prot
      Q9NZM3
      UniProtKB/TrEMBL
      A6H8W8
      Related
      ENSP00000354561.2, ENST00000361999.7
      Conserved Domains (12) summary
      cd08375
      Location:15281662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:732788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9581009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10301088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11031156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:11871367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13851527
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377727
      SMC_N; RecF/RecN/SMC N terminal domain
    9. NM_147152.2NP_671494.2  intersectin-2 isoform 2

      See identical proteins and their annotated locations for NP_671494.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as ITSN2-S1, has an alternate 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF038189, AF182199, DA382952
      Consensus CDS
      CCDS46230.1
      UniProtKB/Swiss-Prot
      Q9NZM3
      Related
      ENSP00000384499.3, ENST00000406921.7
      Conserved Domains (13) summary
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      cd00052
      Location:248314
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam08496
      Location:692757
      Peptidase_S49_N; Peptidase family S49 N-terminal
      pfam13499
      Location:249306
      EF-hand_7; EF-hand domain pair
      pfam13868
      Location:387741
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:815902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:454465
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:379484
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      24202864..24360538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452935.1XP_024308703.1  intersectin-2 isoform X5

      Conserved Domains (12) summary
      cd08375
      Location:15141648
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:718774
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:861912
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:944995
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10161074
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:10891142
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:11731353
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:774861
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13711513
      PH_13; Pleckstrin homology domain
      cl25732
      Location:363713
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_024452933.1XP_024308701.1  intersectin-2 isoform X3

      Conserved Domains (12) summary
      cd08375
      Location:15421676
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:746802
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:889940
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9721023
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10441102
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11171170
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12011381
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:802889
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13991541
      PH_13; Pleckstrin homology domain
      cl26511
      Location:346743
      Neuromodulin_N; Gap junction protein N-terminal region
    3. XM_024452931.1XP_024308699.1  intersectin-2 isoform X1

      Conserved Domains (12) summary
      cd08375
      Location:15551689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12141394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:815902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:14121554
      PH_13; Pleckstrin homology domain
      cl26511
      Location:346756
      Neuromodulin_N; Gap junction protein N-terminal region
    4. XM_024452932.1XP_024308700.1  intersectin-2 isoform X2

      Conserved Domains (12) summary
      cd08375
      Location:15411675
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:745801
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:888939
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9711022
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10431101
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11161169
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12001380
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:801888
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13981540
      PH_13; Pleckstrin homology domain
      cl26511
      Location:332742
      Neuromodulin_N; Gap junction protein N-terminal region
    5. XM_024452930.1XP_024308698.1  intersectin-2 isoform X1

      Conserved Domains (12) summary
      cd08375
      Location:15551689
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:759815
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:902953
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9851036
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10571115
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11301183
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:12141394
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:815902
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:14121554
      PH_13; Pleckstrin homology domain
      cl26511
      Location:346756
      Neuromodulin_N; Gap junction protein N-terminal region
    6. XM_024452937.1XP_024308705.1  intersectin-2 isoform X7

      Conserved Domains (9) summary
      cd08375
      Location:787921
      C2_Intersectin; C2 domain present in Intersectin
      cd11990
      Location:134185
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:217268
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:289347
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:362415
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:446626
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam16617
      Location:47134
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:644786
      PH_13; Pleckstrin homology domain
      cl17036
      Location:1547
      SH3; Src Homology 3 domain superfamily
    7. XM_024452934.1XP_024308702.1  intersectin-2 isoform X4

      Conserved Domains (12) summary
      cd08375
      Location:15281662
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:15107
      EH; Eps15 homology domain
      cd11988
      Location:732788
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:875926
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9581009
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10301088
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11031156
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      smart00325
      Location:11871367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam15279
      Location:90182
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:788875
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:13851527
      PH_13; Pleckstrin homology domain
      cl25732
      Location:377727
      SMC_N; RecF/RecN/SMC N terminal domain
    8. XM_024452936.1XP_024308704.1  intersectin-2 isoform X6

      Conserved Domains (9) summary
      smart00027
      Location:193
      EH; Eps15 homology domain
      cd11988
      Location:745801
      SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
      cd11990
      Location:888939
      SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
      cd11992
      Location:9711022
      SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
      cd11994
      Location:10431101
      SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
      cd11996
      Location:11161169
      SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
      pfam15279
      Location:76168
      SOBP; Sine oculis-binding protein
      pfam16617
      Location:801888
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cl26511
      Location:332742
      Neuromodulin_N; Gap junction protein N-terminal region

    RNA

    1. XR_002959302.1 RNA Sequence

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