Format

Send to:

Choose Destination
    • Showing Current items.

    OGN osteoglycin [ Homo sapiens (human) ]

    Gene ID: 4969, updated on 5-Aug-2018

    Summary

    Official Symbol
    OGNprovided by HGNC
    Official Full Name
    osteoglycinprovided by HGNC
    Primary source
    HGNC:HGNC:8126
    See related
    Ensembl:ENSG00000106809 MIM:602383; Vega:OTTHUMG00000020224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OG; OIF; SLRR3A
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues See more
    Orthologs

    Genomic context

    See OGN in Genome Data Viewer
    Location:
    9q22.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (92383271..92404699, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95146249..95166976, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nucleolar protein 8 Neighboring gene chromosome 16 open reading frame 70 pseudogene Neighboring gene centromere protein P Neighboring gene osteomodulin Neighboring gene asporin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), organism-specific biosystem (from REACTOME)
      Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), organism-specific biosystemCongenital disorders of glycosylation (CDG, previously called carbohydrate-deficient glycoprotein syndromes, CDGSs), are a group of hereditary multisystem disorders. They are characterized biochemica...
    • Defective CHST6 causes MCDC1, organism-specific biosystem (from REACTOME)
      Defective CHST6 causes MCDC1, organism-specific biosystemCarbohydrate sulfotransferase 6 (CHST6) catalyzes the transfer of sulfate to position 6 of non-reducing ends of N-acetylglucosamine (GlcNAc) residues on keratan sulfate (KS). KS plays a central role ...
    • Defective ST3GAL3 causes MCT12 and EIEE15, organism-specific biosystem (from REACTOME)
      Defective ST3GAL3 causes MCT12 and EIEE15, organism-specific biosystemCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (ST3GAL3) mediates the transfer of sialic acid from CMP-sialic acid to galactose-containing glycoproteins and forms the sialyl...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases associated with glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
      Diseases associated with glycosaminoglycan metabolism, organism-specific biosystemA number of genetic disorders are caused by mutations in the genes encoding glycosyltransferases and sulfotransferases, enzymes responsible for the synthesis of glycosaminoglycans (GAGs) as well as ...
    • Diseases of glycosylation, organism-specific biosystem (from REACTOME)
      Diseases of glycosylation, organism-specific biosystemDiseases of glycosylation, usually referred to as congenital disorders of glycosylation (CDG), are rare inherited disorders ascribing defects of nucleotide-sugar biosynthesis and transport, glycosylt...
    • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
      Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
    • Keratan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
      Keratan sulfate biosynthesis, organism-specific biosystemKeratan sulfate (KSI) is the best characterised keratan sulfate. It is 10 times more abundant in cornea than cartilage. KSI is attached to an asparagine (Asn) residue on the core protein via an N-lin...
    • Keratan sulfate degradation, organism-specific biosystem (from REACTOME)
      Keratan sulfate degradation, organism-specific biosystemKeratan sulfate proteoglycans (KSPGs) are degraded in lysosomes as part of normal homeostasis of glycoproteins. Glycoproteins must be completely degraded to avoid undigested fragments building up and...
    • Keratan sulfate/keratin metabolism, organism-specific biosystem (from REACTOME)
      Keratan sulfate/keratin metabolism, organism-specific biosystemKeratan sulfate (KS) (a glycosaminoglycan, GAG) is a linear polysaccharide that consists of the repeating disaccharide unit GlcNAc-Gal (N-acetylglucosamine-galactose). KS can perform a structural fun...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp586P2421

    General protein information

    Preferred Names
    mimecan
    Names
    corneal keratan sulfate proteoglycan
    mimecan proteoglycan
    osteoinductive factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014057.4NP_054776.1  mimecan isoform 2 precursor

      See identical proteins and their annotated locations for NP_054776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (2).
      Source sequence(s)
      AF086912, AF100758, AK295433, AL137848, BM679549
      Consensus CDS
      CCDS6695.1
      UniProtKB/Swiss-Prot
      P20774
      UniProtKB/TrEMBL
      A8K0R3, B4DI63, Q7Z532
      Related
      ENSP00000364711.5, OTTHUMP00000021650, ENST00000375561.9, OTTHUMT00000053086
      Conserved Domains (2) summary
      sd00033
      Location:123144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143225
      LRR_8; Leucine rich repeat
    2. NM_024416.4NP_077727.3  mimecan isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (1) has a longer N-terminus and lacks a predicted signal peptide compared to isoform 2.
      Source sequence(s)
      AF086912, AK295433, AL137848, BC095443, BG772245, BM679549
      UniProtKB/Swiss-Prot
      P20774
      UniProtKB/TrEMBL
      B4DI63, Q7Z532
      Conserved Domains (3) summary
      sd00033
      Location:181202
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:181218
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:201283
      LRR_8; Leucine rich repeat
    3. NM_033014.3NP_148935.1  mimecan isoform 2 precursor

      See identical proteins and their annotated locations for NP_148935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (2). Both variants 1 and 3 encode the same isoform (2).
      Source sequence(s)
      AK295433, AL137848, BC095443, BG772245, BM679549, CB268982
      Consensus CDS
      CCDS6695.1
      UniProtKB/Swiss-Prot
      P20774
      UniProtKB/TrEMBL
      A8K0R3, B4DI63
      Related
      ENSP00000262551.4, OTTHUMP00000021651, ENST00000262551.8, OTTHUMT00000053087
      Conserved Domains (2) summary
      sd00033
      Location:123144
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:143225
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      92383271..92404699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center