Format

Send to:

Choose Destination
    • Showing Current items.

    NEK3 NIMA related kinase 3 [ Homo sapiens (human) ]

    Gene ID: 4752, updated on 7-Dec-2018

    Summary

    Official Symbol
    NEK3provided by HGNC
    Official Full Name
    NIMA related kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:7746
    See related
    Ensembl:ENSG00000136098 MIM:604044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPK36
    Summary
    This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
    Annotation information
    Note: Available sequence data supports two haplotypes in the human population that differ by a 1 nt indel at the end of exon 10. Both haplotypes appear to encode functional proteins via alternative splicing of exon 11. The CHM1_1.1 and HuRef assemblies lack the extra nt and express a full-length protein lacking exon 11. [23 Apr 2014]
    Expression
    Broad expression in testis (RPKM 10.8), placenta (RPKM 6.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See NEK3 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (52132643..52159861, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52706779..52733996, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 5 Neighboring gene NIMA related kinase 5 Neighboring gene uncharacterized LOC101929657 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 5 Neighboring gene thrombospondin type 1 domain containing 1 pseudogene 1 Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of tubulin deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek3
    Names
    HSPK 36
    NIMA (never in mitosis gene a)-related kinase 3
    glycogen synthase A kinase
    hydroxyalkyl-protein kinase
    never in mitosis A-related kinase 3
    nimA-related protein kinase 3
    phosphorylase B kinase kinase
    NP_002489.1
    NP_689933.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146099.1NP_001139571.1  serine/threonine-protein kinase Nek3 isoform b

      See identical proteins and their annotated locations for NP_001139571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. This variant represents an alternate haplotype that lacks an 'A' at position 1253. This haplotype is not encoded by the reference assembly.
      Source sequence(s)
      AB072828, AI026881, DA733733, DB185803
      UniProtKB/Swiss-Prot
      P51956
      Conserved Domains (1) summary
      cd08219
      Location:3257
      STKc_Nek3; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3
    2. NM_002498.3NP_002489.1  serine/threonine-protein kinase Nek3 isoform a

      See identical proteins and their annotated locations for NP_002489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AL139082, BC019916
      Consensus CDS
      CCDS73576.1
      UniProtKB/Swiss-Prot
      P51956
      Related
      ENSP00000480328.1, ENST00000610828.4
      Conserved Domains (1) summary
      cd08219
      Location:3257
      STKc_Nek3; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3
    3. NM_152720.2NP_689933.1  serine/threonine-protein kinase Nek3 isoform a

      See identical proteins and their annotated locations for NP_689933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AI209040, AK131359, AK290259, AL139082, H15146
      Consensus CDS
      CCDS73576.1
      UniProtKB/Swiss-Prot
      P51956
      UniProtKB/TrEMBL
      Q6ZN64
      Related
      ENSP00000484443.1, ENST00000618534.4
      Conserved Domains (1) summary
      cd08219
      Location:3257
      STKc_Nek3; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3

    RNA

    1. NR_027415.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the splice pattern of variant 1 but without the extra 'A' found in the alternate haplotype. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL139082, AW364762, BM675414, BX395059, CV029372, DA407862, DB185803

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      52132643..52159861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center