Format

Send to:

Choose Destination
    • Showing Current items.

    CEACAM6 carcinoembryonic antigen related cell adhesion molecule 6 [ Homo sapiens (human) ]

    Gene ID: 4680, updated on 12-Aug-2018

    Summary

    Official Symbol
    CEACAM6provided by HGNC
    Official Full Name
    carcinoembryonic antigen related cell adhesion molecule 6provided by HGNC
    Primary source
    HGNC:HGNC:1818
    See related
    Ensembl:ENSG00000086548 MIM:163980; Vega:OTTHUMG00000151064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCA; CEAL; CD66c
    Summary
    This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in colon (RPKM 147.4), lung (RPKM 142.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See CEACAM6 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (41755520..41772211)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42259398..42276113)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule 7 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 1 pseudogene Neighboring gene carcinoembryonic antigen related cell adhesion molecule 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Fibronectin matrix formation, organism-specific biosystem (from REACTOME)
      Fibronectin matrix formation, organism-specific biosystemFibronectin (FN1) is found in the extracellular matrix (ECM) of all cells as linear and branched networks that surround and connect neighbouring cells (Singh et al. 2010). Prior to matrix formation F...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    cell surface IC
    Inferred by Curator
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 6
    Names
    Cluster of Differentiation 66c
    carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
    normal cross-reacting antigen

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002483.6NP_002474.4  carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein

      See identical proteins and their annotated locations for NP_002474.4

      Status: REVIEWED

      Source sequence(s)
      AK312542, BC005008, DA763751, M18728
      Consensus CDS
      CCDS12585.1
      UniProtKB/Swiss-Prot
      P40199
      Related
      ENSP00000199764.6, OTTHUMP00000199042, ENST00000199764.6, OTTHUMT00000321147
      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244312
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146234
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      41755520..41772211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526990.2XP_011525292.1  carcinoembryonic antigen-related cell adhesion molecule 6 isoform X1

      See identical proteins and their annotated locations for XP_011525292.1

      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244312
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146234
      Ig; Immunoglobulin domain
    Support Center