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    MYO10 myosin X [ Homo sapiens (human) ]

    Gene ID: 4651, updated on 12-Aug-2018

    Summary

    Official Symbol
    MYO10provided by HGNC
    Official Full Name
    myosin Xprovided by HGNC
    Primary source
    HGNC:HGNC:7593
    See related
    Ensembl:ENSG00000145555 MIM:601481; Vega:OTTHUMG00000161822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues See more
    Orthologs

    Genomic context

    See MYO10 in Genome Data Viewer
    Location:
    5p15.1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (16661907..16936276, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16662016..16936385, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 622 Neighboring gene reticulophagy regulator 1 Neighboring gene uncharacterized LOC101929524 Neighboring gene RNA, 5S ribosomal pseudogene 179 Neighboring gene ribosomal protein S26 pseudogene 28 Neighboring gene RNA, U6 small nuclear 660, pseudogene Neighboring gene BASP1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 180

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    NHGRI GWA Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10639, FLJ21066, FLJ22268, FLJ43256, KIAA0799, MGC131988

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin-dependent ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    motor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plus-end directed microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    cytoskeleton-dependent intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012334.2NP_036466.2  unconventional myosin-X

      See identical proteins and their annotated locations for NP_036466.2

      Status: REVIEWED

      Source sequence(s)
      AC024588, AF234532, AI086647, BC014956, BC150285, CA488271, DA504301
      Consensus CDS
      CCDS54834.1
      UniProtKB/Swiss-Prot
      Q9HD67
      Related
      ENSP00000421280.1, OTTHUMP00000220773, ENST00000513610.5, OTTHUMT00000366167
      Conserved Domains (12) summary
      smart00139
      Location:15491695
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58739
      MYSc; Myosin. Large ATPases
      smart00295
      Location:17041958
      B41; Band 4.1 homologues
      cd13202
      Location:19542042
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:12151316
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:13811506
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77727
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:12151308
      PH; PH domain
      pfam00373
      Location:17961958
      FERM_M; FERM central domain
      pfam16735
      Location:883933
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:17051753
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:11811223
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      16661907..16936276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714475.3XP_006714538.1  unconventional myosin-X isoform X1

      Conserved Domains (12) summary
      smart00139
      Location:15261672
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58716
      MYSc; Myosin. Large ATPases
      smart00295
      Location:16811935
      B41; Band 4.1 homologues
      cd13202
      Location:19312019
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:11921293
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:13581483
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77704
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:11921285
      PH; PH domain
      pfam00373
      Location:17731935
      FERM_M; FERM central domain
      pfam16735
      Location:860910
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:16821730
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:11581200
      PH-like; Pleckstrin homology-like domain
    2. XM_005248307.2XP_005248364.1  unconventional myosin-X isoform X3

      See identical proteins and their annotated locations for XP_005248364.1

      UniProtKB/Swiss-Prot
      Q9HD67
      Related
      ENSP00000421170.1, OTTHUMP00000220777, ENST00000505695.5, OTTHUMT00000366171
      Conserved Domains (11) summary
      smart00139
      Location:9061052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10611315
      B41; Band 4.1 homologues
      cd13202
      Location:13111399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572665
      PH; PH domain
      pfam00373
      Location:11531315
      FERM_M; FERM central domain
      pfam16735
      Location:240290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:10621110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538580
      PH-like; Pleckstrin homology-like domain
    3. XM_011514046.2XP_011512348.1  unconventional myosin-X isoform X3

      See identical proteins and their annotated locations for XP_011512348.1

      UniProtKB/Swiss-Prot
      Q9HD67
      Related
      ENSP00000425051.1, OTTHUMP00000220778, ENST00000515803.5, OTTHUMT00000366172
      Conserved Domains (11) summary
      smart00139
      Location:9061052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10611315
      B41; Band 4.1 homologues
      cd13202
      Location:13111399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572665
      PH; PH domain
      pfam00373
      Location:11531315
      FERM_M; FERM central domain
      pfam16735
      Location:240290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:10621110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538580
      PH-like; Pleckstrin homology-like domain
    4. XM_005248306.4XP_005248363.1  unconventional myosin-X isoform X2

      Conserved Domains (11) summary
      smart00139
      Location:9071053
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10621316
      B41; Band 4.1 homologues
      cd13202
      Location:13121400
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:573674
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:739864
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:285
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:573666
      PH; PH domain
      pfam00373
      Location:11541316
      FERM_M; FERM central domain
      pfam16735
      Location:241291
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:10631111
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:539581
      PH-like; Pleckstrin homology-like domain
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