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    MYO10 myosin X [ Homo sapiens (human) ]

    Gene ID: 4651, updated on 17-Jun-2024

    Summary

    Official Symbol
    MYO10provided by HGNC
    Official Full Name
    myosin Xprovided by HGNC
    Primary source
    HGNC:HGNC:7593
    See related
    Ensembl:ENSG00000145555 MIM:601481; AllianceGenome:HGNC:7593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MyoX
    Summary
    This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MYO10 in Genome Data Viewer
    Location:
    5p15.1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (16661907..16936288, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (16601148..16875413, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16662016..16936397, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22421 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16467094-16467316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22423 Neighboring gene zinc finger protein 622 Neighboring gene reticulophagy regulator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16535515-16536016 Neighboring gene Sharpr-MPRA regulatory region 7449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16575232-16575796 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16606665-16606881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15947 Neighboring gene RETREG1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16711171-16711672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16718131-16718712 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:16721745-16722434 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16741941-16742846 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:16741036-16741940 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:16754668-16755308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16755309-16755949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794335-16794862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794863-16795390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16805998-16806498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16806499-16806999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16809483-16809982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16829693-16830613 Neighboring gene RNA, 5S ribosomal pseudogene 179 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16897552-16898412 Neighboring gene ribosomal protein S26 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16951303-16951587 Neighboring gene RNA, U6 small nuclear 660, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16994519-16995071 Neighboring gene NANOG hESC enhancer GRCh37_chr5:17066008-17066589 Neighboring gene uncharacterized LOC124900947 Neighboring gene Sharpr-MPRA regulatory region 7707

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10639, FLJ21066, FLJ22268, FLJ43256, KIAA0799, MGC131988

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables plus-end directed microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables plus-end directed microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoskeleton-dependent intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012334.3NP_036466.2  unconventional myosin-X

      See identical proteins and their annotated locations for NP_036466.2

      Status: REVIEWED

      Source sequence(s)
      AC010607, AC024588, AF234532, AI086647, BC014956, BC150285, CA488271, DA504301
      Consensus CDS
      CCDS54834.1
      UniProtKB/Swiss-Prot
      A7E2D1, O94893, Q8IVX5, Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6
      UniProtKB/TrEMBL
      A0A0A0MQX1
      Related
      ENSP00000421280.1, ENST00000513610.6
      Conserved Domains (12) summary
      smart00139
      Location:15491695
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58739
      MYSc; Myosin. Large ATPases
      smart00295
      Location:17041958
      B41; Band 4.1 homologues
      cd13202
      Location:19542042
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:12151316
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:13811506
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77727
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:12151308
      PH; PH domain
      pfam00373
      Location:17961958
      FERM_M; FERM central domain
      pfam16735
      Location:883933
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:17051753
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:11811223
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      16661907..16936288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714475.4XP_006714538.1  unconventional myosin-X isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQX1
      Conserved Domains (12) summary
      smart00139
      Location:15261672
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58716
      MYSc; Myosin. Large ATPases
      smart00295
      Location:16811935
      B41; Band 4.1 homologues
      cd13202
      Location:19312019
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:11921293
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:13581483
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77704
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:11921285
      PH; PH domain
      pfam00373
      Location:17731935
      FERM_M; FERM central domain
      pfam16735
      Location:860910
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:16821730
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:11581200
      PH-like; Pleckstrin homology-like domain
    2. XM_005248307.3XP_005248364.1  unconventional myosin-X isoform X3

      See identical proteins and their annotated locations for XP_005248364.1

      UniProtKB/TrEMBL
      B7ZA23
      Related
      ENSP00000421170.1, ENST00000505695.5
      Conserved Domains (11) summary
      smart00139
      Location:9061052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10611315
      B41; Band 4.1 homologues
      cd13202
      Location:13111399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572665
      PH; PH domain
      pfam00373
      Location:11531315
      FERM_M; FERM central domain
      pfam16735
      Location:240290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:10621110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538580
      PH-like; Pleckstrin homology-like domain
    3. XM_011514046.3XP_011512348.1  unconventional myosin-X isoform X3

      See identical proteins and their annotated locations for XP_011512348.1

      UniProtKB/TrEMBL
      B7ZA23
      Related
      ENSP00000425051.1, ENST00000515803.5
      Conserved Domains (11) summary
      smart00139
      Location:9061052
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10611315
      B41; Band 4.1 homologues
      cd13202
      Location:13111399
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:572673
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:738863
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:572665
      PH; PH domain
      pfam00373
      Location:11531315
      FERM_M; FERM central domain
      pfam16735
      Location:240290
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:10621110
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:538580
      PH-like; Pleckstrin homology-like domain
    4. XM_005248306.5XP_005248363.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      B7ZA23
      Conserved Domains (11) summary
      smart00139
      Location:9071053
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10621316
      B41; Band 4.1 homologues
      cd13202
      Location:13121400
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:573674
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:739864
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:285
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:573666
      PH; PH domain
      pfam00373
      Location:11541316
      FERM_M; FERM central domain
      pfam16735
      Location:241291
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:10631111
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:539581
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      16601148..16875413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352663.1XP_054208638.1  unconventional myosin-X isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQX1
    2. XM_054352666.1XP_054208641.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7Z3D4, B7ZA23
    3. XM_054352665.1XP_054208640.1  unconventional myosin-X isoform X3

      UniProtKB/TrEMBL
      B7Z3D4, B7ZA23
    4. XM_054352664.1XP_054208639.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      B7ZA23