Format

Send to:

Choose Destination
    • Showing Current items.

    MYLK myosin light chain kinase [ Homo sapiens (human) ]

    Gene ID: 4638, updated on 28-Nov-2021

    Summary

    Official Symbol
    MYLKprovided by HGNC
    Official Full Name
    myosin light chain kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:7590
    See related
    Ensembl:ENSG00000065534 MIM:600922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KRP; AAT7; MLCK; MLCK1; MMIHS; MYLK1; MMIHS1; smMLCK; MLCK108; MLCK210; MSTP083
    Summary
    This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in prostate (RPKM 187.5), endometrium (RPKM 154.5) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MYLK in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (123610049..123884332, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123328896..123603179, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 5 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene MYLK antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9008 Neighboring gene uncharacterized LOC105369194 Neighboring gene MYLK antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 10510 Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in MYLK that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2016-01-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2016-01-14)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat in combination with morphine activates myosin light chain kinase expression in primary brain micro vascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12216, DKFZp686I10125

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin light chain kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables myosin light chain kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aorta smooth muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bleb assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular hypotonic response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tonic smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tonic smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myosin light chain kinase, smooth muscle
    Names
    kinase-related protein
    myosin, light polypeptide kinase
    smooth muscle myosin light chain kinase
    telokin
    NP_001308238.1
    NP_444253.3
    NP_444254.3
    NP_444255.3
    NP_444256.3
    NP_444259.1
    NP_444260.1
    XP_011511162.2
    XP_011511163.2
    XP_016861958.1
    XP_016861959.1
    XP_016861960.1
    XP_016861961.1
    XP_016861962.1
    XP_024309300.1
    XP_024309301.1
    XP_024309302.1
    XP_024309303.1
    XP_024309304.1
    XP_024309305.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029111.1 RefSeqGene

      Range
      5001..277007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321309.2NP_001308238.1  myosin light chain kinase, smooth muscle isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064695, BC113458, BQ006428, DA853780, U48959
      UniProtKB/Swiss-Prot
      Q15746
      UniProtKB/TrEMBL
      Q05B97
      Conserved Domains (9) summary
      cd00096
      Location:464533
      Ig; Immunoglobulin domain
      cd05762
      Location:10621159
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:16461713
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:11551247
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:16331723
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:12851543
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:12881543
      Pkinase; Protein kinase domain
      pfam16620
      Location:75236
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:548633
      Ig; Immunoglobulin domain
    2. NM_053025.4NP_444253.3  myosin light chain kinase, smooth muscle isoform 1

      See identical proteins and their annotated locations for NP_444253.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the full-length transcript and encodes the full-length nonmuscle isoform.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS46896.1
      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000353452.3, ENST00000360304.8
      Conserved Domains (5) summary
      cd05762
      Location:12381335
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18091899
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14611719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    3. NM_053026.4NP_444254.3  myosin light chain kinase, smooth muscle isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) does not utilize exon 11, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS43141.1
      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000320622.5, ENST00000346322.9
      Conserved Domains (5) summary
      cd05762
      Location:11691266
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:12621354
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17401830
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:13921650
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    4. NM_053027.4NP_444255.3  myosin light chain kinase, smooth muscle isoform 3A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3A) does not utilize exon 30, compared to variant 1, resulting in a shorter protein (isoform 3A), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      Consensus CDS
      CCDS3023.1
      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000354004.3, ENST00000360772.7
      Conserved Domains (9) summary
      cd00096
      Location:640709
      Ig; Immunoglobulin domain
      cd05762
      Location:12381335
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:17711838
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17581848
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:14641668
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:724809
      Ig; Immunoglobulin domain
      cl21453
      Location:14611668
      PKc_like; Protein Kinases, catalytic domain
    5. NM_053028.4NP_444256.3  myosin light chain kinase, smooth muscle isoform 3B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3B) does not utilize exons 11 and 30, compared to variant 1, resulting in a shorter protein (isoform 3B), compared to isoform 1.
      Source sequence(s)
      AC020634, AC023165, AC117381, AY339601, BC064420, BC064695, U48959
      UniProtKB/Swiss-Prot
      Q15746
      Conserved Domains (9) summary
      cd00096
      Location:571640
      Ig; Immunoglobulin domain
      cd05762
      Location:11691266
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:17021769
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:12621354
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:16891779
      I-set; Immunoglobulin I-set domain
      pfam00069
      Location:13951599
      Pkinase; Protein kinase domain
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:655740
      Ig; Immunoglobulin domain
      cl21453
      Location:13921599
      PKc_like; Protein Kinases, catalytic domain
    6. NM_053031.4NP_444259.1  myosin light chain kinase, smooth muscle isoform 7

      See identical proteins and their annotated locations for NP_444259.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes the shorter isoform of kinase related protein, telokin. The first exon corresponds to intron 30 and the remainder of the transcript corresponds to the last two exons of the gene. It is shorter than variant 8 by one codon at the splicing junction between the first two exons.
      Source sequence(s)
      AC023165, BC064420, BC113458, DB016380
      Consensus CDS
      CCDS58849.1
      UniProtKB/Swiss-Prot
      Q15746
      UniProtKB/TrEMBL
      Q05B97
      Related
      ENSP00000463691.1, ENST00000578202.1
      Conserved Domains (1) summary
      pfam07679
      Location:48138
      I-set; Immunoglobulin I-set domain
    7. NM_053032.4NP_444260.1  myosin light chain kinase, smooth muscle isoform 8

      See identical proteins and their annotated locations for NP_444260.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes the longer isoform of kinase related protein, telokin. It is longer than variant 7 by one codon at the splicing junction between the first two exons.
      Source sequence(s)
      AC023165, BC064420, BC113456, DB016380
      Consensus CDS
      CCDS46897.1
      UniProtKB/Swiss-Prot
      Q15746
      UniProtKB/TrEMBL
      Q05B98
      Related
      ENSP00000428967.1, ENST00000418370.6
      Conserved Domains (1) summary
      cd20973
      Location:52139
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      123610049..123884332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006473.1XP_016861962.1  myosin light chain kinase, smooth muscle isoform X11

      UniProtKB/Swiss-Prot
      Q15746
      Conserved Domains (1) summary
      pfam07679
      Location:48138
      I-set; Immunoglobulin I-set domain
    2. XM_017006472.2XP_016861961.1  myosin light chain kinase, smooth muscle isoform X10

      UniProtKB/Swiss-Prot
      Q15746
      Related
      ENSP00000462118.1, ENST00000583087.5
      Conserved Domains (1) summary
      cd20973
      Location:52139
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
    3. XM_017006469.2XP_016861958.1  myosin light chain kinase, smooth muscle isoform X7

      UniProtKB/Swiss-Prot
      Q15746
    4. XM_017006471.2XP_016861960.1  myosin light chain kinase, smooth muscle isoform X9

      UniProtKB/Swiss-Prot
      Q15746
      Conserved Domains (4) summary
      cd00063
      Location:131223
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05762
      Location:37135
      IgI_8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar protein; member of the I-set of IgSF domains
      cd20973
      Location:612699
      IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
      cl21453
      Location:261519
      PKc_like; Protein Kinases, catalytic domain
    5. XM_017006470.2XP_016861959.1  myosin light chain kinase, smooth muscle isoform X8

    6. XM_024453533.1XP_024309301.1  myosin light chain kinase, smooth muscle isoform X3

      Conserved Domains (5) summary
      cd05762
      Location:12381335
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18091899
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14611719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    7. XM_024453535.1XP_024309303.1  myosin light chain kinase, smooth muscle isoform X6

      Conserved Domains (5) summary
      cd05762
      Location:11691266
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:12621354
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17401830
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:13921650
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    8. XM_024453534.1XP_024309302.1  myosin light chain kinase, smooth muscle isoform X5

      Conserved Domains (5) summary
      cd05762
      Location:11791276
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:12721364
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17501840
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14021660
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:261422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    9. XM_024453532.1XP_024309300.1  myosin light chain kinase, smooth muscle isoform X1

      Conserved Domains (5) summary
      cd05762
      Location:12481345
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:13411433
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18191909
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14711729
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:261422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    10. XM_024453536.1XP_024309304.1  myosin light chain kinase, smooth muscle isoform X3

      Conserved Domains (5) summary
      cd05762
      Location:12381335
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18091899
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14611719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    11. XM_024453537.1XP_024309305.1  myosin light chain kinase, smooth muscle isoform X3

      Conserved Domains (5) summary
      cd05762
      Location:12381335
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:13311423
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18091899
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14611719
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:251412
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    12. XM_011512861.3XP_011511163.2  myosin light chain kinase, smooth muscle isoform X4

      Conserved Domains (5) summary
      cd05762
      Location:12481345
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:13411433
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17511841
      I-set; Immunoglobulin I-set domain
      pfam16620
      Location:261422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl21453
      Location:14831661
      PKc_like; Protein Kinases, catalytic domain
    13. XM_011512860.3XP_011511162.2  myosin light chain kinase, smooth muscle isoform X2

      Conserved Domains (5) summary
      cd05762
      Location:12481345
      Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
      cd00063
      Location:13411433
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18181908
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14711729
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam16620
      Location:261422
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005965.3: Suppressed sequence

      Description
      NM_005965.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_053029.2: Suppressed sequence

      Description
      NM_053029.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    3. NM_053030.2: Suppressed sequence

      Description
      NM_053030.2: This RefSeq was permanently suppressed because there was insufficient support for the transcript and the CDS was partial.
    Support Center