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    MSN moesin [ Homo sapiens (human) ]

    Gene ID: 4478, updated on 9-Dec-2018

    Summary

    Official Symbol
    MSNprovided by HGNC
    Official Full Name
    moesinprovided by HGNC
    Primary source
    HGNC:HGNC:7373
    See related
    Ensembl:ENSG00000147065 MIM:309845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEL70; IMD50
    Summary
    Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 147.3), appendix (RPKM 142.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See MSN in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (65588382..65741931)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64808257..64961793)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene LAS1 like, ribosome biogenesis factor Neighboring gene FERM domain containing 8 pseudogene 1 Neighboring gene uncharacterized LOC107985679 Neighboring gene Nanog homeobox pseudogene 9 Neighboring gene eukaryotic translation termination factor 1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of moesin (MSN) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Association and clustering of CD4-CXCR4 induced by HIV-1 gp120 requires moesin-mediated anchoring of actin in the plasma membrane PubMed
    env Interaction of the X4-tropic protein HIV-1 gp120 with CD4 augments ezrin and moesin phosphorylation in human permissive T cells, thereby regulating ezrin-moesin activation PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 induces CD95-mediated apoptosis, CD95/ERM protein (ezrin, radixin, moesin) colocalization and stable ezrin phosphorylation PubMed
    env Ezrin and moesin are structural proteins that bind to the cellular membrane and interact with HIV-1 gp120/gp160 in CD4- and Gal-C-negative brain cells; ezrin and moesin play a role as gp120/gp160 binding proteins during the uptake of HIV PubMed
    Pr55(Gag) gag HIV-1 Gag co-localizes with ezrin-radixin-moesin proteins at polarized HIV-1 assembly sites in human T cells PubMed
    gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
    Vpr vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with moesin (MSN) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
      AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Glial Cell Differentiation, organism-specific biosystem (from WikiPathways)
      Glial Cell Differentiation, organism-specific biosystem
      Glial Cell Differentiation
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Plasma membrane estrogen receptor signaling, organism-specific biosystem
      Plasma membrane estrogen receptor signaling
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
      Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell aggregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to testosterone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of endothelial barrier IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immunological synapse formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-12-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    leukocyte cell-cell adhesion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    leukocyte migration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    membrane to membrane docking IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cellular protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of early endosome to late endosome transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of podosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to early endosome IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lymphocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of organelle assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    blood microparticle HDA PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm HDA PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular space HDA PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion HDA PubMed 
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    invadopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus HDA PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    uropod IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle HDA PubMed 

    General protein information

    Preferred Names
    moesin
    Names
    epididymis luminal protein 70
    membrane-organizing extension spike protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012516.1 RefSeqGene

      Range
      5001..79283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002444.3NP_002435.1  moesin

      See identical proteins and their annotated locations for NP_002435.1

      Status: REVIEWED

      Source sequence(s)
      BC017293, CN386296, M69066
      Consensus CDS
      CCDS14382.1
      UniProtKB/Swiss-Prot
      P26038
      UniProtKB/TrEMBL
      V9HWC0
      Related
      ENSP00000353408.5, ENST00000360270.6
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347577
      ERM; Ezrin/radixin/moesin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      65588382..65741931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262269.2XP_005262326.1  moesin isoform X2

      See identical proteins and their annotated locations for XP_005262326.1

      Conserved Domains (3) summary
      smart00295
      Location:8207
      B41; Band 4.1 homologues
      cd13194
      Location:201297
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:348578
      ERM; Ezrin/radixin/moesin family
    2. XM_011530959.1XP_011529261.1  moesin isoform X1

      Conserved Domains (6) summary
      smart00295
      Location:40239
      B41; Band 4.1 homologues
      cd13194
      Location:233329
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:124239
      FERM_M; FERM central domain
      pfam00769
      Location:380610
      ERM; Ezrin/radixin/moesin family
      pfam07851
      Location:416497
      TMPIT; TMPIT-like protein
      pfam09379
      Location:42104
      FERM_N; FERM N-terminal domain
    3. XM_017029546.1XP_016885035.1  moesin isoform X3

      Conserved Domains (6) summary
      smart00295
      Location:1195
      B41; Band 4.1 homologues
      cd13194
      Location:189285
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:80195
      FERM_M; FERM central domain
      pfam00769
      Location:336566
      ERM; Ezrin/radixin/moesin family
      pfam07851
      Location:372453
      TMPIT; TMPIT-like protein
      pfam09379
      Location:260
      FERM_N; FERM N-terminal domain
    4. XM_017029545.1XP_016885034.1  moesin isoform X3

      Conserved Domains (6) summary
      smart00295
      Location:1195
      B41; Band 4.1 homologues
      cd13194
      Location:189285
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:80195
      FERM_M; FERM central domain
      pfam00769
      Location:336566
      ERM; Ezrin/radixin/moesin family
      pfam07851
      Location:372453
      TMPIT; TMPIT-like protein
      pfam09379
      Location:260
      FERM_N; FERM N-terminal domain
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