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    MSN moesin [ Homo sapiens (human) ]

    Gene ID: 4478, updated on 17-Oct-2021

    Summary

    Official Symbol
    MSNprovided by HGNC
    Official Full Name
    moesinprovided by HGNC
    Primary source
    HGNC:HGNC:7373
    See related
    Ensembl:ENSG00000147065 MIM:309845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEL70; IMD50
    Summary
    Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 147.3), appendix (RPKM 142.6) and 24 other tissues See more
    Orthologs
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    Genomic context

    See MSN in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (65588382..65741931)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64887521..64961793)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene FERM domain containing 8 pseudogene 1 Neighboring gene uncharacterized LOC107985679 Neighboring gene Nanog homeobox pseudogene 9 Neighboring gene eukaryotic translation termination factor 1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of moesin (MSN) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Association and clustering of CD4-CXCR4 induced by HIV-1 gp120 requires moesin-mediated anchoring of actin in the plasma membrane PubMed
    env Interaction of the X4-tropic protein HIV-1 gp120 with CD4 augments ezrin and moesin phosphorylation in human permissive T cells, thereby regulating ezrin-moesin activation PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 induces CD95-mediated apoptosis, CD95/ERM protein (ezrin, radixin, moesin) colocalization and stable ezrin phosphorylation PubMed
    env Ezrin and moesin are structural proteins that bind to the cellular membrane and interact with HIV-1 gp120/gp160 in CD4- and Gal-C-negative brain cells; ezrin and moesin play a role as gp120/gp160 binding proteins during the uptake of HIV PubMed
    Pr55(Gag) gag HIV-1 Gag co-localizes with ezrin-radixin-moesin proteins at polarized HIV-1 assembly sites in human T cells PubMed
    gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
    Vpr vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with moesin (MSN) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell aggregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to testosterone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of endothelial barrier IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immunological synapse formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukocyte cell-cell adhesion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in leukocyte migration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in membrane to membrane docking IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of cellular protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of early endosome to late endosome transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of podosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to early endosome IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lymphocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of organelle assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in blood microparticle HDA PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion HDA PubMed 
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in uropod IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle HDA PubMed 

    General protein information

    Preferred Names
    moesin
    Names
    epididymis luminal protein 70
    membrane-organizing extension spike protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012516.1 RefSeqGene

      Range
      5011..79283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002444.3NP_002435.1  moesin

      See identical proteins and their annotated locations for NP_002435.1

      Status: REVIEWED

      Source sequence(s)
      BC017293, CN386296, M69066
      Consensus CDS
      CCDS14382.1
      UniProtKB/Swiss-Prot
      P26038
      UniProtKB/TrEMBL
      V9HWC0
      Related
      ENSP00000353408.5, ENST00000360270.7
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347577
      ERM; Ezrin/radixin/moesin family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      65588382..65741931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262269.2XP_005262326.1  moesin isoform X2

      See identical proteins and their annotated locations for XP_005262326.1

      Conserved Domains (3) summary
      smart00295
      Location:8207
      B41; Band 4.1 homologues
      cd13194
      Location:201297
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:348578
      ERM; Ezrin/radixin/moesin family
    2. XM_011530959.1XP_011529261.1  moesin isoform X1

      Conserved Domains (6) summary
      smart00295
      Location:40239
      B41; Band 4.1 homologues
      cd13194
      Location:233329
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:124239
      FERM_M; FERM central domain
      pfam00769
      Location:380610
      ERM; Ezrin/radixin/moesin family
      pfam07851
      Location:416497
      TMPIT; TMPIT-like protein
      pfam09379
      Location:42104
      FERM_N; FERM N-terminal domain
    3. XM_017029546.1XP_016885035.1  moesin isoform X3

      Conserved Domains (3) summary
      smart00295
      Location:1195
      B41; Band 4.1 homologues
      cd13194
      Location:189285
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:336566
      ERM; Ezrin/radixin/moesin family
    4. XM_017029545.1XP_016885034.1  moesin isoform X3

      Conserved Domains (3) summary
      smart00295
      Location:1195
      B41; Band 4.1 homologues
      cd13194
      Location:189285
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:336566
      ERM; Ezrin/radixin/moesin family
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