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    RGS21 regulator of G protein signaling 21 [ Homo sapiens (human) ]

    Gene ID: 431704, updated on 5-Mar-2024

    Summary

    Official Symbol
    RGS21provided by HGNC
    Official Full Name
    regulator of G protein signaling 21provided by HGNC
    Primary source
    HGNC:HGNC:26839
    See related
    Ensembl:ENSG00000253148 MIM:612407; AllianceGenome:HGNC:26839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See RGS21 in Genome Data Viewer
    Location:
    1q31.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (192316992..192367285)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (191663986..191714313)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192286122..192336415)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:192220431-192220932 Neighboring gene ATP binding cassette subfamily E member 1 pseudogene Neighboring gene uncharacterized LOC124904473 Neighboring gene uncharacterized LOC124904472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:192469395-192469976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:192469977-192470558 Neighboring gene uncharacterized LOC105371664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2263 Neighboring gene regulator of G protein signaling 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of bitter taste IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of sweet taste IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of umami taste IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 21
    Names
    regulator of G-protein signalling 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039152.3NP_001034241.1  regulator of G-protein signaling 21

      See identical proteins and their annotated locations for NP_001034241.1

      Status: VALIDATED

      Source sequence(s)
      AL357566, AL390957, AY643711
      Consensus CDS
      CCDS41448.1
      UniProtKB/Swiss-Prot
      Q2M5E4
      Related
      ENSP00000428343.1, ENST00000417209.2
      Conserved Domains (1) summary
      cd08723
      Location:25135
      RGS_RGS21; Regulator of G protein signaling (RGS) domain found in the RGS21 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      192316992..192367285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      191663986..191714313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)