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    MAP3K11 mitogen-activated protein kinase kinase kinase 11 [ Homo sapiens (human) ]

    Gene ID: 4296, updated on 5-Sep-2021

    Summary

    Official Symbol
    MAP3K11provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 11provided by HGNC
    Primary source
    HGNC:HGNC:6850
    See related
    Ensembl:ENSG00000173327 MIM:600050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MLK3; PTK1; SPRK; MLK-3; MEKK11
    Summary
    The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 25.3), fat (RPKM 22.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MAP3K11 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65597755..65614221, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65365228..65381692, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene EH domain binding protein 1 like 1 Neighboring gene potassium two pore domain channel subfamily K member 7 Neighboring gene pecanex 3 Neighboring gene microRNA 4690 Neighboring gene signal-induced proliferation-associated 1 Neighboring gene microRNA 4489

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of neurons with HIV-1 gp120 in culture produces apoptotic neuronal death through the mixed lineage kinase 3 (MLK3) signaling pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC17114

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell cycle G1/S phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 11
    Names
    SH3 domain-containing proline-rich kinase
    mixed lineage kinase 3
    protein-tyrosine kinase PTK1
    src-homology 3 domain-containing proline-rich kinase
    NP_002410.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002419.4NP_002410.1  mitogen-activated protein kinase kinase kinase 11

      See identical proteins and their annotated locations for NP_002410.1

      Status: REVIEWED

      Source sequence(s)
      L32976, U07747
      Consensus CDS
      CCDS8107.1
      UniProtKB/Swiss-Prot
      Q16584
      UniProtKB/TrEMBL
      A0A024R5E6
      Related
      ENSP00000309597.3, ENST00000309100.8
      Conserved Domains (3) summary
      cd12059
      Location:45102
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      smart00221
      Location:117376
      STYKc; Protein kinase; unclassified specificity
      cd14147
      Location:113379
      STKc_MLK3; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      65597755..65614221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_428915.2 RNA Sequence

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