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    MAP3K10 mitogen-activated protein kinase kinase kinase 10 [ Homo sapiens (human) ]

    Gene ID: 4294, updated on 7-Dec-2018

    Summary

    Official Symbol
    MAP3K10provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 10provided by HGNC
    Primary source
    HGNC:HGNC:6849
    See related
    Ensembl:ENSG00000130758 MIM:600137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST; MLK2; MEKK10
    Summary
    The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues See more
    Orthologs

    Genomic context

    See MAP3K10 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (40191657..40215575)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40697504..40721487)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 780A Neighboring gene vomeronasal 1 receptor 96 pseudogene Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene cyclin N-terminal domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    JUN kinase kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    JNK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of JNKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 10
    Names
    MKN28 derived nonreceptor_type serine/threonine kinase
    MKN28 kinase
    mixed lineage kinase 2
    protein kinase MST
    NP_002437.2
    XP_006723286.1
    XP_011525283.1
    XP_011525284.1
    XP_024307287.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002446.4NP_002437.2  mitogen-activated protein kinase kinase kinase 10

      See identical proteins and their annotated locations for NP_002437.2

      Status: REVIEWED

      Source sequence(s)
      AC011496, BF594729, BU633407, X90846, Z48615
      Consensus CDS
      CCDS12549.1
      UniProtKB/Swiss-Prot
      Q02779
      Related
      ENSP00000253055.2, ENST00000253055.7
      Conserved Domains (3) summary
      smart00219
      Location:98357
      TyrKc; Tyrosine kinase, catalytic domain
      cd12059
      Location:2076
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14148
      Location:103360
      STKc_MLK2; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      40191657..40215575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526981.2XP_011525283.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

      Conserved Domains (3) summary
      smart00219
      Location:98365
      TyrKc; Tyrosine kinase, catalytic domain
      cd12059
      Location:2076
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103368
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011526982.3XP_011525284.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

      Conserved Domains (3) summary
      smart00219
      Location:98365
      TyrKc; Tyrosine kinase, catalytic domain
      cd12059
      Location:2076
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cl21453
      Location:103368
      PKc_like; Protein Kinases, catalytic domain
    3. XM_024451519.1XP_024307287.1  mitogen-activated protein kinase kinase kinase 10 isoform X3

      Conserved Domains (3) summary
      cl21453
      Location:326
      PKc_like; Protein Kinases, catalytic domain
      cl25602
      Location:37121
      DUF3552; Domain of unknown function (DUF3552)
      cl26464
      Location:254597
      Atrophin-1; Atrophin-1 family
    4. XM_006723223.3XP_006723286.1  mitogen-activated protein kinase kinase kinase 10 isoform X4

      Conserved Domains (1) summary
      PHA03247
      Location:158501
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_001753691.1 RNA Sequence

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