MAT2A methionine adenosyltransferase 2A [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAT2Aprovided by HGNC
Official Full Name: methionine adenosyltransferase 2Aprovided by HGNC
Primary source: HGNC:HGNC:6904
See related: Ensembl:ENSG00000168906 MIM:601468; AllianceGenome:HGNC:6904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MATA2; MATII; SAMS2
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
Expression: Ubiquitous expression in thyroid (RPKM 234.0), adrenal (RPKM 141.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p11.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (85539168..85545281)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (85541227..85547340)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (85766291..85772404)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.
Title: Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.
Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro.
Title: Expression of vimentin, TPI and MAT2A in human dermal microvascular endothelial cells during angiogenesis in vitro.
Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.
Title: Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.
MAT2A-Mediated S-Adenosylmethionine Level in CD4(+) T Cells Regulates HIV-1 Latent Infection.
Title: MAT2A-Mediated S-Adenosylmethionine Level in CD4(+) T Cells Regulates HIV-1 Latent Infection.
Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.
Title: Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.
Title: Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.
Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development.
Title: Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development.
Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.
Title: Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.
Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer.
Title: Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer.
MALAT1 Inhibits Proliferation of HPV16-Positive Cervical Cancer by Sponging miR-485-5p to Promote Expression of MAT2A.
Title: MALAT1 Inhibits Proliferation of HPV16-Positive Cervical Cancer by Sponging miR-485-5p to Promote Expression of MAT2A.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interaction	Pubs
Knockdown of methionine adenosyltransferase II, alpha (MAT2A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD05697 (e-PCR)
- UniSTS:286759

D3S3930 (e-PCR)
- UniSTS:68704

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small molecule binding	EXP Inferred from Experiment more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to methionine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to methionine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in protein complex oligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein hexamerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to lysosome	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein-containing complex localization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of methionine adenosyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of methionine adenosyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of methionine adenosyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of methionine adenosyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: S-adenosylmethionine synthase isoform type-2

Names: MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; testicular tissue protein Li 121

NP_005902.1

EC 2.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.