TACSTD2 tumor associated calcium signal transducer 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TACSTD2provided by HGNC
Official Full Name: tumor associated calcium signal transducer 2provided by HGNC
Primary source: HGNC:HGNC:11530
See related: Ensembl:ENSG00000184292 MIM:137290; AllianceGenome:HGNC:11530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
Summary: This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
Orthologs: mouse all
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Genomic context

Location:: 1p32.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (58575433..58577252, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (58453397..58455216, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (59041105..59042924, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis.
Title: TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis.
TROP2 in colorectal carcinoma: associations with histopathology, molecular phenotype, and patient prognosis.
Title: TROP2 in colorectal carcinoma: associations with histopathology, molecular phenotype, and patient prognosis.
Trop-2 expression and the tumor immune microenvironment in cervical cancer.
Title: Trop-2 expression and the tumor immune microenvironment in cervical cancer.
Unveiling the placental secrets: Exploring histopathological changes and TROP2 expression in intrahepatic cholestasis of pregnancy.
Title: Unveiling the placental secrets: Exploring histopathological changes and TROP2 expression in intrahepatic cholestasis of pregnancy.
TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression.
Title: TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression.
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
Title: Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
Title: Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
Title: TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non-Small Cell Lung Cancer.
DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
Title: DNA demethylation and tri-methylation of H3K4 at the TACSTD2 promoter are complementary players for TROP2 regulation in colorectal cancer cells.
Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.
Title: Trop-2 Is Highly Expressed in Early Luminal-Like Breast Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (135)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Gelatinous droplike corneal dystrophy MedGen: C0339273 OMIM: 204870 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G62083 (e-PCR)
- UniSTS:139084

RH36205 (e-PCR)
- UniSTS:3158

D1S2398 (e-PCR)
- UniSTS:6293

RH47574 (e-PCR)
- UniSTS:70050

RH67868 (e-PCR)
- UniSTS:65248

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell motility	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stem cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info
involved_in visual perception	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor-associated calcium signal transducer 2

Names: 40kD glycoprotein, identified by monoclonal antibody GA733; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; epithelial glycoprotein-1; gastrointestinal tumor-associated antigen GA7331; membrane component, chromosome 1, surface marker 1; pancreatic carcinoma marker protein GA733-1; pancreatic carcinoma marker protein GA7331; trophoblast cell surface antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016237.1 RefSeqGene

Range

5243..7062

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002353.3 → NP_002344.2 tumor-associated calcium signal transducer 2 precursor

See identical proteins and their annotated locations for NP_002344.2

Status: REVIEWED

Source sequence(s)

AI201870, AW052118, BM765888, CD722224, CV027795

Consensus CDS

CCDS609.1

UniProtKB/Swiss-Prot

P09758, Q15658, Q6FG48, Q7Z7Q4, Q96QD2

UniProtKB/TrEMBL

C5IX07

Related

ENSP00000360269.2, ENST00000371225.4

Conserved Domains (1) summary

cd00191
Location:72 → 145

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases