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    LY75 lymphocyte antigen 75 [ Homo sapiens (human) ]

    Gene ID: 4065, updated on 13-Feb-2019

    Summary

    Official Symbol
    LY75provided by HGNC
    Official Full Name
    lymphocyte antigen 75provided by HGNC
    Primary source
    HGNC:HGNC:6729
    See related
    Ensembl:ENSG00000054219 MIM:604524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD205; LY-75; CLEC13B; DEC-205; GP200-MR6
    Expression
    Broad expression in lymph node (RPKM 17.2), appendix (RPKM 13.2) and 17 other tissues See more
    Orthologs

    Genomic context

    See LY75 in Genome Data Viewer
    Location:
    2q24.2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (159803355..159904756, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160659866..160761267, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene LY75-CD302 readthrough Neighboring gene CD302 molecule Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717 Neighboring gene integrin subunit beta 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LY75 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with LY75; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of lymphocyte antigen 75 (LY75) in primary human brain microvascular endothelial cells PubMed
    capsid gag When introduced the HIV p24 gag protein into a mAb that targets DEC-205/CD205, an endocytic receptor of DCs, low doses of alphaDEC-gag, but not control Ig-gag, stimulates proliferation and IFN-gamma production by CD8+ T cells from HIV-infected donors PubMed

    Go to the HIV-1, Human Interaction Database

    General gene information

    Markers

    Readthrough LY75-CD302

    Readthrough gene: LY75-CD302, Included gene: CD302

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    lymphocyte antigen 75
    Names
    C-type lectin domain family 13 member B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002349.4NP_002340.2  lymphocyte antigen 75 precursor

      See identical proteins and their annotated locations for NP_002340.2

      Status: VALIDATED

      Source sequence(s)
      AA279177, AB208915, AF011333, AU099700, DB135177, DB146492, DB150194
      Consensus CDS
      CCDS2211.1
      UniProtKB/Swiss-Prot
      O60449
      UniProtKB/TrEMBL
      Q59H44
      Related
      ENSP00000263636.4, ENST00000263636.4
      Conserved Domains (5) summary
      smart00059
      Location:162209
      FN2; Fibronectin type 2 domain
      cd00037
      Location:11151222
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:361486
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:38112
      RICIN; Ricin-type beta-trefoil
      cd00161
      Location:40125
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      159803355..159904756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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