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    LIPE lipase E, hormone sensitive type [ Homo sapiens (human) ]

    Gene ID: 3991, updated on 5-Aug-2018

    Summary

    Official Symbol
    LIPEprovided by HGNC
    Official Full Name
    lipase E, hormone sensitive typeprovided by HGNC
    Primary source
    HGNC:HGNC:6621
    See related
    Ensembl:ENSG00000079435 MIM:151750; Vega:OTTHUMG00000182814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSL; LHS; AOMS4; FPLD6
    Summary
    The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in fat (RPKM 187.4) and testis (RPKM 12.7) See more
    Orthologs

    Genomic context

    See LIPE in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (42401507..42427426, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42905664..42931578, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 8 Neighboring gene microRNA 8077 Neighboring gene uncharacterized LOC101930071 Neighboring gene LIPE antisense RNA 1 Neighboring gene cornifelin Neighboring gene C-X-C motif chemokine ligand 17 Neighboring gene RNA, U4 small nuclear 60, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
      AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Fatty Acid Beta Oxidation, organism-specific biosystem (from WikiPathways)
      Fatty Acid Beta Oxidation, organism-specific biosystemComplete fatty acid beta-oxidation pathway for saturated and unsaturated fatty acids, developed and curated internally by BiGCaT Bioinformatics. This pathway was previously split into three parts p...
    • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
      Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
      Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
    • Triacylglyceride Synthesis, organism-specific biosystem (from WikiPathways)
      Triacylglyceride Synthesis, organism-specific biosystem
      Triacylglyceride Synthesis
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • triacylglycerol degradation, organism-specific biosystem (from BIOCYC)
      triacylglycerol degradation, organism-specific biosystem
      triacylglycerol degradation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hormone-sensitive lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    serine hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    diacylglycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-chain fatty acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    caveola IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    hormone-sensitive lipase
    Names
    hormone-sensitive lipase testicular isoform
    lipase, hormone-sensitive
    NP_005348.2
    XP_005258994.1
    XP_005258995.1
    XP_005258996.2
    XP_005258997.1
    XP_006723281.1
    XP_016882299.1
    XP_024307282.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034246.1 RefSeqGene

      Range
      5001..30920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005357.3NP_005348.2  hormone-sensitive lipase

      See identical proteins and their annotated locations for NP_005348.2

      Status: REVIEWED

      Source sequence(s)
      AK292482, BC070041
      Consensus CDS
      CCDS12607.1
      UniProtKB/Swiss-Prot
      Q05469
      UniProtKB/TrEMBL
      A8K8W7
      Related
      ENSP00000244289.3, OTTHUMP00000270276, ENST00000244289.8, OTTHUMT00000463861
      Conserved Domains (4) summary
      COG0657
      Location:637790
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:307615
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      pfam16228
      Location:30134
      DUF4887; Domain of unknown function (DUF4887)
      cl21494
      Location:647795
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      42401507..42427426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258937.3XP_005258994.1  hormone-sensitive lipase isoform X1

      Conserved Domains (4) summary
      COG0657
      Location:637975
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:307615
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      pfam16228
      Location:30134
      DUF4887; Domain of unknown function (DUF4887)
      cl21494
      Location:647952
      Abhydrolase; alpha/beta hydrolases
    2. XM_005258938.5XP_005258995.1  hormone-sensitive lipase isoform X3

      Conserved Domains (3) summary
      COG0657
      Location:382535
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:52360
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:392540
      Abhydrolase; alpha/beta hydrolases
    3. XM_024451514.1XP_024307282.1  hormone-sensitive lipase isoform X5

      Conserved Domains (2) summary
      pfam06350
      Location:52360
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:392697
      Abhydrolase; alpha/beta hydrolases
    4. XM_006723218.3XP_006723281.1  hormone-sensitive lipase isoform X4

      See identical proteins and their annotated locations for XP_006723281.1

      UniProtKB/Swiss-Prot
      Q05469
      Conserved Domains (3) summary
      COG0657
      Location:336489
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346494
      Abhydrolase; alpha/beta hydrolases
    5. XM_005258939.3XP_005258996.2  hormone-sensitive lipase isoform X2

      Conserved Domains (3) summary
      COG0657
      Location:399552
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:69377
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:409557
      Abhydrolase; alpha/beta hydrolases
    6. XM_005258940.3XP_005258997.1  hormone-sensitive lipase isoform X4

      See identical proteins and their annotated locations for XP_005258997.1

      UniProtKB/Swiss-Prot
      Q05469
      Conserved Domains (3) summary
      COG0657
      Location:336489
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346494
      Abhydrolase; alpha/beta hydrolases
    7. XM_017026810.1XP_016882299.1  hormone-sensitive lipase isoform X4

      UniProtKB/Swiss-Prot
      Q05469
      Conserved Domains (3) summary
      COG0657
      Location:336489
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346494
      Abhydrolase; alpha/beta hydrolases
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