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    ARHGDIG Rho GDP dissociation inhibitor gamma [ Homo sapiens (human) ]

    Gene ID: 398, updated on 21-Dec-2019

    Summary

    Official Symbol
    ARHGDIGprovided by HGNC
    Official Full Name
    Rho GDP dissociation inhibitor gammaprovided by HGNC
    Primary source
    HGNC:HGNC:680
    See related
    Ensembl:ENSG00000242173 MIM:602844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RHOGDI-3
    Summary
    The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
    Expression
    Biased expression in brain (RPKM 34.7), duodenum (RPKM 7.8) and 4 other tissues See more
    Orthologs

    Genomic context

    See ARHGDIG in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (280591..283010)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (330606..333003)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 4 open reading frame 46 pseudogene Neighboring gene family with sequence similarity 234 member A Neighboring gene regulator of G protein signaling 11 Neighboring gene protein disulfide isomerase family A member 2 Neighboring gene axin 1 Neighboring gene Sharpr-MPRA regulatory region 4309

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: PDIA2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Rac GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rho GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    blastocyst hatching IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    rho GDP-dissociation inhibitor 3
    Names
    Rho GDP dissociation inhibitor (GDI) gamma
    RhoGDI gamma
    rho GDI 3
    rho-GDI gamma

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001176.4NP_001167.2  rho GDP-dissociation inhibitor 3

      See identical proteins and their annotated locations for NP_001167.2

      Status: VALIDATED

      Source sequence(s)
      BC047699, BM662457, Z69667
      Consensus CDS
      CCDS10404.1
      UniProtKB/Swiss-Prot
      Q99819
      UniProtKB/TrEMBL
      F1T0H7
      Related
      ENSP00000219409.3, ENST00000219409.8
      Conserved Domains (1) summary
      pfam02115
      Location:42222
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      280591..283010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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