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    ARHGDIB Rho GDP dissociation inhibitor beta [ Homo sapiens (human) ]

    Gene ID: 397, updated on 2-Oct-2018

    Summary

    Official Symbol
    ARHGDIBprovided by HGNC
    Official Full Name
    Rho GDP dissociation inhibitor betaprovided by HGNC
    Primary source
    HGNC:HGNC:679
    See related
    Ensembl:ENSG00000111348 MIM:602843; Vega:OTTHUMG00000168742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2
    Summary
    Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
    Expression
    Broad expression in bone marrow (RPKM 324.5), lymph node (RPKM 244.8) and 19 other tissues See more
    Orthologs

    Genomic context

    See ARHGDIB in Genome Data Viewer
    Location:
    12p12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (14942015..14961770, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (15094949..15114562, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27 Neighboring gene uncharacterized LOC105369670 Neighboring gene phosphodiesterase 6H Neighboring gene long intergenic non-protein coding RNA 1489

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr The proteomic assay from Vpr-expressing HTLV-1 transformed cells reveals apoptosis related protein changes, such as CASP3 activity indicator proteins (vimentin and Rho GDP-dissociation inhibitor 2) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystem (from WikiPathways)
      Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Rac GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rac GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rho GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    rho GDP-dissociation inhibitor 2
    Names
    Rho GDI 2
    Rho GDP dissociation inhibitor (GDI) beta
    rho-GDI beta

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001175.6NP_001166.3  rho GDP-dissociation inhibitor 2

      See identical proteins and their annotated locations for NP_001166.3

      Status: VALIDATED

      Source sequence(s)
      BC009200, BI762648, BM849963, BP355037, BY996333
      Consensus CDS
      CCDS8671.1
      UniProtKB/Swiss-Prot
      P52566
      UniProtKB/TrEMBL
      A0A024RAS5
      Related
      ENSP00000228945.4, OTTHUMP00000239340, ENST00000228945.8, OTTHUMT00000400871
      Conserved Domains (1) summary
      pfam02115
      Location:23198
      Rho_GDI; RHO protein GDP dissociation inhibitor
    2. NM_001321420.1NP_001308349.1  rho GDP-dissociation inhibitor 2

      Status: VALIDATED

      Source sequence(s)
      BC009200, BG390701, BI762648, BP355037, BQ213418
      Consensus CDS
      CCDS8671.1
      UniProtKB/Swiss-Prot
      P52566
      UniProtKB/TrEMBL
      A0A024RAS5
      Related
      ENSP00000440560.1, OTTHUMP00000239343, ENST00000541546.5, OTTHUMT00000400875
      Conserved Domains (1) summary
      pfam02115
      Location:23198
      Rho_GDI; RHO protein GDP dissociation inhibitor
    3. NM_001321421.1NP_001308350.1  rho GDP-dissociation inhibitor 2

      Status: VALIDATED

      Source sequence(s)
      AC007655, AV685495, AV717900, BC009200, BM849963, BY996333
      Consensus CDS
      CCDS8671.1
      UniProtKB/Swiss-Prot
      P52566
      UniProtKB/TrEMBL
      A0A024RAS5
      Conserved Domains (1) summary
      pfam02115
      Location:23198
      Rho_GDI; RHO protein GDP dissociation inhibitor
    4. NM_001321422.1NP_001308351.1  rho GDP-dissociation inhibitor 2

      Status: VALIDATED

      Source sequence(s)
      AC007655, BC009200, BM849963, BY996333, CD385175
      Consensus CDS
      CCDS8671.1
      UniProtKB/Swiss-Prot
      P52566
      UniProtKB/TrEMBL
      A0A024RAS5
      Conserved Domains (1) summary
      pfam02115
      Location:23198
      Rho_GDI; RHO protein GDP dissociation inhibitor
    5. NM_001321423.1NP_001308352.1  rho GDP-dissociation inhibitor 2

      Status: VALIDATED

      Source sequence(s)
      BC009200, BE744996, BM849963, BY996333, CD385175
      Consensus CDS
      CCDS8671.1
      UniProtKB/Swiss-Prot
      P52566
      UniProtKB/TrEMBL
      A0A024RAS5
      Related
      ENSP00000444860.1, OTTHUMP00000239342, ENST00000541644.5, OTTHUMT00000400873
      Conserved Domains (1) summary
      pfam02115
      Location:23198
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RNA

    1. NR_135637.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC009200, BM849963, BP365648, BY996333

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      14942015..14961770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448979.1XP_024304747.1  rho GDP-dissociation inhibitor 2 isoform X1

      Conserved Domains (1) summary
      pfam02115
      Location:23198
      Rho_GDI; RHO protein GDP dissociation inhibitor
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