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    LGALS3BP galectin 3 binding protein [ Homo sapiens (human) ]

    Gene ID: 3959, updated on 17-Jun-2024

    Summary

    Official Symbol
    LGALS3BPprovided by HGNC
    Official Full Name
    galectin 3 binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:6564
    See related
    Ensembl:ENSG00000108679 MIM:600626; AllianceGenome:HGNC:6564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B
    Summary
    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 179.8), colon (RPKM 156.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See LGALS3BP in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78971255..78979923, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79866027..79877550, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76967337..76976005, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene MPRA-validated peak3021 silencer Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76869765-76870265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76874955-76875848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76875849-76876740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76877535-76878035 Neighboring gene Sharpr-MPRA regulatory region 5911/8204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9076 Neighboring gene CEP295 N-terminal like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76898462-76899062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76911943-76912638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76912639-76913334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76914785-76915760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12914 Neighboring gene Sharpr-MPRA regulatory region 14803 Neighboring gene Sharpr-MPRA regulatory region 6708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76972258-76972941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76976039-76977031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12915 Neighboring gene calcium activated nucleotidase 1 Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9078 Neighboring gene C1q and TNF related 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication is inhibited by LGALS3BP (M2BP) overexpression in 293HEK cells PubMed
    Knockdown of 90K/LGALS3BP by siRNA enhances replication and infectivity of HIV-1 in TZM-bl cells and primary macrophages PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    Envelope surface glycoprotein gp160, precursor env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    Envelope transmembrane glycoprotein gp41 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Pr55(Gag) gag HIV-1 Gag trafficking to the plasma membrane is inhibited by LGALS3BP (M2BP) and the inhibition by LGALS3BP is dependent upon vimentin PubMed
    gag HIV-1 Gag binds to LGALS3BP (M2BP) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    galectin-3-binding protein
    Names
    L3 antigen
    MAC2BP
    Mac-2-binding protein
    basement membrane autoantigen p105
    lectin galactoside-binding soluble 3-binding protein
    mac-2 BP
    serum protein 90K
    transport and golgi organization 10 homolog B
    tumor-associated antigen 90K
    NP_005558.1
    XP_054172018.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005567.4NP_005558.1  galectin-3-binding protein precursor

      See identical proteins and their annotated locations for NP_005558.1

      Status: REVIEWED

      Source sequence(s)
      BC002403, L13210
      Consensus CDS
      CCDS11759.1
      UniProtKB/Swiss-Prot
      Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
      UniProtKB/TrEMBL
      A0A0S2Z3Y1, B4DVE1
      Related
      ENSP00000262776.2, ENST00000262776.8
      Conserved Domains (3) summary
      smart00202
      Location:24124
      SR; Scavenger receptor Cys-rich
      cd18304
      Location:136247
      BTB_POZ_M2BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP)
      cd18496
      Location:256329
      BACK_LGALS3BP; BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78971255..78979923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79866027..79877550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316043.1XP_054172018.1  galectin-3-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
      UniProtKB/TrEMBL
      A0A0S2Z3Y1, B4DVE1