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    OR2A5 olfactory receptor family 2 subfamily A member 5 [ Homo sapiens (human) ]

    Gene ID: 393046, updated on 2-Oct-2018

    Summary

    Official Symbol
    OR2A5provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily A member 5provided by HGNC
    Primary source
    HGNC:HGNC:8232
    See related
    Ensembl:ENSG00000221836 Vega:OTTHUMG00000158006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR2A8; OR2A26; OR2A11P; OR7-138; OR7-141
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See OR2A5 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (144050402..144051337)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143747495..143748430)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily F member 1 (gene/pseudogene) Neighboring gene SLC16A1 pseudogene 1 Neighboring gene olfactory receptor family 6 subfamily B member 1 Neighboring gene uncharacterized LOC105375548 Neighboring gene olfactory receptor family 2 subfamily A member 25 Neighboring gene olfactory receptor family 2 subfamily A member 41 pseudogene

    Genomic regions, transcripts, and products

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Olfactory Signaling Pathway, organism-specific biosystem (from REACTOME)
      Olfactory Signaling Pathway, organism-specific biosystemMammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) th...
    • Olfactory transduction, organism-specific biosystem (from KEGG)
      Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Olfactory transduction, conserved biosystem (from KEGG)
      Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 2A5
    Names
    olfactory receptor 2A26
    olfactory receptor 2A8
    olfactory receptor 7-138/7-141
    olfactory receptor, family 2, subfamily A, member 11 pseudogene
    olfactory receptor, family 2, subfamily A, member 26
    olfactory receptor, family 2, subfamily A, member 8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012365.1NP_036497.1  olfactory receptor 2A5

      See identical proteins and their annotated locations for NP_036497.1

      Status: PROVISIONAL

      Source sequence(s)
      AC091768
      Consensus CDS
      CCDS43668.1
      UniProtKB/Swiss-Prot
      Q96R48
      UniProtKB/TrEMBL
      A0A126GW49
      Related
      ENSP00000386208.2, OTTHUMP00000212573, ENST00000408906.2, OTTHUMT00000349986
      Conserved Domains (2) summary
      pfam00001
      Location:40290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:30305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      144050402..144051337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 PATCHES

    Genomic

    1. NW_018654715.1 Reference GRCh38.p12 PATCHES

      Range
      4976..5911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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