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    LAIR2 leukocyte associated immunoglobulin like receptor 2 [ Homo sapiens (human) ]

    Gene ID: 3904, updated on 13-Feb-2019

    Summary

    Official Symbol
    LAIR2provided by HGNC
    Official Full Name
    leukocyte associated immunoglobulin like receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:6478
    See related
    Ensembl:ENSG00000167618 MIM:602993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD306
    Summary
    The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
    Expression
    Biased expression in placenta (RPKM 4.7), lymph node (RPKM 0.9) and 3 other tissues See more
    Orthologs

    Genomic context

    See LAIR2 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (54502797..54510693)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55014013..55021900)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte receptor cluster member 8 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene uncharacterized LOC105372460 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains X1 (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC71634

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    leukocyte-associated immunoglobulin-like receptor 2
    Names
    LAIR-2
    leukocyte-associated Ig-like receptor-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002288.6NP_002279.2  leukocyte-associated immunoglobulin-like receptor 2 isoform a precursor

      See identical proteins and their annotated locations for NP_002279.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC245036, AI262718, BC069366, BX106365
      Consensus CDS
      CCDS12897.1
      UniProtKB/Swiss-Prot
      Q6ISS4
      Related
      ENSP00000301202.2, ENST00000301202.6
      Conserved Domains (1) summary
      cl11960
      Location:27120
      Ig; Immunoglobulin domain
    2. NM_021270.4NP_067154.1  leukocyte-associated immunoglobulin-like receptor 2 isoform b precursor

      See identical proteins and their annotated locations for NP_067154.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b) which is shorter compared to isoform a.
      Source sequence(s)
      AC245036, AF013250, AI262718, BX106365
      Consensus CDS
      CCDS12898.1
      UniProtKB/Swiss-Prot
      Q6ISS4
      Related
      ENSP00000301203.2, ENST00000351841.2
      Conserved Domains (2) summary
      smart00410
      Location:35101
      IG_like; Immunoglobulin like
      cl11960
      Location:27120
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      54502797..54510693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526961.2XP_011525263.1  leukocyte-associated immunoglobulin-like receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_011525263.1

      Conserved Domains (2) summary
      smart00410
      Location:2389
      IG_like; Immunoglobulin like
      cl11960
      Location:15108
      Ig; Immunoglobulin domain

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      409002..416891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p12 ALT_REF_LOCI_7

      Range
      407512..415408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p12 ALT_REF_LOCI_9

      Range
      485127..493014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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