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    LAG3 lymphocyte activating 3 [ Homo sapiens (human) ]

    Gene ID: 3902, updated on 19-Jul-2021

    Summary

    Official Symbol
    LAG3provided by HGNC
    Official Full Name
    lymphocyte activating 3provided by HGNC
    Primary source
    HGNC:HGNC:6476
    See related
    Ensembl:ENSG00000089692 MIM:153337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD223
    Summary
    Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in spleen (RPKM 15.1), lymph node (RPKM 8.3) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LAG3 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6772483..6778455)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6881686..6887621)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin Neighboring gene RNA, 7SL, cytoplasmic 380, pseudogene Neighboring gene CD4 molecule

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class II protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MHC class II protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of regulatory T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in plasmacytoid dendritic cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    lymphocyte activation gene 3 protein
    Names
    lymphocyte-activation gene 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002286.6NP_002277.4  lymphocyte activation gene 3 protein precursor

      See identical proteins and their annotated locations for NP_002277.4

      Status: REVIEWED

      Source sequence(s)
      AA687676, AC125494, AI274900, X51985
      Consensus CDS
      CCDS8561.1
      UniProtKB/Swiss-Prot
      P18627
      Related
      ENSP00000203629.2, ENST00000203629.3
      Conserved Domains (3) summary
      smart00410
      Location:267348
      IG_like; Immunoglobulin like
      pfam13895
      Location:174259
      Ig_2; Immunoglobulin domain
      cl11960
      Location:263336
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      6772483..6778455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520956.1XP_011519258.1  lymphocyte activation gene 3 protein isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:267348
      IG_like; Immunoglobulin like
      pfam13895
      Location:174259
      Ig_2; Immunoglobulin domain
      cl11960
      Location:263336
      Ig; Immunoglobulin domain
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