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    KTN1 kinectin 1 [ Homo sapiens (human) ]

    Gene ID: 3895, updated on 4-Nov-2018

    Summary

    Official Symbol
    KTN1provided by HGNC
    Official Full Name
    kinectin 1provided by HGNC
    Primary source
    HGNC:HGNC:6467
    See related
    Ensembl:ENSG00000126777 MIM:600381; Vega:OTTHUMG00000140312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CG1; KNT; MU-RMS-40.19
    Summary
    This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See KTN1 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (55580207..55684584)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (56046925..56151302)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene abl interactor 1 pseudogene 1 Neighboring gene KTN1 antisense RNA 1 Neighboring gene ribosomal protein L13a pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 520

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases activate KTN1, organism-specific biosystem (from REACTOME)
      RHO GTPases activate KTN1, organism-specific biosystemGTP-bound active forms of RHO GTPases RHOA, RHOG, RAC1 and CDC42 bind kinectin (KTN1), a protein inserted in endoplasmic reticulum membranes that interacts with the cargo-binding site of kinesin and ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0004, MGC133337

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    cadherin binding HDA PubMed 
    kinesin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane HDA PubMed 

    General protein information

    Preferred Names
    kinectin
    Names
    CG-1 antigen
    kinesin receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079521.1NP_001072989.1  kinectin isoform a

      See identical proteins and their annotated locations for NP_001072989.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (a).
      Source sequence(s)
      AL138499, AY536375, BQ014936, DA769269, Z22551
      Consensus CDS
      CCDS41957.1
      UniProtKB/Swiss-Prot
      Q86UP2
      UniProtKB/TrEMBL
      A0A024R663
      Related
      ENSP00000378725.3, OTTHUMP00000179010, ENST00000395314.7, OTTHUMT00000276912
      Conserved Domains (3) summary
      COG1196
      Location:6671352
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12128
      Location:319991
      DUF3584; Protein of unknown function (DUF3584)
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    2. NM_001079522.1NP_001072990.1  kinectin isoform b

      See identical proteins and their annotated locations for NP_001072990.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      BC117132, BQ014936, DA452468, DA769269
      Consensus CDS
      CCDS41959.1
      UniProtKB/Swiss-Prot
      Q86UP2
      Related
      ENSP00000378722.1, OTTHUMP00000179011, ENST00000395311.5, OTTHUMT00000276913
      Conserved Domains (2) summary
      TIGR02168
      Location:4581246
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:9901179
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    3. NM_001271014.1NP_001257943.1  kinectin isoform d

      See identical proteins and their annotated locations for NP_001257943.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 2. This variant encodes isoform d, which is shorter than isoform a.
      Source sequence(s)
      AK302797, BC143720, BM981127, DA769269
      UniProtKB/Swiss-Prot
      Q86UP2
      Conserved Domains (2) summary
      COG1196
      Location:3261084
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    4. NM_004986.3NP_004977.2  kinectin isoform c

      See identical proteins and their annotated locations for NP_004977.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      BM981127, DA769269, L25616
      Consensus CDS
      CCDS41958.1
      UniProtKB/Swiss-Prot
      Q86UP2
      Related
      ENSP00000391964.2, OTTHUMP00000179012, ENST00000438792.6, OTTHUMT00000276914
      Conserved Domains (1) summary
      COG1196
      Location:3261050
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. NR_073128.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses two and lacks two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY264265, BC050555, BC112337, BM981127, DA769269
    2. NR_073129.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY264265, BM981127, DA769269
      Related
      ENST00000459737.5, OTTHUMT00000276911

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      55580207..55684584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006720141.3XP_006720204.1  kinectin isoform X8

      Conserved Domains (1) summary
      TIGR02168
      Location:4801251
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. XM_024449579.1XP_024305347.1  kinectin isoform X10

      Conserved Domains (1) summary
      cl25732
      Location:4481213
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_011536752.2XP_011535054.1  kinectin isoform X2

      Conserved Domains (2) summary
      TIGR02168
      Location:4581247
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:9901179
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    4. XM_017021286.2XP_016876775.1  kinectin isoform X11

    5. XM_017021279.2XP_016876768.1  kinectin isoform X6

    6. XM_006720138.2XP_006720201.1  kinectin isoform X1

      See identical proteins and their annotated locations for XP_006720201.1

      UniProtKB/Swiss-Prot
      Q86UP2
      UniProtKB/TrEMBL
      A0A024R663
      Conserved Domains (3) summary
      COG1196
      Location:6671352
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12128
      Location:319991
      DUF3584; Protein of unknown function (DUF3584)
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    7. XM_017021280.1XP_016876769.1  kinectin isoform X6

    8. XM_011536753.2XP_011535055.1  kinectin isoform X5

      See identical proteins and their annotated locations for XP_011535055.1

      UniProtKB/Swiss-Prot
      Q86UP2
      Related
      ENSP00000394992.2, ENST00000413890.6
      Conserved Domains (2) summary
      TIGR02168
      Location:4581246
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:9901179
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    9. XM_006720139.3XP_006720202.1  kinectin isoform X3

      See identical proteins and their annotated locations for XP_006720202.1

      UniProtKB/Swiss-Prot
      Q86UP2
      Conserved Domains (2) summary
      COG1196
      Location:3261084
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    10. XM_017021284.2XP_016876773.1  kinectin isoform X9

    11. XM_006720140.4XP_006720203.1  kinectin isoform X4

      See identical proteins and their annotated locations for XP_006720203.1

      Conserved Domains (1) summary
      COG1196
      Location:4461227
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    12. XM_017021285.2XP_016876774.1  kinectin isoform X9

    13. XM_017021282.2XP_016876771.1  kinectin isoform X7

      UniProtKB/Swiss-Prot
      Q86UP2
      Conserved Domains (1) summary
      COG1196
      Location:3261050
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    14. XM_011536751.3XP_011535053.1  kinectin isoform X1

      See identical proteins and their annotated locations for XP_011535053.1

      UniProtKB/Swiss-Prot
      Q86UP2
      UniProtKB/TrEMBL
      A0A024R663
      Conserved Domains (3) summary
      COG1196
      Location:6671352
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12128
      Location:319991
      DUF3584; Protein of unknown function (DUF3584)
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    15. XM_017021283.1XP_016876772.1  kinectin isoform X7

      UniProtKB/Swiss-Prot
      Q86UP2
      Conserved Domains (1) summary
      COG1196
      Location:3261050
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    16. XM_017021278.1XP_016876767.1  kinectin isoform X1

      UniProtKB/Swiss-Prot
      Q86UP2
      UniProtKB/TrEMBL
      A0A024R663
      Conserved Domains (3) summary
      COG1196
      Location:6671352
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12128
      Location:319991
      DUF3584; Protein of unknown function (DUF3584)
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    17. XM_017021281.1XP_016876770.1  kinectin isoform X6

    RNA

    1. XR_001750312.2 RNA Sequence

    2. XR_943438.2 RNA Sequence

    3. XR_943439.2 RNA Sequence

    4. XR_001750311.2 RNA Sequence

    5. XR_001750310.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182926.2: Suppressed sequence

      Description
      NM_182926.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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