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    KTN1 kinectin 1 [ Homo sapiens (human) ]

    Gene ID: 3895, updated on 7-Apr-2024

    Summary

    Official Symbol
    KTN1provided by HGNC
    Official Full Name
    kinectin 1provided by HGNC
    Primary source
    HGNC:HGNC:6467
    See related
    Ensembl:ENSG00000126777 MIM:600381; AllianceGenome:HGNC:6467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CG1; KNT; MU-RMS-40.19
    Summary
    This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KTN1 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55580207..55684584)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49785926..49890300)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (56046925..56151302)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene abl interactor 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5786 Neighboring gene Sharpr-MPRA regulatory region 13870 Neighboring gene KTN1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:56166391-56166991 Neighboring gene uncharacterized LOC124903320 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:56219189-56219804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:56219806-56220357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:56220358-56220908 Neighboring gene ribosomal protein L13a pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0004, MGC133337

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables kinesin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    kinectin
    Names
    CG-1 antigen
    kinesin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079521.2NP_001072989.1  kinectin isoform a

      See identical proteins and their annotated locations for NP_001072989.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (a).
      Source sequence(s)
      AL138499, AY536375, BQ014936, DA769269, Z22551
      Consensus CDS
      CCDS41957.1
      UniProtKB/Swiss-Prot
      B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57
      Related
      ENSP00000378725.3, ENST00000395314.8
      Conserved Domains (3) summary
      COG1196
      Location:6671352
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12128
      Location:319991
      DUF3584; Protein of unknown function (DUF3584)
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    2. NM_001079522.2NP_001072990.1  kinectin isoform b

      See identical proteins and their annotated locations for NP_001072990.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      BC117132, BQ014936, DA452468, DA769269
      Consensus CDS
      CCDS41959.1
      UniProtKB/Swiss-Prot
      Q86UP2
      Related
      ENSP00000378722.1, ENST00000395311.5
      Conserved Domains (2) summary
      TIGR02168
      Location:4581246
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl23763
      Location:9901179
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    3. NM_001271014.2NP_001257943.1  kinectin isoform d

      See identical proteins and their annotated locations for NP_001257943.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 2. This variant encodes isoform d, which is shorter than isoform a.
      Source sequence(s)
      AK302797, BC143720, BM981127, DA769269
      UniProtKB/Swiss-Prot
      Q86UP2
      Conserved Domains (2) summary
      COG1196
      Location:3261084
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl23763
      Location:10131202
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    4. NM_001402682.1NP_001389611.1  kinectin isoform a

      Status: REVIEWED

      Source sequence(s)
      AL138499
      Consensus CDS
      CCDS41957.1
      UniProtKB/Swiss-Prot
      B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57
    5. NM_001402683.1NP_001389612.1  kinectin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL138499
    6. NM_001402684.1NP_001389613.1  kinectin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL138499
    7. NM_001402685.1NP_001389614.1  kinectin isoform d

      Status: REVIEWED

      Source sequence(s)
      AL138499
    8. NM_001402686.1NP_001389615.1  kinectin isoform d

      Status: REVIEWED

      Source sequence(s)
      AL138499
    9. NM_001402687.1NP_001389616.1  kinectin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL138499
    10. NM_001402688.1NP_001389617.1  kinectin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL138499
    11. NM_001402689.1NP_001389618.1  kinectin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL138499
    12. NM_001402690.1NP_001389619.1  kinectin isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL138499
    13. NM_001402691.1NP_001389620.1  kinectin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL138499
      Related
      ENSP00000394992.2, ENST00000413890.6
    14. NM_001402692.1NP_001389621.1  kinectin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL138499
    15. NM_001402693.1NP_001389622.1  kinectin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL138499
    16. NM_001402694.1NP_001389623.1  kinectin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL138499
      Consensus CDS
      CCDS41958.1
    17. NM_001402696.1NP_001389625.1  kinectin isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL138499
    18. NM_001402698.1NP_001389627.1  kinectin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL138499
    19. NM_001402699.1NP_001389628.1  kinectin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL138499
    20. NM_001402700.1NP_001389629.1  kinectin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL138499
    21. NM_001402701.1NP_001389630.1  kinectin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL138499
    22. NM_001402702.1NP_001389631.1  kinectin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL138499
    23. NM_001402703.1NP_001389632.1  kinectin isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL138499
    24. NM_001402704.1NP_001389633.1  kinectin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL138499
    25. NM_001402705.1NP_001389634.1  kinectin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL138499
    26. NM_001402706.1NP_001389635.1  kinectin isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL138499
    27. NM_001402707.1NP_001389636.1  kinectin isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL138499
    28. NM_001402708.1NP_001389637.1  kinectin isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL138499
    29. NM_001402709.1NP_001389638.1  kinectin isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL138499
    30. NM_001402710.1NP_001389639.1  kinectin isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL138499
    31. NM_001402711.1NP_001389640.1  kinectin isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL138499
    32. NM_004986.4NP_004977.2  kinectin isoform c

      See identical proteins and their annotated locations for NP_004977.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      BM981127, DA769269, L25616
      Consensus CDS
      CCDS41958.1
      UniProtKB/Swiss-Prot
      Q86UP2
      Related
      ENSP00000391964.2, ENST00000438792.6
      Conserved Domains (1) summary
      COG1196
      Location:3261050
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. NR_073128.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses two and lacks two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY264265, BC050555, BC112337, BM981127, DA769269
    2. NR_073129.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY264265, DA769269
      Related
      ENST00000459737.5
    3. NR_175283.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499
    4. NR_175284.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499
    5. NR_175285.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499
    6. NR_175286.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499
    7. NR_175287.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499
    8. NR_175288.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499
    9. NR_175289.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499
    10. NR_175290.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL138499

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      55580207..55684584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431361.1XP_047287317.1  kinectin isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      49785926..49890300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376038.1XP_054232013.1  kinectin isoform X1

    2. XM_054376040.1XP_054232015.1  kinectin isoform X6

    3. XM_054376031.1XP_054232006.1  kinectin isoform X2

      UniProtKB/Swiss-Prot
      B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57
    4. XM_054376030.1XP_054232005.1  kinectin isoform X2

      UniProtKB/Swiss-Prot
      B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57
    5. XM_054376034.1XP_054232009.1  kinectin isoform X3

    6. XM_054376039.1XP_054232014.1  kinectin isoform X1

    7. XM_054376029.1XP_054232004.1  kinectin isoform X2

      UniProtKB/Swiss-Prot
      B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57
    8. XM_054376032.1XP_054232007.1  kinectin isoform X3

    9. XM_054376036.1XP_054232011.1  kinectin isoform X4

    10. XM_054376033.1XP_054232008.1  kinectin isoform X3

    11. XM_054376035.1XP_054232010.1  kinectin isoform X4

    12. XM_054376037.1XP_054232012.1  kinectin isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182926.2: Suppressed sequence

      Description
      NM_182926.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.