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    GPR153 G protein-coupled receptor 153 [ Homo sapiens (human) ]

    Gene ID: 387509, updated on 17-Jun-2019

    Summary

    Official Symbol
    GPR153provided by HGNC
    Official Full Name
    G protein-coupled receptor 153provided by HGNC
    Primary source
    HGNC:HGNC:23618
    See related
    Ensembl:ENSG00000158292 MIM:614269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR1
    Summary
    This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]
    Expression
    Broad expression in colon (RPKM 6.6), fat (RPKM 4.7) and 21 other tissues See more
    Orthologs

    Genomic context

    See GPR153 in Genome Data Viewer
    Location:
    1p36.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (6247353..6261098, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6307406..6321035, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 337 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene hes family bHLH transcription factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp762B2210

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 153
    Names
    G-protein coupled receptor PGR1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053044.1 RefSeqGene

      Range
      5016..18645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_207370.4NP_997253.2  probable G-protein coupled receptor 153

      See identical proteins and their annotated locations for NP_997253.2

      Status: REVIEWED

      Source sequence(s)
      AL031847, BC068275, BQ575651
      Consensus CDS
      CCDS64.1
      UniProtKB/Swiss-Prot
      Q6NV75
      UniProtKB/TrEMBL
      A0A0I9QQ03
      Related
      ENSP00000367125.2, ENST00000377893.3
      Conserved Domains (1) summary
      pfam00001
      Location:29219
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      6247353..6261098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541434.3XP_011539736.1  probable G-protein coupled receptor 153 isoform X1

      See identical proteins and their annotated locations for XP_011539736.1

      UniProtKB/Swiss-Prot
      Q6NV75
      UniProtKB/TrEMBL
      A0A0I9QQ03
      Conserved Domains (1) summary
      pfam00001
      Location:29219
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_017001250.1XP_016856739.1  probable G-protein coupled receptor 153 isoform X1

      UniProtKB/Swiss-Prot
      Q6NV75
      UniProtKB/TrEMBL
      A0A0I9QQ03
      Conserved Domains (1) summary
      pfam00001
      Location:29219
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. XM_017001251.2XP_016856740.1  probable G-protein coupled receptor 153 isoform X2

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