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    LMP-1 latent membrane protein LMP-1 [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

    Gene ID: 3783750, updated on 13-Apr-2025
    Gene symbol
    LMP-1
    Gene description
    latent membrane protein LMP-1
    Locus tag
    HHV4_LMP-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
    Lineage
    Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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    Sequence:
    NC_007605.1 (166483..169088, complement)

    NC_007605.1Genomic Context describing neighboring genes Neighboring gene apoptosis regulator BALF1 Neighboring gene protein BARF1 Neighboring gene membrane protein LMP-2A Neighboring gene protein BNLF2b Neighboring gene protein BNLF2a Neighboring gene membrane protein LMP-2B

    Genomic Sequence:
    NC_007605.1

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Targeting the lateral interactions of transmembrane domain 5 of Epstein-Barr virus latent membrane protein 1. Wang X, et al. Biochim Biophys Acta, 2012 Sep. PMID 22609737, Free PMC Article
    2. Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L. Yang GD, et al. PLoS One, 2013. PMID 24194922, Free PMC Article
    3. High molecular weight complex analysis of Epstein-Barr virus Latent Membrane Protein 1 (LMP-1): structural insights into LMP-1's homo-oligomerization and lipid raft association. Wrobel CM, et al. Virus Res, 2013 Dec 26. PMID 24075898, Free PMC Article
    4. Epstein-barr virus latent membrane protein 1 polymorphism in nasopharyngeal carcinoma and other oral cavity tumors in Russia. Senyuta N, et al. J Med Virol, 2014 Feb. PMID 24009107
    5. NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1. Ersing I, et al. Viruses, 2013 Jun 21. PMID 23793113, Free PMC Article

    See all (266) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assembly and activation of EBV latent membrane protein 1.
      Title: Assembly and activation of EBV latent membrane protein 1.
    2. Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1.
      Title: Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1.
    3. Genetic variability and mutation of Epstein-Barr virus (EBV)-encoded LMP-1 and BHRF-1 genes in EBV-infected patients: identification of precise targets for development of personalized EBV vaccines.
      Title: Genetic variability and mutation of Epstein‒Barr virus (EBV)-encoded LMP-1 and BHRF-1 genes in EBV-infected patients: identification of precise targets for development of personalized EBV vaccines.
    4. Mutations in latent membrane protein 1 of Epstein-Barr virus are associated with increased risk of posttransplant lymphoproliferative disorder in children.
      Title: Mutations in latent membrane protein 1 of Epstein-Barr virus are associated with increased risk of posttransplant lymphoproliferative disorder in children.
    5. STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma.
      Title: STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma.
    6. Epstein-Barr virus LMP1 protein promotes proliferation and inhibits differentiation of epithelial cells via activation of YAP and TAZ.
      Title: Epstein-Barr virus LMP1 protein promotes proliferation and inhibits differentiation of epithelial cells via activation of YAP and TAZ.
    7. LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1beta upregulation.
      Title: LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1β upregulation.
    8. Latent membrane protein 1 and macrophage-derived TNFalpha synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma.
      Title: Latent membrane protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma.
    9. Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma.
      Title: Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma.
    10. Latent Membrane Protein 1 (LMP1) from Epstein-Barr Virus (EBV) Strains M81 and B95.8 Modulate miRNA Expression When Expressed in Immortalized Human Nasopharyngeal Cells.
      Title: Latent Membrane Protein 1 (LMP1) from Epstein-Barr Virus (EBV) Strains M81 and B95.8 Modulate miRNA Expression When Expressed in Immortalized Human Nasopharyngeal Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (254)
    Products Interactant Other Gene Complex Source Pubs Description

    regulatory

    • Loc: c166488-166483 regulatory_class = polyA_signal_sequence
    • Loc: c166492-166487 regulatory_class = polyA_signal_sequence
    • Loc: c167067-167062 regulatory_class = TATA_box
    • Loc: c168743-168738 regulatory_class = TATA_box
    • Loc: c169088-169083 regulatory_class = TATA_box
    Preferred Names
    latent membrane protein LMP-1

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007605.1 Reference assembly

      Range
      166483..169088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_401722.1 latent membrane protein LMP-1 [Human gammaherpesvirus 4]

      See identical proteins and their annotated locations for YP_401722.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03230, Q777A4
      UniProtKB/TrEMBL
      A0A0B6VKE3, A0A0C7TBX2
      Conserved Domains (2) summary
      PHA02644
      Location:253 → 300
      PHA02644; hypothetical protein; Provisional
      pfam05297
      Location:1 → 386
      Herpes_LMP1; Herpesvirus latent membrane protein 1 (LMP1)
    Nucleotide Protein
    Heading Accession and Version

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